Ryan fears a future without Wilfred, as his battle with cancer becomes more severe. Drew returns from Wisconsin.

Ryan and Wilfred make an extraordinary effort to boost Jenna's career.

Ryan has to deal with new problems when Wilfred becomes popular.

Wilfred's nemesis returns with an offer that rocks Ryan's world.

Season 3 ends with Jenna forbidding Ryan from seeing Wilfred when he needs him most.

Wilfred convinces Ryan to withhold sensitive information from Jenna.

Ryan finally learns his truths about Wilfred and his life.

A crisis arises when Ryan ignores Wilfred's advice.

Ryan attempts to discover the truth about Wilfred through self-examination.

Wilfred muddles Ryan's plan to introduce Amanda to Jenna.

Ryan subjects Wilfred to a scientific study with unsettling results.

Ryan learns that life is much more challenging without Wilfred around.

When Wilfred comes to the conclusion Ryan is the only beneficiary of their friendship, he denies Ryan any further help.

Ryan is forced to intervene when Wilfred becomes embattled with an unlikely foe.

Unexpected problems arise for Ryan and Wilfred after a traumatic experience.

A spontaneous road trip proves disastrous for Wilfred and Ryan.

Wilfred leads Ryan on a crime-fighting caper.

Wilfred crashes Christmas and pits Ryan against his family.

Ryan is put in danger as Wilfred pursues the path to valor.

Wilfred derails Jenna and Drew's wedding because of Ryan's jealousy.

In the second-season finale, existential questions are posed to Wilfred and Ryan.

A struggle emerges between Ryan, Wilfred and an old friend.

When Ryan's reality is upended, he gets a second chance to make things right.

Ryan forms a unique connection with his neighbor's dog after a failed suicide attempt.

Ryan meets someone who questions Ryan's friendship to Wilfred.