Nancy is having one of the worst and busiest days of life. One of sons is missing. Shane's graduation and the deal with U-Turn make her feel like she needs to be in two places at once even though she really doesn't feel like being in either of them. Heylia's plan is put into action. Nancy tries to deal with Conrad's kiss, Celia's madness, and Kat's craziness. Everything comes to a head when the deal goes wrong.

In the season 6 finale, Nancy must free herself from the grip of Esteban in order to escape the country along with her family. At the airport, Andy attempts to calm the nerves of Shane and Warren. Meanwhile, Silas must decide whether to stay with Lars or leave with the Botwins.

The DEA brings Nancy in for questioning and then she must explain things to Esteban. Celia travels deep into Mexico to make amends with estranged daughter Quinn. Meanwhile, Silas meets Lisa's ex-husband and Doug finds a reason to live. Nancy makes a shocking revelation to Esteban.

Isabelle experiments, Andy gets drafted, Peter may not be who Nancy thinks he is, Silas gets high, and Nancy cuts out the middleman.

Peter isn't happy about the nickname "Agent Wonderbread" and he lets Nancy and Conrad know so with a convinving threat. Nancy looks to other people in the business for help. Kat's got a secret and Shane's girlfriend doesn't like her. Heylia has a plan.

As the wildfire approaches, everyone must evacuate. Nancy tells her family to pack up, while Conrad and Heylia must say goodbye to the growhouse. The authorities question Sullivan and Celia, while Shane continues to ask Nancy about Pittsburgh. As Andy deals at the evacuation center, Silas realizes the truth about Tara.

Guillermo gives Nancy a new job and she soon finds working retail isn't as mundane as it appears on the surface. Celia's deal with Captain Till brings her dangerously close to the action. Meanwhile, having been left in the desert by Nancy, Andy finds himself with a pack of immigrants and a very unfriendly Coyote. Back at home, the boys battle an infestation of bees.

Nancy learns of Esteban's fate and takes action to preserve her own. Andy makes a big change in his life. Dean, Doug and Celia find common ground. Silas helps Adelita with a disturbing medical issue.

Isabelle is auditioning for the Huskeroo ads afterall. Once Celia sees that Isabelle has an opportunity to go national she may change her mind about Isabelle's involvement. Celia is still campaigning and is starting to wonder what Nancy does during all of her "free time" as a widowed housewife. Conrad lays out the details of the operations of their Armenian neighbors and Nancy comes up with a plan. Silas may have more to deal with than a baby on the way. Shane finally starts to fit in at school. Heylia prepares for her first date with Joseph.

After being threatened by U-Turn and The Armenians, Nancy goes in search of Silas and her hijacked pot. Meanwhile, Celia has Silas arrested for stealing her "Drug Free Zone" signs. Nancy visits him in jail only to discover that the pot is still in his car - the one that Celia has just driven away in.

After Bubbie's death, the entire Botwin family sits shiva (the Jewish period of mourning) for seven days. After shiva, Nancy is sent on a mission and takes Andy along with her. Now that shiva is over and Bubbie is gone, Lenny decides to sell the house. Meanwhile, Celia continues her flirtation with Captain Till, and Doug finds refuge with the Botwins.

Despite their busy schedules, Nancy and Esteban try to find some time for each other. After finding out about Shane's fantasies and Silas's new and much older girlfriend, Nancy also has to talk to both of her sons. With their relationship going on, Lisa and Silas add some special offerings to her cheese shop.

While Nancy is trying to figure out what do with Peter, she comes home to problems of plumbing that are related to Shane and his arrival into puberty. Celia enrolls Isabelle in boot camp and ends up getting sucked into it herself. Heylia is interested in a Nation of Islam member and his bean pies.

Conrad and Nancy take their product to be tested in the market. They run into some upscale clients on the way. Celia tries to get Dean to help her with a speech that she must give in front of some kids as the new City Councilwoman. Celia wants to close a dog park. Nancy goes to invest some of her cash in jewelry. Heylia finds out that Nancy and Conrad are working together on their own seperate venture and she lets them know that she knows.

With U-Turn's timely demise Nancy and Conrad check the status on their debts and then they check in with each other. Someone is pregnant and they are keeping it. Doug continues to try to sabotage Celia and Celia continues to sabotage Nancy. Nancy celebrates something. Silas begins spending more time with Tara.

When Nancy is denied a share of the incoming pot by Guillermo, she decides to go over his head to Esteban. Celia discovers the cheap medication at Mexican pharmacies. Silas and Lisa get intimate, while Shane discovers some shocking photos. Andy and Doug begin interviewing for their human smuggling operation.

A spontaneous date ends in near-violence for Nancy and Esteban; Silas reveals to Lisa that he grows pot, and she makes him a tempting offer; Andy and Doug smuggle their first customer across the border; Celia develops an addiction.

Nancy must deal with the aftermath of Shane's exploits, her Ayahuasca trip, and more confrontation with Guillermo. Celia's struggles with her rehab partner, Barry, force her to find a new rehab facility. Doug and Maria's relationship quickly goes south and they both turn to Andy for help. Meanwhile, Silas's "sandwich" business has grown too big, forcing him to turn to Nancy for help.

Faced with the aftermath of Shane having murdered Pilar, Nancy grabs Shane and Silas and they flee the scene. Andy is then met with the decision to split town with his family or stay and fight for Audra's affection.

After hours of aimless driving, Nancy, ignoring Shane's suggestion of hiding out in Pittsburgh, hatches a plan for the family to cross into Canada. Andy is tasked with acquiring fake IDs. Silas must decide if he's willing to live on the lam. Elsewhere, Esteban must answer to authorities regarding Pilar's murder and Nancy's whereabouts.

Nancy brings her son back while Andy and Silas wait in a diner.

Nancy does her best to cope with the loss of Conrad's help, who runs into some trouble while venturing out on his own. Andy is still trying to get into rabbinical school by writing an essay on what being Jewish means to him. And Silas deals with Megan's acceptance to Princeton in his own unique way.

Nancy takes on an alias to help Conrad set up the grow house. Isabelle get approached to be a model. Interesting things happen to Celia while she's on the campaign trail. Shane makes an attempt to fit in at his school. Andy takes Shane to a massage parlor. Shane gets a surprise and Silas has one as well.

Nancy has another full week of trouble to deal with and Doug isn't helping. Heylia teaches Celia.

After settling her family in Ren Mar, Nancy turns her attention back to business. Later, Guillermo gives her a much-needed crash course in "running" across the border. Meanwhile, Celia gets further acquainted with life in prison. Lenny leaves Silas and Shane to care for Bubbie while he goes to the track. When Lenny returns, Andy confronts him about some family history.