Stan tries an experimental pill from the CIA and turns into a girl. Meanwhile, Klaus and Roger start a business selling Stan's suits as he no longer needs them as a female.

American Dad becomes the 25th scripted primetime show in the History of Television to reach 300 episodes and Roger's past comes back to haunt him.

Francine and Stan swap spouses with their gay neighbours Terry and Greg when Terry's dad, a former football player who doesn't know that his son is gay, arrives for a visit. Meanwhile, Steve goes on a drunken bender.

Stan's co-workers at the CIA teach him about "rubbernecking," the art of checking out other women on the sly, away from the gaze of their wives. But when Stan causes a massive accident in an attempt to take a picture of an attractive jogger, he's interviewed by an intimidating insurance inspector who may rat out Stan to Francine. Meanwhile, Roger and Klaus spill wine on the Smiths' brand new couch, and vow never to tell the other family members by sitting on the stained spot for the rest of their lives.

Jeff wins a tour through a mysterious weed factory and brings Stan along.

Francine is jealous of the new and improved Klaus and vows to take him down.

Bullock throws a private, star-studded Christmas party the exact same night as the CIA work party. Stan and Klaus are determined to get in, by any means necessary.

After Greg receives a plaque from the local historical society, Stan goes to great lengths to get the same honor. Roger becomes a traveling salesman.

Thanks to Roger, Snot discovers his dead father was a demolition derby driver. Hayley takes Steve on a road trip, so he can learn to drive.

When the family goes to a dude ranch, Klaus and Rogu have to work together to survive in the wilderness.

Hoping to teach him the value of sharing, the family recreates a television show from Klaus's childhood. Roger has a piano recital.

Stan loses his faith in religion after Steve questions everything in the Bible. He takes the family to Korea to investigate the rumors of a reinvented "Noah's Ark."

Stan and Hayley compete in collecting data for the US Census; Klaus has Steve and his friends model for his new camera.

After a series of boring personas, Roger goes to great lengths to prove to Francine he still has "his edge".

Stan tries a new, cutting edge parenting approach DNA splicing.

Stan discovers that the Langley Falls historical mural has been ruined by graffiti and neglect and convinces the town to allow him to restore the mural himself; Roger becomes Steve's instructor at a prestigious clowning university.

Francine becomes obsessed with home security after a break-in rattles her. Steve tries on Hayley's laidback approach to school work.

Stan and Steve enter an e-sports game tournament to save the world. The rest of the family get stuck in a banister.

Klaus enlists Stan, Roger and Jeff to join him on a wild bachelor party weekend.

Francine explores ASMR with Roger. Steve gets a a pole in his head and a secret admirer.

The Smiths take a trip on an old steam locomotive to visit Francine's aunt only to discover it's being hijacked.

After Hayley is deemed a "big child" by The Lady from The Hamster Rescue Society, she gets involved with two Roger personas who have a complicated family dynamic in an effort to prove that she is an adult woman.

Stan uses a mothballed military computer to do Steve's math homework, starting the clock toward nuclear annihilation.

Francine steals from the CIA and pretends to be a super villain to incite Stan to be more seductive. Meanwhile, Roger tricks Hayley and Steve into trapping Jay Leno so he can take revenge.

Stan is frustrated with traffic so he goes to the mayor and proposes that the town build a bullet train, but the mayor laughs off the idea; Roger pushes Stan into running for mayor; Stan wins the election but finds himself overwhelmed.