Stan tries an experimental pill from the CIA and turns into a girl. Meanwhile, Klaus and Roger start a business selling Stan's suits as he no longer needs them as a female.

Steve’s life is turned upside down when Snot gets rich after his mom starts selling a new dipping sauce. Klaus, Stan, Roger and Jeff become mall fashion show models.

Roger helps Francine with her terrible cooking by bringing her to a remote Patagonian island. Stan gets a nail in his head and can’t speak.

Steve babysits Roger’s ex-tumor, Rogu, to prove to Francine that he’s ready for the responsibility. Stan and Francine get into trouble in their respective clubs.

Stan, reluctantly invites Roger into his ham club. Francine decides to scare Greg.

Roger helps Stan enter Francine’s dreams after he becomes insecure about their contents.

Steve goes undercover as a school hall monitor; Roger and Stan go catatonic after witnessing a grisly escalator accident.

Steve introduces Stan and Francine to Barry's parents and Steve regrets it. Roger goes blind.

Steve tries to get into baseball to connect with Stan. Roger creates real life drama for Francine after her favorite soap opera is cancelled.

Francine tries to be a better friend to one of Roger's personas who is selling her homemade jeans on TV. Stan and Steve swap eyebrows.

Roger breaks up Steve's friendship with Snot, Barry and Toshi. Jeff realizes he has a flair for house flipping and gets Stan, Francine and Hayley involved.

Stan buys the rights a Broadway show after inheriting money from a dead uncle.

Roger tries to force Hayley into graduating from community college so he can move into her room. Klaus repairs Francine’s car.

Klaus leaves the family after one too many harassments. 15 years later, they reconnect for his funeral.

Jeff is forced to take Francine out for a not-so-wild night on the town. Klaus forces Steve to watch his celebrity impressions.

Thanks to Roger, Snot discovers his dead father was a demolition derby driver. Hayley takes Steve on a road trip, so he can learn to drive.

Francine helps Hayley take a break from their marriages. Stan and Jeff pretend to be frontiersmen.

Hayley and Jeff move into a van and start living life on the open road. Francine and Steve are haunted by an Uber driver that they rated poorly.

American Dad becomes the 25th scripted primetime show in the History of Television to reach 300 episodes and Roger's past comes back to haunt him.

Francine and Stan swap spouses with their gay neighbours Terry and Greg when Terry's dad, a former football player who doesn't know that his son is gay, arrives for a visit. Meanwhile, Steve goes on a drunken bender.

Stan has Roger pretend to be a shark to help Steve overcome his fears. Hayley's friend Danuta becomes romantically interested in Klaus.

Stan's co-workers at the CIA teach him about "rubbernecking," the art of checking out other women on the sly, away from the gaze of their wives. But when Stan causes a massive accident in an attempt to take a picture of an attractive jogger, he's interviewed by an intimidating insurance inspector who may rat out Stan to Francine. Meanwhile, Roger and Klaus spill wine on the Smiths' brand new couch, and vow never to tell the other family members by sitting on the stained spot for the rest of their lives.

Jeff wins a tour through a mysterious weed factory and brings Stan along.

When the family goes to a dude ranch, Klaus and Rogu have to work together to survive in the wilderness.

Francine is jealous of the new and improved Klaus and vows to take him down.