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A brutally bashed cabbie and his assailant come face to face in the ED creating a medical mystery for Steve; a Bride arriving in the ED instead of her church inadvertently gets Bart and Amy working together; and Mike has difficulty juggling new directions in both his personal and professional lives.

It’s the first day of official operation for Mike’s MRU team, and the adrenaline is pumping as they are called out to a precarious rescue in the National Park. Two paragliders have come to grief on a remote cliff-face, and a daring vertical rescue is soon in operation.

Steve is confronted with demons from his past when he attends a car accident involving Gabrielle's father and brother. Meanwhile, all is not what it seems with a patient and her husband, and Bart finds himself in an impossible situation.

Time runs out for the Medical Response Unit when a simple rescue escalates into an horrific tale of despair involving children. Meanwhile, Bart and Amy once again come to loggerheads when they try to deal with a manic patient who refuses treatment. Then, Frank turns to hands-on care with a patient whose life force is being sucked out of her by the pressures of 21st century living.

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Clare is terrified when her past finally catches up with her, while Adam helps a seriously ill woman confront her feelings of guilt — and learns some home truths about himself in the process. Then, the MRU team's rescue of a man trapped in a scaffolding collapse is compromised by a pre-existing medical condition.

Steve puts himself in grave peril at the scene of a domestic siege when he ignores MRU protocol and enters the house where a young man has taken his parents hostage. Claire's past continues to menace her when Ian returns to confront Claire. The argument results in Ian collapsing and Claire is forced to get him the medical help he needs. The man she fears is, once again, a patient in her ED. While nursing Ian, Gabrielle comes to understand more about Claire's relationship with Ian, and the genuine grounds for her fear of him. Bart's sensitivity and wise counsel to a young woman who has suddenly found herself unable to have sex with her boyfriend causes Amy to see him in a different light.

A psychotic patient on an Ice rage turns the ED into a danger zone. Frank goes to extreme lengths to uncover the deadly secret he's hiding. But will it be in time? An explosion at a winery puts the MRU's teamwork to the test and sees Jo form a strong bond with a young woman with whom she has much in common. Bart's rejection of Amy lands him in very deep water with Frank who finally gets an insight into Adam's past.

Violence has resulted in Mike, Steve and Jo fighting desperately for the life of a man crushed in a car compactor. Claire's fear of Ian, her old boyfriend, turns into her worst nightmare. A casual affair turns a man's life upside down when the woman takes drastic action to keep him.

When Steve calls in sick, Mike and Jo have to crew the MRU Unit alone, finding themselves in a situation that tests them to the limits. Steve and Gabrielle care for Claire after she has been sexually assaulted. Frank, Bart and Amy struggle to save a young man who has sustained brain damage, and help his mother with a terrible decision. Then, Charlotte and Von have to deal with a patient who pushes them to the limits.

Steve's anger at being unable to help Claire in the aftermath of her rape creates tension with his workmates and patients. A female prisoner who deliberately swallowed a toothbrush for a day out of gaol opens up the past for Claire and Adam in a surprisingly similar way. Mindless violence at a teenagers' soccer match spills into the ED.

Bart has to think outside the square to help a well travelled patient who is suffering from a mysterious infection. Tragedy strikes a young girl who comes in with breathing difficulties. Steve makes a connection with a woman trapped in a motor vehicle, while Claire develops a similar rapport with the victim's best friend.

A devastating bus crash impacts heavily on the MRU team. Adam's past affects his treatment of a mentally ill patient. Von becomes the meat in the sandwich between Adam and his mother.

A life threatening rescue in a grain silo appears to be the straw that finally breaks invincible Jo. Meanwhile, an elderly man presents with serious symptoms which turn out to be connected in the most unexpected way. Plus, a young sportswoman appears to have an eating disorder but the truth of her situation proves far more devastating.

The MRU find their lives in danger, when Ian returns on a mission to win Claire back and get Steve out of the picture once and for all. Amy is far from thrilled when someone from Bart's past turns up as a patient. Frank's fear that he is losing his passion for the ED has him thinking about a possible career change.

Frank is forced to make a decision about his future. Amy gets some home truths from a patient with a rare infection and a broken heart. Charlotte and Von treat a woman who's allergic to the world around her. Mike bonds with a man trapped by his own fear of change as well as some high voltage electrical cables

Frank is looking for new direction and starts the day in a disturbingly good mood. Meanwhile, Bart is stumped by a home renovator's mysterious deterioration. Plus, Amy and Charlotte treat a woman who risked her life for a tree and the MRU team is called out to treat a man whose sexual fantasy has got him into a tight spot.

Frank's intern program gets off to a shaky start with the ED's newest recruit giving Frank more than he bargained for. Meanwhile, Adam's sent into a spin when his mother turns up wanting to start over and a father and daughter's lives hang in the balance when a weekend away turns to tragedy.

When a patient's life is destroyed by alcohol, Gabrielle pushes Steve to a decision that will have a devastating result. Meanwhile, a new intern reveals her hidden skills to Frank when she intervenes to save a surfer from paralysis, and a young patient's well laid plans are threatened by a devastating illness, causing Bart to reassess his life.

A pregnant cult member's rare allergic reaction puts her life, and that of her baby, in grave peril. Steve and Claire come to the end of their road, via very different paths. Frank finds doing an easy favour for a colleague much harder than he imagined.

Adam faces death when mindless violence spills into the All Saints ED. Meanwhile, Frank accidentally discovers the appalling secret Katerina is carrying and Von is presented with the opportunity of re-evaluating her relationship with Adam when she deals with a grief-stricken mother.

Jo is pulled out of her comfort zone when she falls for Declan, a stuntman at the centre of an accident involving multiple injuries. Steve comes under fire when he fails to notice a patient under his care has critical injuries. Frank is forced to question his motivation for helping Katerina. Von makes a heartbreaking decision where Adam's welfare is concerned. Amy and Bart are affected by the plight of a young woman who suffers from an extraordinary illness. Charlotte helps an elderly patient realise that sometimes the worst things that could happen, turn out to be the best.

The MRU are called out to the same location twice after a local butcher abuses his position of power. Meanwhile, Adam and Von help a pregnant schoolgirl whose situation is more complex than first thought, and a journalist proves a handful for the staff. Also, the blossoming love between Jo and Declan is threatened when Mike starts to suspect Declan may have a serious undiagnosed condition.

Frank is in danger of losing his perspective on Katerina as she deals with a punch-drunk patient. Meanwhile, Jo's boyfriend's rejection to having a medical before his next stunt, leads her to confront her own fears, and sisters fighting over their mother's life have a profound effect on Von.