Nancy is having one of the worst and busiest days of life. One of sons is missing. Shane's graduation and the deal with U-Turn make her feel like she needs to be in two places at once even though she really doesn't feel like being in either of them. Heylia's plan is put into action. Nancy tries to deal with Conrad's kiss, Celia's madness, and Kat's craziness. Everything comes to a head when the deal goes wrong.

In the season 6 finale, Nancy must free herself from the grip of Esteban in order to escape the country along with her family. At the airport, Andy attempts to calm the nerves of Shane and Warren. Meanwhile, Silas must decide whether to stay with Lars or leave with the Botwins.

The DEA brings Nancy in for questioning and then she must explain things to Esteban. Celia travels deep into Mexico to make amends with estranged daughter Quinn. Meanwhile, Silas meets Lisa's ex-husband and Doug finds a reason to live. Nancy makes a shocking revelation to Esteban.

Isabelle experiments, Andy gets drafted, Peter may not be who Nancy thinks he is, Silas gets high, and Nancy cuts out the middleman.

Nancy learns of Esteban's fate and takes action to preserve her own. Andy makes a big change in his life. Dean, Doug and Celia find common ground. Silas helps Adelita with a disturbing medical issue.

Peter isn't happy about the nickname "Agent Wonderbread" and he lets Nancy and Conrad know so with a convinving threat. Nancy looks to other people in the business for help. Kat's got a secret and Shane's girlfriend doesn't like her. Heylia has a plan.

After Bubbie's death, the entire Botwin family sits shiva (the Jewish period of mourning) for seven days. After shiva, Nancy is sent on a mission and takes Andy along with her. Now that shiva is over and Bubbie is gone, Lenny decides to sell the house. Meanwhile, Celia continues her flirtation with Captain Till, and Doug finds refuge with the Botwins.

Guillermo gives Nancy a new job and she soon finds working retail isn't as mundane as it appears on the surface. Celia's deal with Captain Till brings her dangerously close to the action. Meanwhile, having been left in the desert by Nancy, Andy finds himself with a pack of immigrants and a very unfriendly Coyote. Back at home, the boys battle an infestation of bees.

Despite their busy schedules, Nancy and Esteban try to find some time for each other. After finding out about Shane's fantasies and Silas's new and much older girlfriend, Nancy also has to talk to both of her sons. With their relationship going on, Lisa and Silas add some special offerings to her cheese shop.

While Nancy is trying to figure out what do with Peter, she comes home to problems of plumbing that are related to Shane and his arrival into puberty. Celia enrolls Isabelle in boot camp and ends up getting sucked into it herself. Heylia is interested in a Nation of Islam member and his bean pies.

Isabelle is auditioning for the Huskeroo ads afterall. Once Celia sees that Isabelle has an opportunity to go national she may change her mind about Isabelle's involvement. Celia is still campaigning and is starting to wonder what Nancy does during all of her "free time" as a widowed housewife. Conrad lays out the details of the operations of their Armenian neighbors and Nancy comes up with a plan. Silas may have more to deal with than a baby on the way. Shane finally starts to fit in at school. Heylia prepares for her first date with Joseph.

Conrad and Nancy take their product to be tested in the market. They run into some upscale clients on the way. Celia tries to get Dean to help her with a speech that she must give in front of some kids as the new City Councilwoman. Celia wants to close a dog park. Nancy goes to invest some of her cash in jewelry. Heylia finds out that Nancy and Conrad are working together on their own seperate venture and she lets them know that she knows.

As the wildfire approaches, everyone must evacuate. Nancy tells her family to pack up, while Conrad and Heylia must say goodbye to the growhouse. The authorities question Sullivan and Celia, while Shane continues to ask Nancy about Pittsburgh. As Andy deals at the evacuation center, Silas realizes the truth about Tara.

When Nancy is denied a share of the incoming pot by Guillermo, she decides to go over his head to Esteban. Celia discovers the cheap medication at Mexican pharmacies. Silas and Lisa get intimate, while Shane discovers some shocking photos. Andy and Doug begin interviewing for their human smuggling operation.

A spontaneous date ends in near-violence for Nancy and Esteban; Silas reveals to Lisa that he grows pot, and she makes him a tempting offer; Andy and Doug smuggle their first customer across the border; Celia develops an addiction.

Nancy must deal with the aftermath of Shane's exploits, her Ayahuasca trip, and more confrontation with Guillermo. Celia's struggles with her rehab partner, Barry, force her to find a new rehab facility. Doug and Maria's relationship quickly goes south and they both turn to Andy for help. Meanwhile, Silas's "sandwich" business has grown too big, forcing him to turn to Nancy for help.

After being threatened by U-Turn and The Armenians, Nancy goes in search of Silas and her hijacked pot. Meanwhile, Celia has Silas arrested for stealing her "Drug Free Zone" signs. Nancy visits him in jail only to discover that the pot is still in his car - the one that Celia has just driven away in.

Sanjay has a new experience. Nancy gets bruised. Conrad won't do what U-Turn wants him to. Lupita still won't follow orders. Heylia's out to handle a few things. The Amber Alert is still out on Shane. Andy gets in trouble with a couple who make him for a child molester. Silas gets to talk to Shane. Celia is still having problems with her husband and daughter. Doug begs Celia to forgive him.

Nancy discovers who betrayed her and finds out she's being trailed. Some people lose their jobs. Silas discovers something about Tara. Shane installs a security system.

After settling her family in Ren Mar, Nancy turns her attention back to business. Later, Guillermo gives her a much-needed crash course in "running" across the border. Meanwhile, Celia gets further acquainted with life in prison. Lenny leaves Silas and Shane to care for Bubbie while he goes to the track. When Lenny returns, Andy confronts him about some family history.

Nancy makes her first successful smuggling run across the border with both drugs and human cargo. Meanwhile, Captain Till strikes a deal with Celia to get her out of jail. In return, she must gather evidence to incriminate Nancy and Guillermo. Back in Ren Mar, Andy tries to convince the family, including his father, to put Bubbie out of her misery.

Nancy follows the tunnel in the back of the maternity shop and sees something she shouldn't at the other end. Dean takes a new job, leaving Isabelle to live with Celia. Meanwhile, Silas flirts with Lisa, and Doug falls in love with a vision of beauty who washes up on the beach.

Nancy learns that the tunnel is being used for more than drugs. Esteban puts her fears to rest as well as her nagging headache with a strong remedy. Celia's family stages an intervention in order to force her into rehab. Andy finds Maria and takes her across the border to an awaiting Doug. Silas babysits while Shane explores new territory with his two girlfriends.

After showing Esteban the proof of her baby, a sonogram picture. Nancy returns to Ren Mar to her family, but still unsure of her fate. Meanwhile, Celia is held hostage in Mexico by her estranged daughter Quinn who tries to ransom her off to all her friends, but they hilariously decline to deliver the cash for her release. Back in Ren Mar, Andy, Silas and Doug discuss plans to grow pot in a national forest.

The Botwins' flight continues after a parking violation and Doug gets into a hostage situation.