Ryan helps his mother adjust to her new life as Wilfred deals with a new nemesis.

Ryan distrusts his sister's new love interest.

Ryan finds a roommate with Wilfred's help.

Ryan and Wilfred take sides in Kristen's custody battle.

While trying to uncover who his father was paying off, Ryan runs into Bruce, only to be a pawn in his next game.

Wilfred derails Jenna and Drew's wedding because of Ryan's jealousy.

Wilfred is angry after Ryan tricks him into going to the veterinarian.

Ryan gets his wallet back (that's the good news) when his malevolent, porn-addicted neighbor Spencer shows up. The bad news? Spencer's looking for answers about who broke into his house. He's also looking for blood.

Ryan tries to reconcile with his sister, and Wilfred is in for a shock at doggy day care as a result.

Wilfred reveals an extraordinary ability when Ryan takes him to a hospice to volunteer.

Ryan must swallow his pride when Wilfred pursues a new love interest., and Ryan meets a new romantic interest himself

Ryan befriends Wilfred’s enemy—the mailman.

Ryan takes Wilfred to a dog training class in the hopes of winning over a girl.

Wilfred forces Ryan to collaborate on a birthday gift for Jenna.

Ryan has a guilt complex over the death of his childhood dog, and Wilfred, upon learning of it, goes to otherworldly lengths to help Ryan discover the truth about how the pooch passed on. Meanwhile, Kristen throws a party for her boss.

Wilfred tries to find Ryan a human friend.

Just as Ryan finds happiness in his life, Wilfred begs him to sacrifice it for a larger purpose.

Wilfred pursues a forbidden love.

Ryan and Wilfred have drastically different accounts of the same disturbing incident.

Wilfred persuades Ryan to help him get rid of Jenna’s boyfriend.

Ryan's resentment of his mother even grows when she moves in and becomes friends with Wilfred.

Ryan learns that life is much more challenging without Wilfred around.

When Wilfred comes to the conclusion Ryan is the only beneficiary of their friendship, he denies Ryan any further help.

Ryan is forced to intervene when Wilfred becomes embattled with an unlikely foe.

Unexpected problems arise for Ryan and Wilfred after a traumatic experience.