Joey Diaz shares his definition of true friendship, and Ari Shaffir and Pete Carboni remember getting separated while tripping on mushrooms for the first time.

Marc Maron's hypochondria leads him to a neurologist, Ms. Pat discovers the importance of having big breasts, and Steve Rannazzisi's mission for a late-night snack goes awry.

Tom Papa looks back on methods of teenage seduction, Ralphie May gets high at a same-sex wedding, and Rob Corddry's wife accidentally sends a horrible email.

Iliza Shlesinger remembers a duplicitous boyfriend, Barry Rothbart recalls an eventful trip to Atlantic City, and Big Jay Oakerson describes a risque game of truth or dare.

Keegan-Michael Key remembers driving around Detroit with a crackhead, Bobby Lee chats about his time on "MADtv," and Ari Shaffir describes smuggling pot gummy bears.

Paul Scheer admonishes an irresponsible pet owner, Ali Siddiq learns the meaning of important prison slang, and Bert Kreischer wrestles a bear for his television show.

Cristela Alonzo describes a romantic trip that went awry, Tom Segura remembers meeting fellow comic Bruce Bruce, and Joe Rogan looks back on an unexpected hotel evacuation.

DL Hughley describes how growing up in Los Angeles shaped his worldview, Jay Larson reveals how he won a morning radio contest, and Ari Shaffir remembers a childhood grudge.