Stan tries an experimental pill from the CIA and turns into a girl. Meanwhile, Klaus and Roger start a business selling Stan's suits as he no longer needs them as a female.

Steve’s life is turned upside down when Snot gets rich after his mom starts selling a new dipping sauce. Klaus, Stan, Roger and Jeff become mall fashion show models.

Roger helps Francine with her terrible cooking by bringing her to a remote Patagonian island. Stan gets a nail in his head and can’t speak.

Steve babysits Roger’s ex-tumor, Rogu, to prove to Francine that he’s ready for the responsibility. Stan and Francine get into trouble in their respective clubs.

Stan, reluctantly invites Roger into his ham club. Francine decides to scare Greg.

Roger helps Stan enter Francine’s dreams after he becomes insecure about their contents.

Steve goes undercover as a school hall monitor; Roger and Stan go catatonic after witnessing a grisly escalator accident.

Steve introduces Stan and Francine to Barry's parents and Steve regrets it. Roger goes blind.

Steve tries to get into baseball to connect with Stan. Roger creates real life drama for Francine after her favorite soap opera is cancelled.

Francine tries to be a better friend to one of Roger's personas who is selling her homemade jeans on TV. Stan and Steve swap eyebrows.

Roger breaks up Steve's friendship with Snot, Barry and Toshi. Jeff realizes he has a flair for house flipping and gets Stan, Francine and Hayley involved.

Stan buys the rights a Broadway show after inheriting money from a dead uncle.

Roger tries to force Hayley into graduating from community college so he can move into her room. Klaus repairs Francine’s car.

Klaus leaves the family after one too many harassments. 15 years later, they reconnect for his funeral.

Hayley goes on a rampage after her boyfriend breaks up with her, but she calms down when she begins dating Stan's CIA body double, Bill. Meanwhile, Steve and Roger get jobs separating male and female chicks at a Chinatown hatchery.

Jeff is forced to take Francine out for a not-so-wild night on the town. Klaus forces Steve to watch his celebrity impressions.

Thanks to Roger, Snot discovers his dead father was a demolition derby driver. Hayley takes Steve on a road trip, so he can learn to drive.

Francine helps Hayley take a break from their marriages. Stan and Jeff pretend to be frontiersmen.

The Smiths return from a difficult, quarrelsome vacation, but they can't get a break from one another.

Hayley and Jeff move into a van and start living life on the open road. Francine and Steve are haunted by an Uber driver that they rated poorly.

American Dad becomes the 25th scripted primetime show in the History of Television to reach 300 episodes and Roger's past comes back to haunt him.

Francine and Stan swap spouses with their gay neighbours Terry and Greg when Terry's dad, a former football player who doesn't know that his son is gay, arrives for a visit. Meanwhile, Steve goes on a drunken bender.

When Stan doesn't feel confident in anything but his suits, Roger assumes a fashion designer persona to craft him a life-changing new wardrobe. Hayley and Jeff raise chickens in the back yard.

Stan has Roger pretend to be a shark to help Steve overcome his fears. Hayley's friend Danuta becomes romantically interested in Klaus.

Stan insists everyone help him recreate the rustic family ski trips of his childhood while Klaus falls in love with a tech support operator.