Years after the Civil War, Major Adams gets a second chance with his lost love Ranie, who had married in his absence. But happiness doesn't always come easy, as a sinister rival and a dark secret attest.

During a storm, Flint takes shelter at a farmhouse. He soon discovers the husband is refusing his wife the care of a midwife and before it's too late for her he needs to find out why.

During the Civil War Charlie Wooster joins Bill Hawks under the command of Major Seth Adams. When Adams is seriously wounded saving Hawks's life he must struggle to survive, while dreaming of the girl he left behind.

Ruttledge Munroe joins the wagon train on the trail. It's noticed right off his odd sense of humor but when he saves the major's life, it is forgotten until he kills someone else and the real reason he joined up is revealed.

Mary Halstead is in search of a son she gave up a long time ago. With months to live, she comes west on the trail of someone who could be her son, but he may also turn out to be a notorious outlaw.

Faith is tested when a man's wife is injured and he refuses medical aid. When Flint rides to the nearest town to get a doctor, he finds they have their own problems: a smallpox epidemic.

Tensions are running high in the train between northerners and southerners traveling west. As trouble escalates one passenger with a noticeable limp, John Wilbot, is accused of being John Wilkes Booth, who many believe is still alive.

Willy Moran, a drunk, is hired by a wagon as a driver. He is an army buddy of the Major, but is used as a fall guy by a member of the train who wants to rob it. When the battle starts, Willy uses his army skills to turn the battle.

The train cannot get supplies after a member kills the son of the man who owns most of St. Joseph in self-defense. He escapes with the help of Flint but when he learns the train is still being denied supplies he returns to face hanging.

Revolutionary Bernal Sierra joins the train finding the wife of his dead friend married to Casey Reardon who sold guns to the Mexican revolutionaries. Bernal is suspicious of Casey, his brothers, and Perdita over missing gold.

Low on water, Flint scouts for more. When three water holes are dry or poisoned, Fort Paiute seems their only hope but he has to make it back to the wagon train on foot and the only other man who knows the way is believed to be a deserter.

Ruth Owens remarries and is moving west with her new husband. When her brother comes looking for her, he stirs up trouble for her about her past and himself because he just killed a man.

Les Rand, just released from prison for murder, goes back home to kill the man he held responsible; his father, the doctor. Meanwhile, Flint is there to fetch the doctor to help someone injured. Les vows that no one will stand in his way.

Emily Rossiter had a young daughter to care for. She met and married someone she felt she could trust. When she found out this was misplaced, getting the daughter away from him and into a better life becomes her main goal.

Lieutenant Avery has a mission. Deliver a peace treaty and the chief's daughter. But he has a secret vendetta that may jeopardize everyone's hope for peace.

Bill Tawnee served his country heroically. When Major Adams recognizes him on the trail and sees he is unable to wake, he asks his wife to join his wagon train even though there is plenty of anti-Indian sentiment afloat.

In a growing town, Seth meets a friend from his distant past. He remembers how they met and the circumstances bringing them west. When his friend's home is threatened, not ever wearing a gun surprisingly helps him rather than the reverse.

On one final push to the west, a wild west showman runs into some old friends. Some that were part of a massacre that almost cost them their lives and one man his sanity.

At the end of a long journey, lives were lost. Some made it with their dreams intact. Flint tries to help two of the passengers with theirs and almost bites off too much. Politics are involved as well as unsolicited trips to the Far East.

When the train picks up an abandoned drunk on the trail, he exposes John Darro to be the reviled coward John Thurman who abandoned a previous train during a massacre. Darro's young son Tommy is unable to cope with the truth.

Horse, a name he comes to be called, is searching for himself. Since he doesn't feel that he found it in Boston, where he grew up, he tries out west, under the watchful eye of a small tribe of Crow.

The MacGregor clan decides to come to America and start a new life. The wagon trains going to California have had a hard time dealing with their different customs. Can Major Adams' be any different?

Trail hardened Cassie Tanner joins the train, and sets her eye on Major Adams. But the train desperately needs horses, and she may be the only one who can make the dangerous journey to buy them.

A pacifist since the war, Nels Stack stands up to any man prejudiced against another. When his own beliefs are tested in the face of an impending Indian attack against the wagon train, he has to decide who he is going to defend.

Riley Gratton has always drifted from here to there, a smooth tongue getting him whatever he needed. When he tries to do the same with some folks on the Major's wagon train, what comes next may be the least of his worries.