Maelstrom, a thief who was caught by Carmen during her time as ACME-detective, escapes from prison, swearing revenge on her. At first, it is reported to the detectives that he died during his escape. The detectives are curious about him and The Chief tells them about his adventure with detective Carmen. During that adventure, Carmen and a robot version of the Chief stop Maelstrom from stealing the wreck of the Titanic. At the conclusion of the story, Ivy and Zack find out that Maelstrom is alive and see the opportunity to catch both Carmen and Maelstrom. However, when the detectives sneak aboard Maelstrom's ship, he captures them.

Carmen arrives in the year 2101 where she stops a heist of a powerful electro-magnet. Meanwhile, Zack and Ivy arrive at the future Acme Detective Agency where the wacky Future Chief doesn't recognize them. They try to prove who they are, but run into a few scrapes with the law. Eventually they meet up with Carmen in Africa. Although the detectives expose that she is a criminal, she escapes with the magnet and Zack and Ivy end up captured.

Zack and Ivy escape Maelstrom's ship and find out that Carmen still believes that Maelstrom died in his try to escape from the prison. Carmen wants to give him a worthy Viking-like funeral in Norway. Zack and Ivy find her beginning to give him such a funeral and are about to tell her that Maelstrom is alive when Maelstrom appears in a ship beside Carmen. He challenges her to come after him or die, and then speeds off. Carmen manages to get Zack and Ivy aboard her ship and they make an agreement to join forces to capture Maelstrom. Carmen remembered a clue he left, so she and the detectives follow it to Williamsburg Virginia where Maelstrom captures them and publicly humilates them in the stocks of the town square. Zack and Ivy escape and help Carmen do so as well. They get separated and the local police arrest the detectives for freeing Carmen!

When Carmen attempts to steal several items having to do with military strategies, she is foiled several times by ""The Tigress,"" a thief with a lot of high-tech weaponery of her own. Meanwhile, Zack and Ivy rush into tell Chief something, but he doesn't listen until Carmen starts to listen in on their frequency, so now they can't tell Chief their secret. Every time from that point forward, when Carmen tries to steal something, the Tigress takes it first. The Tigress lures Carmen to Antarctica, where she reveals herself to be Ivy in disguise. Carmen was ambushed by Acme detectives and taken away, but escapes when she steals Ivy's CO2 boots Zack invented, and rockets away.

When Carmen is captured by a judge bent on sentencing her to life in prison, Zack and Ivy are appointed her defense team. Carmen was accused of recently stealing the Magna Carta, which she did not steal. Zack and Ivy try to gather evidence to prove Carmen did not commit this particular crime. But is she really involved after all?

Zack and Ivy discover Carmen's underground training facility and go undercover as henchmen in training to try and nab Carmen. However, Carmen discovers them and leads them to a chamber that seems to have no way out. There is one way- an escape into time. Carmen created another time machine and uses it to escape. The detectives use a new Chronoskimmer that the Chief gives them and they trace where Carmen is heading- the future.

Zack and Ivy escape from the future and follow Carmen to Rome. There, the detectives are captured and are sentenced to fight each other in the Coliseum games. Luckily, they are spared from having to fight each other to the death. They escape, and discover Carmen's plan- she's going to steal the Coliseum! The detectives realize this is part of her plan to become ""the greatest thief of all time"" by stealing objects from the past, present, and future.

The Chief manages to convince the local sheriff to free Zack and Ivy. They meet up with Carmen again and persue Maelstrom. Malestrom begins to steal items and frames Carmen for their thefts! He wants to ruin her reputation as thief with a conscience.

All ACME detectives are making holidays on the Seychelles. Josha, the genius of the detectives, is in love with Ivy but she doesn't notice. When Carmen tries to steal Josha's latest invention, she tries to distract the detectives by stealing highly romantic items.

Somehow, the world's largest diamond, the Star of Africa, was stolen. The police are baffled and it's up to Zack and Ivy to figure this mystery out. They soon discover that one of Carmen's henchmen tried to double-cross her and keep the diamond for himself. With a little trickery of their own, the detectives recover the diamond.

It is reported that Carmen dies in a plane crash. The grief-stricken Chief is unable to help Zack and Ivy solve a series of clues that Carmen left behind to a final caper. The henchman who solves the most of them will be the new leader of V.I.L.E. Zack and Ivy manage to stop all of the thefts. They then travel to the site of Carmen's reported death to pay their last respects. Suddenly, a little bird delivers a message to ""look up."" When they do, they see Carmen was alive all that time. She had planned to fake her death to see who was worthy enough to take her place- and it turns out Zack and Ivy are the only ones who can!

When Carmen is tricked at a heist in China, she decides to get even with a Halloween surprise. She decides to set up a haunted house with items she's recently stolen. Zack is a bit frightened by all the spooky stuff in the house, and has to convince himself it's all fake.

Carmen's henchman Mason Dixon steals her time machine. Suddenly, he is the leader of V.I.L.E. and Carmen is only his henchwoman. Zack and and Ivy have to restore Mason's damage, and also stop him from trying to change the outcome of the Civil War

Carmen's thefts all seem to follow a Wizard of Oz theme. While chasing after Carmen, Zack and Ivy discover that Carmen was an orphan. They trail her to the Golden Gate Girls' School which is about to be torn down. The detectives recover all the stolen objects except for the orphanage. Zack and Ivy see this theft as being almost justified though because it was about to be torn down and was the only home Carmen ever knew.

Zack and Ivy manage to capture Carmen in Hawaii. However, Zack loses his lucky rabbit's foot and begins to believe he's cursed with bad luck. Meanwhile, Carmen escapes and tries to teach her superstitious henchwoman, Hannah Lulu that there's no such thing as curses or ghosts. Hannah has a panic attack though when Zack and Ivy scare her at a supposedly haunted site. They manage to capture her but Carmen escapes. She leaves behind something Zack was glad to see again- his lucky rabbit's foot. He then gives it to Hannah and wonders if carrying around a special Hawaiian plant will give him better luck.

Carmen's reoccurring nightmare sends to her to seek the help of three Native American shamans to interpret it. Meanwhile, Zack, Ivy and a Native American detective named Billy ""Running Bird,"" track Carmen to Devil's Tower where the meaning of her dream is revealed. Though Carmen is captured, the shamans let her go. They do not want to go back on their promise- they would interpret her dream in exchange for the return of the items she stole from them and a promise to not detain her in any way.

When Carmen tries to steal some treasures from industrialist Malcolm Avalon she discovers a painting representing her mother. At the same time Lee Jordan takes the decision to become the new leader of V.I.L.E. Avalon tells Carmen, that the medaillon she has with her, representing the same woman as on the painting, was a gift for his daughter, but he says, that Carmen can't be his daughter because she died in a fire and she would never have become a thief. To convince him she turns herself in to the police. When Lee abducts Avalon, she breaks out again. Lee says, that she will only see her father again if she works for him...

Carmen gives herself a Christmas present by downloading The Chief. Only he's got a virus, and is losing his memory. He thinks that Carmen is still good, and that Zach and Ivy are thiefs.

This was the last episode made, leaving us with the question of if Carmen really found her father, and will she stop her life of crime.

Carmen steals parts of famous artwork to try to create her own personal masterpiece.

Zack and Ivy puruse Carmen to Ayer's Rock where she has brought items of mysterious origins together in an attempt to contact aliens.

Carmen's dream of landing on the moon inspires her to try and make it come true.

Carmen kidnapps two white lion cubs and sets up her own game preserve for them.

The Player challenges Carmen to a low-tech crime. Carmen accepts the Player's challenge and attempts to steal the Orient Express. Zack and Ivy need some help to solve Carmen's clues and are partnered with a gaucho detective named Armando.

Zack and Ivy are partnered with a Russian detective as they follow Carmen's game-like clues to Hawaii for a ""winner-take-all"" chess game.