Professor Noel Fitzpatrick performs a risky procedure to save the life of an 18-week-old cockapoo puppy that has fractured its neck following an accident in the garden. He also comes to the aid of Romanian stray Geoffrey, who was found abandoned and emaciated before being adopted by Kent couple John and Stacey, and an accident-prone cat called MK who has fallen from a window.

A five-year-old Great Dane is rushed to Fitzpatrick Referrals after losing the use of its back legs due to a slipped disc, with complications leaving the dog fighting for its life. A woman and her two children bring their pet spaniel to the practice after it is hit by a car, and a 10-year-old collie with hip dysplasia visits the surgery.

Professor Noel Fitzpatrick tends to a Newfoundland called Billy, who clocks up thousands of miles travelling back and forth from his home in Aberdeen for treatment on its legs. He also attempts to help Barney, a Yorkshire terrier that has a deformity in its neck that is compressing its spinal cord. For owners Linda and Barry, Noel is their last chance, but the operation involves high-risk surgery with no guarantee of success.