Ryan fears a future without Wilfred, as his battle with cancer becomes more severe. Drew returns from Wisconsin.

In the second-season finale, existential questions are posed to Wilfred and Ryan.

Season 3 ends with Jenna forbidding Ryan from seeing Wilfred when he needs him most.

Wilfred convinces Ryan to withhold sensitive information from Jenna.

Ryan finally learns his truths about Wilfred and his life.

A crisis arises when Ryan ignores Wilfred's advice.

Ryan subjects Wilfred to a scientific study with unsettling results.

Wilfred's nemesis returns with an offer that rocks Ryan's world.

Wilfred leads Ryan on a crime-fighting caper.

Wilfred crashes Christmas and pits Ryan against his family.

Ryan is put in danger as Wilfred pursues the path to valor.

Ryan learns that life is much more challenging without Wilfred around.

Ryan attempts to discover the truth about Wilfred through self-examination.

A struggle emerges between Ryan, Wilfred and an old friend.

When Ryan's reality is upended, he gets a second chance to make things right.

Ryan forms a unique connection with his neighbor's dog after a failed suicide attempt.

Ryan meets someone who questions Ryan's friendship to Wilfred.

Disaster strikes when Ryan and Wilfred get an unwanted guest on their camping trip.

Wilfred persuades Ryan to help him get rid of Jenna’s boyfriend.

Ryan's resentment of his mother even grows when she moves in and becomes friends with Wilfred.

Wilfred derails Jenna and Drew's wedding because of Ryan's jealousy.

Ryan and Wilfred search for Wilfred’s original owner.

Ryan tries progressive psychotherapy to better understand a past trauma.

Ryan has a guilt complex over the death of his childhood dog, and Wilfred, upon learning of it, goes to otherworldly lengths to help Ryan discover the truth about how the pooch passed on. Meanwhile, Kristen throws a party for her boss.

Wilfred tries to find Ryan a human friend.