Connor stands in for Kate on a quiet night on the ward. He and Bron fool around as Jared tries to study, but then things start to go wrong. Meanwhile, Von watches her friend Kate finally succumb to the horrors of alcoholism.

While Ben and his new partner, Scott are trapped in the path of a deadly blaze, the hospital staff are crying out for a cool change. Terri makes a big decision about her future while nursing a man with severe burn injuries and Connor finds it difficult working with Bron after his attempt to woo her fails.

When two teenagers are brought onto the ward after a home-made bomb explodes at a State Boy's Home, their different attitudes lead to a number of wrong conclusions being drawn. Bron is frustrated nursing a developmentally delayed young woman with an unquenchable thirst who will only listen to instructions from Mitch. Jared searches the ward for a mouse unaware it belongs to a patient, sort of. Rose returns to work, with the added emotional stress of leaving her baby in the crèche for the first time.

Connor, Bron and Jared don't know what has hit them when they come up against Terri's replacement, Kate Larsen. They soon realise that this nursing unit manager has very different ideas about how Ward 17 should be run.

The rapist strikes again, kidnapping Bron and leaving a young nurse dead. In mortal danger, Bron is shocked when she discovers the identity of the serial rapist. Ward 17 is threatened with quarantine after a breakout of golden staph. Luke is forbidden to operate on patients after being suspected as a carrier.

Terri is in tears over Connor's departure and as Mitch comforts her their true feelings for each other surface.

Von never makes it to the charity ball when her little friend Zac's condition begins to deteriorate. Terri and Malcolm bond at the ball but Terri is shocked to discover Rose suffers from bi-polar. The revelation causes problems between Mitch and Rose. Kylie drinks too much, Scott puts more moves on Andrea and Luke's date is horribly raped outside the ball venue. Meanwhile, Connor and Bron are on night shift in Ward 17.

Scott puts his life and his job on the line to save the victims of a gunman's violent rampage through a quiet suburban street.

Von has spotted what is going on between Mitch and Terri. Mitch is conveniently preoccupied with a mysterious bond between twin patients.

Nelson Curtis, a nurse practitioner and Paula Morgan, a registered nurse are employed in two new permanent positions on the ward. Malcolm questions Von's competence as a nurse and whether or not she should be taking care of a patient with complications from a caesarean. On his way home, Mitch is witness to a terrible car crash. A delusional Rose contacts the Ward when Mitch fails to arrive home and alarms Terri, who must choose whether she wants to take the job at Stanford University. Terri finds Rose, unconscious with her life hanging in the balance.

In the late stages of a terminal disease and 38 weeks pregnant, Sarah wants to go home to organise her daughter's fifth birthday party. When she goes into labour in the ambulance, a battle ensues to keep mother and baby alive. Jared is forced to make a decision about his career. Connor, Bron and Kylie prepare to celebrate Jared's birthday.

Sarah's health is failing fast and the fight to keep her alive through the compensation case is taking an emotional toll on Mitch and Kate. Bron's gambling debts land her in trouble with a loan shark. Tempers fray between Scott and Ben when they are called to a biscuit factory where a worker has collapsed.

Things are typically hectic in Ward 17 as Kylie is involved in a car accident after the end of a protracted stint at the hospital. After suffering minor injuries, Kylie struggles to treat the driver of the other car. Bron is nursing 16-year-old Jacqui Henderson, a fit, young runner who collapsed while jogging to school. Mitch soon discovers Jacqui has pericarditis — heart disease. It is unusual in someone Jacqui's age, especially as she is so fit. Meanwhile, Terri must deal with a patient's unbroken repetition of the same song but after getting the elderly woman to stop singing, her condition rapidly deteriorates.

Mitch diagnoses a gifted ballerina with scoliosis, forcing her to make a choice between her health and a career. Bron is looking after Brett Addison, a former patient who is booked in for spinal surgery. Connor surprises Jodi with flowers and finds her reaction not at all what he expected.

Ben and Scott receive a call-out to a low security prison and arrive to find a siege in progress with a guard, a nurse, and another inmate hostage in the prison clinic. Connor's day does not start well when a post-op patient pleads to be allowed out of bed and subsequently falls over — Luke then becomes irate at Connor's apparent lack of patient care. After nursing a life coach, Connor also starts to examine his own life. Terri reveals to Von that she is worried Dr. Pussle will want to progress the relationship faster than she can handle.

Scott is put to the test when Ben blacks out on the job. An emotionally distraught Bron then puts Ben's life at risk by undermining Luke's confidence before surgery. A man's life is thrown into turmoil when told he is terminally ill, only to later discover that there was a mix-up and he isn't going to die.

Connor is speechless when he bumps into Jodi pole-dancing in a club. Terri finds another nurse rape victim and to Von's surprise, the battle-axe she is nursing turns out to have the key to soothing the rape victim's pain. Mitch is driven mad by Rose's mother. While Terri would love to help, Mitch makes it clear that she's the last person who can do so. Luke pulls off a tricky operation.

An exhausted Jared is making mistakes on the job and tragically risks Terri's life. Terri's accident is potentially fatal and for Mitch, this is almost the end of a bad day. Mitch receives some devastating news. A man suffering with tumours from second generation Agent Orange Syndrome looks to euthanasia for a way out.

Rose leaves baby Lucy at home alone and is later found playing on a swing in a park at midnight in the pouring rain. After a frightening night of Rose's behaviour, a confused and extremely worried Mitch turns to marriage counselling. The strain is showing, particularly in Mitch's unusually gruff treatment of patients. Bron is stalked and then trapped by the nurse-rapist in the hospital boiler room. With no way out, she knows she must fight for her life. Ben finds the tragic results of a three-year-old boy who was left alone while his mum played the poker machines. Shaken by a distressing day at work, Ben is late in picking up Bron, only to find her missing. Luke and Terri are confronted with the horrifically cruel results of a school initiation.

Terri returns to Ward 17 and is amused to find Mitch's new boss is his former intern Malcolm Pussle, who once had a huge crush on her. Connor's mate, former Ward Clerk Tony Hurst, returns from the States after being dumped by his American boyfriend and is destroying himself with drugs and alcohol. When he has a respiratory arrest, he is admitted to All Saints, and Connor tries to persuade Tony that people do care for him. Mitch clashes with Malcolm over treatment of a young man who believes he is a vampire. Bron nurses Vietnam veteran Brian Douglas who, after surviving prostate cancer, caused by exposure to Agent Orange, wants to march with his mates on ANZAC day. Mitch has to break the sad news his cancer has returned and he doesn't have long to live.

Connor wrestles with the fear that his mother has contracted a very serious illness , with the rules of patient confidentiality, and with the suspicion that his brother or his mum's boyfriend is responsible for her illness. Bron confronts her own issues with her childhood and her father when a young man is admitted after slashing his wrists. The father seems completely uninterested in visiting him or communicating with him in any way. Scott organises a birthday treat for Ben — a raunchy on-stage tango with a lingerie waitress.

Bron and her patient, a self-help motivationalist, both have an influence on each other's lives and Bron's relationship with Ben takes an unexpected turn. Ben treats a man who is drinking himself to death and finds himself remembering Stephanie — wondering if it is time he moved on. Terri and Mitch fight for the rights of a hunger striker who claims to be a victim of political oppression.

Mitch diagnoses a strong-willed bag-lady with severe gangrene. When she rejects medical attention, Mitch finds it hard to respect her decision to return to a life on the streets because it means certain death. Bron nurses Steve, a young Australian backpacker who has lived with epilepsy for most of his life. After a failed lunch date Ben finally catches up with Bron. Jared arrives at work to discover the medical fundraiser calendar in which he appears near-naked has gone on sale.

Pussle and Terri's future together is uncertain after Mitch and Pussle's arguments over a patient force their mutual jealousy over Terri out into the open.

Ian Hanrahan arrives to undergo corrective surgery for a minor hernia. However, things do go badly wrong when Ian has a completely unforeseen reaction to the anesthetic. Ian comes out of the routine operation in a vegetative state and there seems to be little hope of any improvement. Ben and Scott are called out to attend a young woman who has collapsed, in extreme pain, at a train station. Meanwhile, Bron is battling with a difficult patient who, despite being discharged, is refusing to leave hospital.