Jill and Gordon's wedding day finally arrives, but a huge explosion at a nearby care home disrupts proceedings in spectacular fashion. As the Royal staff help pull the elderly residents out of the rubble, the horrifying truth behind the cause of the accident is discovered.

The hospital staff have an intriguing case on their hands when local tramp Sebastian Fox is found dead. Ken Hopkirk rummages through his belongings and is surprised to find war medals, leading to the discovery that he was a decorated Navy hero. When a relative is traced but refuses to help with funeral arrangements, the Royal team decide to give him a fitting send-off by scattering his ashes at sea. Meanwhile, Jeffrey Goodwin is shocked to discover a farmer's cattle herd have contracted a disease which has passed into cheese that's available in the area, and Jill Weatherill, Matron and Sister Brigid encounter a runaway girl.

A fishing trawler causes havoc at a wedding reception and Adam has to make a difficult choice.

A dangerous situation arises on board a sinking trawler and Matron hands in her resignation.

Samantha struggles to cope with the reality of her recent discovery and takes desperate action which leaves her life hanging in the balance. Frankie and Gordon attempt a daring rescue to help a teenager in danger on the weir, while Ken has something to hide from Harper. Jeff's casual encounter with a friend of Lizzie's suddenly turns serious when he realises his career could be at risk.

Nurse Stella Davenport arrives at the Royal with a less than favourable reputation, and soon causes a stir among the staff and patients as rumours about her circulate the hospital. Matron and Harper discover a new approach to interviewing when they try to fill a ward domestic vacancy, while Dr. Ormerod is left to deal with the dramatic aftermath of a domestic dispute, and Lizzie realises her new scooter might have been an ill-advised purchase.

Dr. Ormerod returns to work after his accident, but when his brusque treatment of a hypochondriac schoolgirl ends in tragedy, it's clear he still needs time to recover. New nurse Catherine Deane starts her rounds on the wards, and Mr. Middleditch has a surprise announcement to make.

Mr. Harper prepares for the arrival of an important private patient, who proves useful when a badly injured teenager is brought in after an industrial accident after Dr. Goodwin puts his career on the line to fight for justice for the accident victim. Sister Brigid helps a terminally ill alcoholic called Rory, and Lizzie comes to terms with her husband's recent behaviour and looks ahead to the future.

Dr. Goodwin faces the pressure as rumours about him frantically circulate the hospital and when Dr. Weatherill passes on some important news, he wastes no time in using it to set the record straight. Nurse Taylor's happiness about her future with Frankie is sensationally shattered as the extent of his dishonesty is revealed, while Matron is shocked to see a familiar face on the ward.

The hospital has its hands full when a typhoid epidemic breaks out in the community. Things get worse as the disease's source is traced back to the wards and staff struggle to locate it. Dr. Weatherill is forced to reprimand Dr. Ormerod after catching him sleeping on the job - but also has a startling piece of news to give him.

The arrival of a new locum ruffles some feathers. A day at the races seems a perfect location for Carnegie and Catherine to enjoy they first date - but only if they can keep out of everyone's way.

A patient who set fire to his own shop attempts to avoid police questioning by leaping into an ambulance and driving off towards the pier - unaware that Alun and a sick man are in the back of the vehicle.

As the hospital staff come to terms with the loss of Stella and Frankie, everyone’s surprised when an attractive surfer, who crashes into Dr Burnett’s car, turns out to be the new ambulance driver, Bobby. Alun is getting ready for a gig in town with his new band and deafens everyone while he practices in the porter’s office. Marian reasons that they should all go and watch the gig as Stella loved a good night out and wouldn’t want to see her friends sitting in every night. However, when Dr Burnett explains he can’t go as he’s on call, Marian is soon charmed by Bobby, who agrees to be her date to the gig. Will Marian turn to Bobby for a good time?

Dr. Cheriton has the unenviable task of informing a patient she has little time to live, and the situation soon prompts the wedding of the year. Arriving at the scene of an accident at the railway station, Dr. Ormerod is forced to make a drastic decision, but an oncoming train signals disaster. Gambling fever grips the hospital when a champion jockey is admitted and, as always, Greengrass is in the thick of the furore.

Matron is forced to change her plans after a tragic turn of events and decides to withdraw her resignation. Nurse Taylor grows closer to Jeff as they tackle an unusual medical emergency, but later finds herself confronted by an angry Frankie. Harper's money-saving schemes backfire in spectacular fashion, while an argument over a patient's health sparks off a chain of events which leaves Gordon's life hanging in the balance.

An accident at the harbor leaves a fisherman concerned for the future of his family when Burnett is forced to amputate his hand. Weatherill treats a woman admitted with pneumonia who is deeply concerned about her father's presence around her daughter. Ken bids a final farewell to The Royal, but Lizzie's resolve flounders at the last minute.

Dr Burnett is called out to a run down farm house where 15-year-old Simon, who has speech and learning difficulties, is running a high fever. The farm is in a bad state and the family seem to be struggling to cope. They’re horrified when Burnett reveals he needs to get Simon to hospital ASAP in order to rule out meningitis. Will they get to the bottom of Simon’s illness?

Dr. David Cheriton arrives at St. Aidan's Royal Free Hospital in Elsinby, newly qualified and keen to impress at his job interview - only to discover they aren't even expecting him. Meanwhile, Dr. Jill Weatherill's professional competence is called into question during a home visit, and hospital porter Ken Hopkirk's efforts to put up a television aerial end in disaster.

The cause of a schoolboy's illness is found too close to home, while a bit of teamwork brings Ormerod and Weatherill closer than they expect. Cheriton's flatwarming party goes with a bang, and Ventress spots an impostor on the ward.

Matron is injured by a thief and Jeff fears he is gaining a bad reputation. Meanwhile, an outbreak of tubercolosis keeps the staff busy.

Dr. Ormerod and Dr. Weatherill accompany Brigid back to Ireland for Moira's funeral, and uncover shocking family secrets in the process. Meanwhile, a new locum is thrown in at the deep end at the Royal.

A romantic escapade goes horribly wrong when a young couple are involved in a motorbike accident, and the tragic events of the night leave the staff of St Aiden's struggling to heal more than just a broken heart. Dr. Ormerod grows suspicious when one of his patients is uneasy about returning home, but an investigation by Matron soon reveals the reasons for his reluctance. Meanwhile, Ken and Alun face trouble when a plague of rodents looks set to close down the hospital - but is local rogue Claude Greengrass really the best person to ask for advice?

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Frankie faces trouble when someone tries to steal his motorbike

Dr Makri takes a crash course in dealing with Yorkshire folk. Stella deals with the confessions of a window cleaner.