Nancy is having one of the worst and busiest days of life. One of sons is missing. Shane's graduation and the deal with U-Turn make her feel like she needs to be in two places at once even though she really doesn't feel like being in either of them. Heylia's plan is put into action. Nancy tries to deal with Conrad's kiss, Celia's madness, and Kat's craziness. Everything comes to a head when the deal goes wrong.

In the season 6 finale, Nancy must free herself from the grip of Esteban in order to escape the country along with her family. At the airport, Andy attempts to calm the nerves of Shane and Warren. Meanwhile, Silas must decide whether to stay with Lars or leave with the Botwins.

Nancy and Andy try to put the brakes on Zoya's attempt to take over the bike shop; Silas has an encounter with some local rival dealers; and Doug must do some business with the Securities and Exchange Commission.

The DEA brings Nancy in for questioning and then she must explain things to Esteban. Celia travels deep into Mexico to make amends with estranged daughter Quinn. Meanwhile, Silas meets Lisa's ex-husband and Doug finds a reason to live. Nancy makes a shocking revelation to Esteban.

Nancy learns of Esteban's fate and takes action to preserve her own. Andy makes a big change in his life. Dean, Doug and Celia find common ground. Silas helps Adelita with a disturbing medical issue.

Nancy is rushed to the hospital after being shot as the family follows close behind. The family grapples with the tragedy and hypothesizes on the shooter's identity.

Peter isn't happy about the nickname "Agent Wonderbread" and he lets Nancy and Conrad know so with a convinving threat. Nancy looks to other people in the business for help. Kat's got a secret and Shane's girlfriend doesn't like her. Heylia has a plan.

Andy attempts to impress Jill by coaching the twin's roller-derby team; Doug ponders about his financial future after being forced to resign from the company; Nancy and Silas race to thwart Shane's actions, who is closing in on Tim.

Isabelle experiments, Andy gets drafted, Peter may not be who Nancy thinks he is, Silas gets high, and Nancy cuts out the middleman.

While Nancy is trying to figure out what do with Peter, she comes home to problems of plumbing that are related to Shane and his arrival into puberty. Celia enrolls Isabelle in boot camp and ends up getting sucked into it herself. Heylia is interested in a Nation of Islam member and his bean pies.

Isabelle is auditioning for the Huskeroo ads afterall. Once Celia sees that Isabelle has an opportunity to go national she may change her mind about Isabelle's involvement. Celia is still campaigning and is starting to wonder what Nancy does during all of her "free time" as a widowed housewife. Conrad lays out the details of the operations of their Armenian neighbors and Nancy comes up with a plan. Silas may have more to deal with than a baby on the way. Shane finally starts to fit in at school. Heylia prepares for her first date with Joseph.

Conrad and Nancy take their product to be tested in the market. They run into some upscale clients on the way. Celia tries to get Dean to help her with a speech that she must give in front of some kids as the new City Councilwoman. Celia wants to close a dog park. Nancy goes to invest some of her cash in jewelry. Heylia finds out that Nancy and Conrad are working together on their own seperate venture and she lets them know that she knows.

As the wildfire approaches, everyone must evacuate. Nancy tells her family to pack up, while Conrad and Heylia must say goodbye to the growhouse. The authorities question Sullivan and Celia, while Shane continues to ask Nancy about Pittsburgh. As Andy deals at the evacuation center, Silas realizes the truth about Tara.

Nancy confronts an old friend, leaving Silas caught in the crossfire; back at the loft, Andy comes up with a new business venture, and turns to Shane and Doug for help.

After being threatened by U-Turn and The Armenians, Nancy goes in search of Silas and her hijacked pot. Meanwhile, Celia has Silas arrested for stealing her "Drug Free Zone" signs. Nancy visits him in jail only to discover that the pot is still in his car - the one that Celia has just driven away in.

Sanjay has a new experience. Nancy gets bruised. Conrad won't do what U-Turn wants him to. Lupita still won't follow orders. Heylia's out to handle a few things. The Amber Alert is still out on Shane. Andy gets in trouble with a couple who make him for a child molester. Silas gets to talk to Shane. Celia is still having problems with her husband and daughter. Doug begs Celia to forgive him.

Nancy discovers who betrayed her and finds out she's being trailed. Some people lose their jobs. Silas discovers something about Tara. Shane installs a security system.

Guillermo gives Nancy a new job and she soon finds working retail isn't as mundane as it appears on the surface. Celia's deal with Captain Till brings her dangerously close to the action. Meanwhile, having been left in the desert by Nancy, Andy finds himself with a pack of immigrants and a very unfriendly Coyote. Back at home, the boys battle an infestation of bees.

After showing Esteban the proof of her baby, a sonogram picture. Nancy returns to Ren Mar to her family, but still unsure of her fate. Meanwhile, Celia is held hostage in Mexico by her estranged daughter Quinn who tries to ransom her off to all her friends, but they hilariously decline to deliver the cash for her release. Back in Ren Mar, Andy, Silas and Doug discuss plans to grow pot in a national forest.

Faced with the aftermath of Shane having murdered Pilar, Nancy grabs Shane and Silas and they flee the scene. Andy is then met with the decision to split town with his family or stay and fight for Audra's affection.

After hours of aimless driving, Nancy, ignoring Shane's suggestion of hiding out in Pittsburgh, hatches a plan for the family to cross into Canada. Andy is tasked with acquiring fake IDs. Silas must decide if he's willing to live on the lam. Elsewhere, Esteban must answer to authorities regarding Pilar's murder and Nancy's whereabouts.

Nancy becomes a scab labor in a Seattle hotel while Shane looks after Stevie and Doug goes back to Ren Mar

Nancy brings her son back while Andy and Silas wait in a diner.

Three years after Nancy's selfless act to save her family, Andy, Silas, Shane and Doug live their new lives in Copenhagen. When Nancy is released early from prison and put on parole to a New York halfway house, she finds out that she doesn't need witness protection anymore.

Nancy, Andy and Silas strike back at Emma; Doug has to keep his hedge fund up and running; Shane ends up closer to the law.