Multiple stabbings, suicide attempts, a double shooting and an explosion at a flat flood the control centre of the London Ambulance Service with emergency calls threatening to overwhelm the service.

We join the staff in the nerve-centre control room on the night shift. Amongst the thousands of calls they receive, they also have to contend with hoaxers, frequent callers and run-away patients.

The staff of the London Ambulance Service prepare for another busy weekend. Amidst the call-outs to drunken fights, drug overdoses and stabbings there are also five women going into labour and a miscarriage to cope with.

It is Saturday night and Katie and Sarah race to help a man who has collapsed at home. By midnight, revellers spilling out of bars and clubs start to impact the service as calls flood in of brawls and accidents.

1 hour into the night-shift the control centre is already onto its 3rd cardiac arrest and the 12th stabbing victim of the weekend. Other crews are tied up caring for an alcoholic and an elderly man.

A crew are dispatched to attend to a woman complaining of stomach pains, but she has actually suffered a massive heart attack. Terminal cancer patient Nigel is philosophical about his life.

Jo and Suki are involved in high drama as they take a patient to hospital when a car crashes right in front of them. Call-handlers deal with two suicidal patients. In Birmingham a woman has had her finger bitten off.

The air ambulance is dispatched to a woman struggling to breathe after falling, but the helicopter is soon also needed at a road accident in Staffordshire. Reports of a hanging come in but is the call a hoax?

Justin and Dawn's first call of the day is to a woman whose waters have broken. A drunken man, repeat callers and a woman unable to leave her home all test the crews patience.

Crews in the more rural areas covered by the service are called out to an elderly couple, a train-spotter who has fallen and banged his head and suicidal patients.

The West Midlands Ambulance Service have to deal with the fatal consequences as Storm Doris batters the UK. Gale force winds are causing accidents, blocking roads and grounding the air ambulance.

A day shift takes an unexpected turn for West Midlands Ambulance Service paramedics, Nat and Nat, when a 999 call about an unconscious patient suddenly becomes very personal. In the meantime, a 19-year-old girl has been taken ill at school.

New Year's Eve is the busiest shift of the year for West Midlands Ambulance Service. Extra staff is brought in to care for those in need, but the night does not go as planned.

Pete and Matt, a specialist trauma team, are called to treat the victim of a brutal knife attack. Paramedics Christine and Chris start their day shift with a man who has collapsed in Worcester town centre after a suspected drug overdose. Jo and Tracey are called to 90-year-old Dennis, who's been vomiting. Christine and Chris are dispatched to Theresa, a terminally ill patient with suspected neutropenic sepsis caused by her cancer treatment. Crewmates Mark and Nieaal drive 20 minutes on blue lights to Ledbury in the dead of night to treat 96-year-old Jim.

Nina and Lauren respond to a caller whose mother has stopped breathing and is in cardiac arrest. The call handler in the control centre gives CPR advice over the phone while paramedics travel on blue lights to the scene.

At the start of a night shift, West Midlands Ambulance Service is receiving a High volume of emergency calls and is struggling to cope. A specialist paramedic attends a machete attack but his less urgent jobs are even more time-consuming.

The last Saturday before Christmas is a busy, with controller Sui having to prioritise stabbing victims and reports of drowning over patient's like Betty, whose daughter says she's fine but needs help getting up having fallen to the floor.

Over a busy weekend in Manchester, North West Ambulance Service paramedics Andrea and Glynn attend an RTC, while Debbie and Shaun try to persuade a homeless man to go to hospital.

During a 12-hour night shift with North West Ambulance Service, call handler Elly tackles an increasing volume of calls, and there are surprises for paramedics April and Clare.

A suspected terror incident requires a large-scale response and brings back memories of the Manchester Arena attack for the paramedics.

West Midlands Ambulance Service must manage problems of a winter NHS crisis that has left patients queuing in the corridors of Royal Stoke Hospital.

A Friday night shift takes an unexpected turn for paramedic Jon. A panicked caller needs help for a friend who has given birth in a hotel room despite not knowing she was pregnant.

Call handler Joe faces his first unsupervised shift answering 999 calls on a busy night for the North West Ambulance Service.

A Friday night shift takes an unexpected turn for paramedic Jon. A panicked caller needs help for a friend who has given birth in a hotel room despite not knowing she was pregnant.

This episode follows staff on a Friday night shift. Saj, the performance manager, is concerned there aren’t enough ambulances for all the patients needing them.