While preparing to return to St. Joseph, the men read the story "Wagon Ho" written and printed by Samuel T. Evans about his trip as a naive young Irishman headed west and his experiences and adventure on the trail.

Adams' "distant" cousin Horace arrives hoping to be a wagon master. His trading skills allow him to steal the crew and vendors from Adams but when Adams confronts him with the decisions he must make on the trail, there are second thoughts.

Arrogant British Colonel Albert Farnsworth causes an uproar in camp and puts the wagon train in danger of Indian attack, resulting in the capture of a young girl by the Cheyenne and the mortal wounding of his long time aide.

When someone yells horse thief, Flint shoots a man only to find he is the husband of a childhood friend. Flint learns the man is mayor and highly respected. The question of whether he killed an innocent man bothers him and the man's son.

Bill Hawkes is leading 3 wagons through Indian territory. They run into trouble with Mexician bandits lead by Lee Marvin. When the 2 groups must band together to fight off an Indian attack, certain biases & assumptions are thrown away.

Ordered by Major Adams to guide three passengers to a campsite up a haunted mountain, Flint does so but with caution: rumours that an escaped group of Aztecs now live there, almost 400 years after Cortez wiped them all out.

One murder begets a second murder while a treacherous journey awaits the wagon train. An unknown scout and Kiowa Indians threaten the pass. Now there may be a renegade and murderer in their midst which Adams must resolve before continuing.

Heed the signs! Or so says Samuel Bleymier. When the rains won't stop a splintered group of the wagon train has to travel through a Sioux Indian burial ground. That may have consequences all its own but what of the signs?

Dr. Craven feels he can't perform surgery any longer. When he joins the wagon train and his services are desperately needed, he realizes he may be wrong after Major Adams gives him a history lesson.

Flint discovers a badly wounded waitress on the range and takes her to a doctor, where he finds the evil town's owner wants to hang her without trial, because he suspects she murdered his son.

Gabe Henry and his son have been sorely missing the female touch over five years now. Finding a wife during a stopover is his top priority but his choice is known to Major Adams and he does not approve.

A green Army Colonel wipes out a village of Comanche women and children thinking he is getting revenge. The wagon train must face on the one side a swollen river they must cross or a Comanche chief on the other who seeks justice.

Roger Bigelow turns to the ministry with his father's help when he realizes what he might become without it. He gets the chance to help someone else on the wrong path but Major Adams is not sure the reverend is helping the right person.

When the wagon train passes through town, habitually drunk Jeremy Dow finds that his past has caught up with him. His choices: continue running, or face the demons from his past when he is confronted with this wife and son on the train.

Wounded Bill Strode arrives in camp looking for Flint. Strode, who saved Flint's life in Abilene, asks Flint to help him get to Fort Kearny. Flint learns the itchy Strode is being hunted by bounty hunter Earl Packer and Strode has changed.

A Quaker schoolteacher heads to the Arapaho nation on the wagon train when her husband is killed. She meets the Chief and his willingness to fight another Indian nation puts her right in the middle of each tribe's pride and customs.

A retired Captain and ten boys join the wagon train on their way to California. Hitching a ride was all he thought he was involving the boys in until he meets one man on the train with a secret resentment.

Bill and Major Adams plan on going hunting with a friend but when he is not home they suspect a renegade party of Cheyenne who have broken the peace treaty and the wagon train may be their next target.

The story of the women of the wagon train and the unforgiving prairie through which they pass. Who will endure, and who will give up? Who will live, and who will die?

At a Rocky Mountains fort , a wounded soldier asks his old friend Ruddy Blaine to bring his daughter to him before he dies. With the Ute Indians on the warpath, Blaine will have to take a dangerous route known only to him and the Shoshone.

Looking forward to some time off, Flint heads towards the town of Monument but runs into an old man and some kids whose parents were just massacred by some Mescaleros and they're running low on supplies especially milk for the baby.

The leaders of the wagon train are taken aback when they see a woman asking to join the wagon train who is the twin of Major Adams one and only love who died in his arms.

When Flint brings a stranded woman and boy to the train, her husband who went off to find help is also found but his return to the train sets off tempers when four men recognize him and their only thought is murder.

A married couple use the wife's innocent face and winning way with children to gain the trust of their companions on the wagon train so that they won't be suspected when the husband pulls off a bank robbery nearby.

Flint meets Chris Hale alone on the prairie. Hale has just found his entire family massacred by Indians, and Flint asks him to join the wagon train. However, the company that owns the wagon train has hired a new wagonmaster, Jud Benedict. Benedict is a ruthless and brutal tyrant who puts time above all other considerations, and does not care how many people are left behind or even die in the process of heading to the final destination as soon as possible. He has also hired unscrupulous gunmen to enforce this goal by brutalizing slower people, or anyone who stands up to him. It is revealed that Hale has also been a wagonmaster, but has retired from the job and does not ever want such a responsibility again. Still, people on the train are looking to Hale to stand up to Benedict.