A sick lady with a monkey provides the key to a mysterious, highly contagious, and deadly virus that strikes both Dr. Brackett and John. Meanwhile, the firemen rescue a boy from a treehouse and a man from a scaffold.

Returning from a fishing trip, Roy, John, and Chet help the victims of a car accident. On duty, after rescuing some joyriders whose car went over a cliff, John is bitten by a rattlesnake.

Dr. Early is diagnosed with a heart condition and undergoes a bypass. A pro football player is embarrassed to admit that his son tackled him too hard. The firemen rescue a boy trapped in his homemade rocket, a woman with her toe stuck in a bathtub faucet, and an electrocution victim.

Johnny's got another of his brilliant ideas - he wants Station 51 to buy a nearby hot dog stand. Roy, as usual, is the wet blanket - but this time his caution pays off. The paramedics help a man injured while mowing his lawn and rescue the victims of a fire at a chemical factory.

A woman passed out in a bar is suffering from more than drunkenness. Johnny becomes the victim of a hit and run accident and is a terrible patient. Worse, his replacement Brice annoys everyone at the station. The paramedics help a heart patient and fight a fire in an abandoned building where Roy, Brice, and Marko are trapped.

Roy and John try to go fishing in Santa Rosa County, but are delayed when they rescue climbers from a cliff face and a fishing boat blows up. They help the sheriff come up with ideas for implementing emergency medical services in his county

Gage tries to create his own television game show. An elderly musician experiences heart trouble. When a car runs a stop sign, three injuries result. A tightrope walker gets stuck between two buildings.

When Johnny's policeman friend is injured in a car crash, the paramedics can't reach the hospital because another squad is using the biophone. A child with a mysterious malady turns out to be drunk. Roy and John assist at the hospital when the victims of a motorcycle gang war are brought in for treatment. An artist becomes trapped in his own sculpture. A father and son are trapped in a collapse at a construction site.

A documentary crew follows the paramedics as they rescue a teen-aged snakebite victim, help a dangling stuntman, retrieve a boy who fell off a cliff and rescue a driver from a truck fire.

Millie Eastman, once head nurse at Rampart but not retired, attempts suicide and finds herself at the hospital she once served. A paraplegic child nearly drowns in a swimming pool. At the hospital, she and Millie form a bond. The paramedics also help a family poisoned by carbon monoxide, a woman wrapped in plastic and a man pinned under a fuel tanker.

Johnny tries to win a ticket-selling contest. Dr. Backett blames himself when he is involved in a car accident that leaves the other driver dead and The driver's daughter refuses to speak. While repairing the squad, the paramedics find themselves in the middle of a shootout and treat a policeman with heart trouble. A boxcar full of ammonia complicates a fire on a pier.

Roy and John are trapped at Station 86 when a rain storm washes out the bridge, and they become the only medical treatment in the area. They assist two victims of an auto accident and a child with bronchitis. Doctors at the hospital treat a policeman hit by lightning. With the aid of a female psychiatrist, the paramedics treat an elderly woman with a hip injury and a man with heart trouble. Copter 15 transports the victims to the hospital, where a power failure complicates matters. Dr. Morton accompanies the paramedics back to Station 86, where they respond to an auto accident with multiple injuries.

Captain Stanley convinces himself he has arthritis. A man gets his hand caught in his garage door opener; a woman passes out and has an auto accident; the doctors treat a woman infected from plastic surgery gone awry; Johnny tests a new type of rope; the station responds to a two-alarm fire at an oil refinery.

Roy and John rescue a man whose engine has fallen on him during his car repair work. When their two-way radio is broken, Roy treats the man without proper medical supervision, causing the man's doctor to attack the paramedic program. Also: a bull gores a motorcyclist, a doctor on a consult at the hospital dies of a heart attack, Roy rescues a child from a house fire.

John gives Chet his guitar. At an explosive structure fire, a girl's horse is trapped in a burning barn. Dr. Brackett and Nurse McCall lecture a man who keeps forgetting his insulin shots. A girl calls the hospital, threatening suicide; firemen stand by while hospital workers attempt to trace the call. A hostage in a bank robbery has heart problems; the paramedics must treat him at gunpoint.

John and Roy are disappointed when they are the only squad not called to a major brushfire. Dixie gets her hand caught in a vending machine. A lawyer collapses in the courtroom with an apparent heart attack. Roy and John finally make it to the brushfire and become trapped while rescuing another firefighter.

Johnny and Chet manage to destroy the station's television, irking the other firefighters. Paramedics rescue a man from a manhole fire. At Rampart, Dr. Morton helps a man with a bleeding ulcer, while Dr. Brackett goes from physician to patient when he has a bad reaction to a catfish bite. A man carelessly glues his own eyes shut, and a mudslide traps Johnny and Roy with the man they came to rescue.

The paramedics complain when a rule forbidding squads to cross each other's territories causes them to come late to an accident scene. An elderly woman is treated at the hospital. While transporting a non-vital patient, the paramedics respond to an auto accident. A prisoner breaks out of jail and gets trapped on a ledge

Richard Bakalyan returns as Charlie, Squad 51's trouble-prone mechanic. The paramedics decide to purchase a boat from Charlie, intendig to sail it on their days off and rent it to others when they're on duty. Of course, things don't quite go as planned, thanks to a wide variety of emergency calls, including the rescue of two boaters from a particularly treacherous stretch of water off Catalina Island, a bookie suffering from a coronary in a locked office, and an explosion in the hospital lab.

Roy passes the Engineer's test, but accepting the promotion will mean leaving the paramedics. A bad fog leads to a multi-car accident on the San Diego Freeway. A young crash victim has a heart murmur. The paramedics have difficulty responding to an attempted suicide. At a structure fire, Johnny is injured and Roy must rescue both him and a security guard.

Gage, flying back to Los Angeles, tries to chat up a stewardess. That's actually good news for another passenger who has a heart attack; she knows right where to find him help. Back at the station, the firefighters respond to a motorcycle accident and a chemical fire.

Roy and Johnny rescue a diver. Rampart treats a boy who got a severe stomach ache from eating raw dough, while the paramedics rescue a diver from a tank, and treat a mother/daughter pair: the mother has a heart attack and the stress causes her daughter to go into labor. A fallen electrical wire nearly ends Captain Stanley's career.

Captain Stanley is dismayed when he learns one of his former commanding captains is now his Battalion Chief, causing the others to worry about his increased paranoia. Two men's carelessness starts a fire at a gas station. A new hospital administrator causes problems. A woman accidentally shoots her husband with a nail gun. Two clowns start a fight at an ice rink. A car leaves an overpass and crashes into a transfer truck filled with pesticides.

Roy's mother-in-law is scheduled for her annual visit. A car runs into the back of a truck. Drs. Brackett and Early argue over attending a convention in Acapulco. An elderly man becomes ill from drinking a quack's remedy. When a fire breaks out in a hospital room, the occupant goes into cardiac arrest. A boy's model rocket sparks a house fire.

Station 51 is called up to fight a wildfire. John and Roy rescue an elderly woman and her sister, treat an injured fireman, deliver a baby, catch a looter, and find a boy's lost dog.