Multiple stabbings, suicide attempts, a double shooting and an explosion at a flat flood the control centre of the London Ambulance Service with emergency calls threatening to overwhelm the service.

We join the staff in the nerve-centre control room on the night shift. Amongst the thousands of calls they receive, they also have to contend with hoaxers, frequent callers and run-away patients.

The staff of the London Ambulance Service prepare for another busy weekend. Amidst the call-outs to drunken fights, drug overdoses and stabbings there are also five women going into labour and a miscarriage to cope with.

It is Saturday night and Katie and Sarah race to help a man who has collapsed at home. By midnight, revellers spilling out of bars and clubs start to impact the service as calls flood in of brawls and accidents.

1 hour into the night-shift the control centre is already onto its 3rd cardiac arrest and the 12th stabbing victim of the weekend. Other crews are tied up caring for an alcoholic and an elderly man.

A crew are dispatched to attend to a woman complaining of stomach pains, but she has actually suffered a massive heart attack. Terminal cancer patient Nigel is philosophical about his life.

Jo and Suki are involved in high drama as they take a patient to hospital when a car crashes right in front of them. Call-handlers deal with two suicidal patients. In Birmingham a woman has had her finger bitten off.

The air ambulance is dispatched to a woman struggling to breathe after falling, but the helicopter is soon also needed at a road accident in Staffordshire. Reports of a hanging come in but is the call a hoax?

Justin and Dawn's first call of the day is to a woman whose waters have broken. A drunken man, repeat callers and a woman unable to leave her home all test the crews patience.

Crews in the more rural areas covered by the service are called out to an elderly couple, a train-spotter who has fallen and banged his head and suicidal patients.

The West Midlands Ambulance Service have to deal with the fatal consequences as Storm Doris batters the UK. Gale force winds are causing accidents, blocking roads and grounding the air ambulance.

Over a busy weekend in Manchester, North West Ambulance Service paramedics Andrea and Glynn attend an RTC, while Debbie and Shaun try to persuade a homeless man to go to hospital.

During a 12-hour night shift with North West Ambulance Service, call handler Elly tackles an increasing volume of calls, and there are surprises for paramedics April and Clare.

A suspected terror incident requires a large-scale response and brings back memories of the Manchester Arena attack for the paramedics.

West Midlands Ambulance Service must manage problems of a winter NHS crisis that has left patients queuing in the corridors of Royal Stoke Hospital.

A Friday night shift takes an unexpected turn for paramedic Jon. A panicked caller needs help for a friend who has given birth in a hotel room despite not knowing she was pregnant.

Call handler Joe faces his first unsupervised shift answering 999 calls on a busy night for the North West Ambulance Service.

A Friday night shift takes an unexpected turn for paramedic Jon. A panicked caller needs help for a friend who has given birth in a hotel room despite not knowing she was pregnant.

This episode follows staff on a Friday night shift. Saj, the performance manager, is concerned there aren’t enough ambulances for all the patients needing them.

The North West Ambulance Service prepares for England's meeting with Croatia in the World Cup semi-final. As the country comes together in hope and excitement, the crews nervously anticipate the increase in calls that will follow no matter what the result.

While most enjoy a hot May bank holiday weekend in Manchester, North West Ambulance Service paramedics Gary and Claire need face matters of life and death.

Call handler Laura offers life saving advice to a panicked 999 caller, the call makes such a deep impact that she decides on the spot to change the direction of her life.

As senior paramedic Rich waits for his first job, he comments on the increase in homelessness in Greater Manchester. A category one response is needed for a man lying unconscious on the street because it is believed he has taken synthetic cannabis.

Doctor Ian and paramedic Nikki see the human consequences of youth violence when they attend a 13-year-old who has been stabbed and two young men who’ve been shot.

North West Ambulance Service faces the pressure of the busiest day of the winter so far with an overwhelming volume of calls and severe delays handing over patients in hospital.