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A worker from a car parts factory, brought into the ED after an explosion at her workplace, is discovered to have a bizarre but deadly injury that could spell disaster for her as well as the entire Emergency Department. The scenario takes all of Frank and Mike's ingenuity and courage to come up with a solution. And that solution will see Mike putting his life on the line, giving him reason to make a radical decision about his future. A young woman, Morgan, is suffering from severe hypothermia after a camping trip went wrong and the ED team wrestle with balancing the risk of cardiac failure over the risk of brain damage. Bart, however, has his own agenda in play and Charlotte fears he isn't doing himself or the patient any good as a result. Adam's persistence with a "Frequent Flyer" patient puts him at loggerheads with both Frank and Gabrielle. Frank is surprised by a visit from Amy, his niece, who wants her job in the ED back.

Katerina goes to drastic lengths to win back Frank's approval. A tragic accident makes Jo reassess her priorities.

When a young pregnant woman is admitted after collapsing, the team are faced with a moral and ethical dilemma when they discover who the father is. A man is brought in having been bashed. What first appears to be a random act of violence turns out to be much worse. Erica meets Dan's parents, but doesn't get the warm welcoming she'd hoped for in a day that ends in tragedy with the Goldmans racing a family member to hospital.

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A traumatised Charlotte brings Rhiannon into the ED after Rhiannon has attempted to end her life. As Frank, Jack and Gabrielle battle to save Rhiannon's life, Charlotte confronts the one person she thinks caused it all — Rhiannon's father. Erica and Steve are kept in the dark when Von and Mike take over the illegal refugee, Nadir's case. Faced with the prospect of their actions being discovered, Von and Mike take unprecedented action to keep all those who come in contact with Nadir, in the dark. Dan and Bart deal with a patient who has to make a life/death choice. The mother of the patient finally has to accept that her son is the only one who can make this choice and once she does, Dan learns what Bart has already learnt — that sometimes love equals letting go. With renewed commitment, Dan finally confronts his mother who has been battling out wedding plans with Erica's mother and only adding to the tension of getting married.

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A life threatening rescue in a grain silo appears to be the straw that finally breaks invincible Jo. Meanwhile, an elderly man presents with serious symptoms which turn out to be connected in the most unexpected way. Plus, a young sportswoman appears to have an eating disorder but the truth of her situation proves far more devastating.

A pregnant cult member's rare allergic reaction puts her life, and that of her baby, in grave peril. Steve and Claire come to the end of their road, via very different paths. Frank finds doing an easy favour for a colleague much harder than he imagined.

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Frank's leadership is put to the ultimate test when the ED team is held hostage and a deadly plan unfolds. In the bedlam that follows, threats are made, tempers are stretched and lives are lost. And at the end of it, Frank makes a decision that looks likely to cost him his job.

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Dan, Erica and Jack are running late for work when they find a middle aged woman on the bonnet of Dan's car. After she is taken via ambulance to All Saints, it is soon discovered that her incoherence and her physical frailty are the result of Huntington's disease. In treating her and in talking with her daughter, Dan comes to an important decision about his own health. Charlotte, Erica and Jack treat a young man struggling to come to terms with what he has done to his body. On his first day back at work, Mike is thrown into the middle of a major trauma. Bart comes into the ED to announce that Ann-Maree died the night before. The ED is stunned to learn the news about Frank's sudden resignation.