In the season 6 finale, Nancy must free herself from the grip of Esteban in order to escape the country along with her family. At the airport, Andy attempts to calm the nerves of Shane and Warren. Meanwhile, Silas must decide whether to stay with Lars or leave with the Botwins.

The DEA brings Nancy in for questioning and then she must explain things to Esteban. Celia travels deep into Mexico to make amends with estranged daughter Quinn. Meanwhile, Silas meets Lisa's ex-husband and Doug finds a reason to live. Nancy makes a shocking revelation to Esteban.

Nancy is having one of the worst and busiest days of life. One of sons is missing. Shane's graduation and the deal with U-Turn make her feel like she needs to be in two places at once even though she really doesn't feel like being in either of them. Heylia's plan is put into action. Nancy tries to deal with Conrad's kiss, Celia's madness, and Kat's craziness. Everything comes to a head when the deal goes wrong.

Isabelle experiments, Andy gets drafted, Peter may not be who Nancy thinks he is, Silas gets high, and Nancy cuts out the middleman.

Nancy learns of Esteban's fate and takes action to preserve her own. Andy makes a big change in his life. Dean, Doug and Celia find common ground. Silas helps Adelita with a disturbing medical issue.

Nancy is rushed to the hospital after being shot as the family follows close behind. The family grapples with the tragedy and hypothesizes on the shooter's identity.

As the wildfire approaches, everyone must evacuate. Nancy tells her family to pack up, while Conrad and Heylia must say goodbye to the growhouse. The authorities question Sullivan and Celia, while Shane continues to ask Nancy about Pittsburgh. As Andy deals at the evacuation center, Silas realizes the truth about Tara.

After Bubbie's death, the entire Botwin family sits shiva (the Jewish period of mourning) for seven days. After shiva, Nancy is sent on a mission and takes Andy along with her. Now that shiva is over and Bubbie is gone, Lenny decides to sell the house. Meanwhile, Celia continues her flirtation with Captain Till, and Doug finds refuge with the Botwins.

Guillermo gives Nancy a new job and she soon finds working retail isn't as mundane as it appears on the surface. Celia's deal with Captain Till brings her dangerously close to the action. Meanwhile, having been left in the desert by Nancy, Andy finds himself with a pack of immigrants and a very unfriendly Coyote. Back at home, the boys battle an infestation of bees.

Despite their busy schedules, Nancy and Esteban try to find some time for each other. After finding out about Shane's fantasies and Silas's new and much older girlfriend, Nancy also has to talk to both of her sons. With their relationship going on, Lisa and Silas add some special offerings to her cheese shop.

Andy attempts to impress Jill by coaching the twin's roller-derby team; Doug ponders about his financial future after being forced to resign from the company; Nancy and Silas race to thwart Shane's actions, who is closing in on Tim.

After being threatened by U-Turn and The Armenians, Nancy goes in search of Silas and her hijacked pot. Meanwhile, Celia has Silas arrested for stealing her "Drug Free Zone" signs. Nancy visits him in jail only to discover that the pot is still in his car - the one that Celia has just driven away in.

When Nancy is denied a share of the incoming pot by Guillermo, she decides to go over his head to Esteban. Celia discovers the cheap medication at Mexican pharmacies. Silas and Lisa get intimate, while Shane discovers some shocking photos. Andy and Doug begin interviewing for their human smuggling operation.

A spontaneous date ends in near-violence for Nancy and Esteban; Silas reveals to Lisa that he grows pot, and she makes him a tempting offer; Andy and Doug smuggle their first customer across the border; Celia develops an addiction.

Nancy must deal with the aftermath of Shane's exploits, her Ayahuasca trip, and more confrontation with Guillermo. Celia's struggles with her rehab partner, Barry, force her to find a new rehab facility. Doug and Maria's relationship quickly goes south and they both turn to Andy for help. Meanwhile, Silas's "sandwich" business has grown too big, forcing him to turn to Nancy for help.

Nancy does her best to cope with the loss of Conrad's help, who runs into some trouble while venturing out on his own. Andy is still trying to get into rabbinical school by writing an essay on what being Jewish means to him. And Silas deals with Megan's acceptance to Princeton in his own unique way.

With U-Turn's timely demise Nancy and Conrad check the status on their debts and then they check in with each other. Someone is pregnant and they are keeping it. Doug continues to try to sabotage Celia and Celia continues to sabotage Nancy. Nancy celebrates something. Silas begins spending more time with Tara.

After settling her family in Ren Mar, Nancy turns her attention back to business. Later, Guillermo gives her a much-needed crash course in "running" across the border. Meanwhile, Celia gets further acquainted with life in prison. Lenny leaves Silas and Shane to care for Bubbie while he goes to the track. When Lenny returns, Andy confronts him about some family history.

Nancy makes her first successful smuggling run across the border with both drugs and human cargo. Meanwhile, Captain Till strikes a deal with Celia to get her out of jail. In return, she must gather evidence to incriminate Nancy and Guillermo. Back in Ren Mar, Andy tries to convince the family, including his father, to put Bubbie out of her misery.

Nancy follows the tunnel in the back of the maternity shop and sees something she shouldn't at the other end. Dean takes a new job, leaving Isabelle to live with Celia. Meanwhile, Silas flirts with Lisa, and Doug falls in love with a vision of beauty who washes up on the beach.

Nancy learns that the tunnel is being used for more than drugs. Esteban puts her fears to rest as well as her nagging headache with a strong remedy. Celia's family stages an intervention in order to force her into rehab. Andy finds Maria and takes her across the border to an awaiting Doug. Silas babysits while Shane explores new territory with his two girlfriends.

After showing Esteban the proof of her baby, a sonogram picture. Nancy returns to Ren Mar to her family, but still unsure of her fate. Meanwhile, Celia is held hostage in Mexico by her estranged daughter Quinn who tries to ransom her off to all her friends, but they hilariously decline to deliver the cash for her release. Back in Ren Mar, Andy, Silas and Doug discuss plans to grow pot in a national forest.

Faced with the aftermath of Shane having murdered Pilar, Nancy grabs Shane and Silas and they flee the scene. Andy is then met with the decision to split town with his family or stay and fight for Audra's affection.

After hours of aimless driving, Nancy, ignoring Shane's suggestion of hiding out in Pittsburgh, hatches a plan for the family to cross into Canada. Andy is tasked with acquiring fake IDs. Silas must decide if he's willing to live on the lam. Elsewhere, Esteban must answer to authorities regarding Pilar's murder and Nancy's whereabouts.

Nancy becomes a scab labor in a Seattle hotel while Shane looks after Stevie and Doug goes back to Ren Mar