In the first of a new series, Professor Noel Fitzpatrick and his team treat a giant Newfoundland puppy with a painful knee and shoulder. What appears straightforward quickly turns into a much bigger concern, and Noel and his team are challenged to invent not one but two new implants for her. Meanwhile, a rescue black Labrador called Moogi is in need of treatment for severe elbow arthritis, and a golden Labrador born with a deformed front paw is offered a bionic solution in the form of a unique, custom-made prosthesis.

Noel Fitzpatrick treats a Persian cat that has been hit by a car, requiring treatments involving a skin graft and putting its crushed bones back together. Meanwhile, a rescue dog has a cancerous tumour in his jaw removed, and a young staffie-cross needs treatment for a developmental elbow disease.

A 10-month-old puppy called Albie is knocked over by a car on a family camping holiday is rushed in as an emergency admission, and Noel Fitzpatrick fears this may be a life or death situation. Elsewhere, a Scottish terrier has a mysterious ailment, and a 16-month-old spaniel, is suffering from severe arthritis affecting both hips.

Noel Fitzpatrick faces one of his greatest practical and ethical challenges yet when he's introduced to Hermes, a tortoise with only one good leg. Can he provide Hermes with three prosthetic feet, using tiny titanium implants? Meanwhile, a rottweiler called Dave urgently needs an upgrade to his previous hip replacements.

A small cavachon is rushed to see Professor Noel Fitzpatrick after being hit by a car. She has a broken leg, but also a serious heart condition. Meanwhile, Simba, a one-year-old Labrador needs help with her badly formed hips, and Tulee the nervous basset hound has diseased discs in her back that leave her in constant pain.

Noel Fitzpatrick offers cutting-edge treatment for Luca, a long-suffering four-year-old springer spaniel with a painful elbow disease. He designs and creates a special screw for Luca's leg with a system for injecting a bone-growth gel around it, and after an eight-year-old Newfoundland collapses, its owners face an agonising wait for the MRI scans to reveal if anything can be done for the gentle giant.

Rescue Labrador Tom needs work with a serious wound on one of his front paws, and four-year-old French bulldog called Otis has suffered an accident while being chased by another dog. Professor Noel Fitzpatrick diagnoses a spinal problem high up in Otis's neck that requires surgery. Meanwhile, Bailey, a 10-year-old cocker spaniel, has quite a lot of pain in one of his hind limbs, but his owner wants to avoid surgery, and Noel needs to perform specialist imaging before he can offer any solutions.