Stan is ecstatic--and energetic--when a coworker gives him pills that allow him to stay up all night.

A mold of Francine's vagina is displayed in a museum.

Upset that Hayley no longer wants his advice, Stan decides to prove that she is missing out on his sage counseling. After meeting a stripper on an important CIA mission, Stan takes it upon himself to improve her life and show Hayley that his advice works. But when he opens a new business, hoping to prove Hayley wrong, he finds himself dancing for cash to cover up his failures.

An aspiring inventor leaves the Farm to make a go of it in The Big City.

When Stan enters an essay contest to have his personal hero, President Bush, come over for dinner, he is overcome with joy when the President arrives at his doorstep. However, not everyone in the Smith family shares Stan's excitement. Hayley tries to drill President Bush on the Iraq war, and Steve and Roger attempt to convince him that they've found Osama Bin Laden, but instead get him drunk. Stan tries to save the President from public humiliation, while Hayley revels in his fall from glory.

When Stan catches Steve playing imaginary games with his toys, he decides to take his son down to Mexico to help him become a man. But the trip takes a turn for the worse when Stan and Steve are kidnapped by a drug cartel, and it’s up to Steve to break himself and Stan out of captivity.

When Steve gives the family better Christmas gifts than Stan, Stan goes to great lengths to regain his title of "King of Presents."

When Stan tries to trick Steve into attending summer camp, things go horribly wrong and Steve ends up in a refugee camp. However, Stan, being the eternal optimist, joins Steve and manages to stage a camp Olympics between the refugees and the rebel faction living across the river.

Stan loses his confidence, and his job, when a car salesman gets the best of him in a negotiation. Meanwhile, Roger and Steve set up a makeshift drive-in to try to get to first base with popular schoolgirls.

It's Roger's 1600th birthday, but the Smiths are too freaked out by Steve's impending puberty to celebrate. So Roger decides to make his own birthday fun.

Roger declares that he was sent to Earth to be "the decider" of humanity's fate, and Stan challenges him on it.

Francine and Stan compare parenting skills after Stan creates a clone of Steve; Roger searches for the missing bride and groom.

Everyone is separated after the ship explodes: Stan and Francine lose their memories and resort to primitive living on an island; Hayley and Jeff are rescued by the Navy and Jeff decides to enlist; and Roger and Steve try to survive on a lifeboat in the middle of the ocean.

When Langley Falls bans trans fats, Stan and Steve become smugglers. Meanwhile, Klaus gets word that he has received an inheritance but can't collect it because the CIA has turned him into a fish.

A talk show reveals that Francine was the toddler who, famously, was rescued from a well by a firefighter; Francine makes a discovery when she falls down the well on the anniversary of her rescue; Stan and Roger come up with a business idea.

To have a chance with a girl, Steve and Snot must track down a keg of 4Loko.

As Stan continues to dominate the household, Francine finds herself idolizing a group of women who seem to have it all. She tries to impress them and even lies in order to gain acceptance into their group, until she realizes they aren't as perfect as they seem. Meanwhile, loyalties are tested when Stan gets a new best friend.

When Roger helps Steve see that his father isn't as smart as he always believed, the power-hungry pair set their sights on fame and fortune in New York City. It doesn't take long for Roger to lose everything on Wall Street, and Steve contemplates prostitution after Jon Stewart shoots down his comedy routine. Meanwhile, the rest of the family is certain that the two have just run away to the tree house, so when it explodes in a lightning storm, they are devastated, but console themselves with Steve's college fund.

After Stan punches a male meter maid during a disagreement over a parking ticket, a judge sentences him to two weeks of community service--as a meter maid. Meanwhile, Hayley poses in the nude for an art class, where one of the artists turns out to be Roger.

Roger is forced to confront himself after a series of accidents. Klaus and Jeff bond.

When Steve brings home a permission slip to take sex ed at school, Stan flips out and demands to teach it himself. However, after Stan unrealistically explains the birds and the bees to Steve, he gets into an accident that causes him to take matters into his own hands. Meanwhile, Roger becomes a bartender in hopes of making something of himself.

When Stan goes to Atlantic City for a bachelor party and is shunned by his so-called best friend, Roger steps in and becomes Stan's new sidekick. Their friendship goes to a whole new level, but when they return home and face Francine, Stan realizes that what happens in Atlantic City doesn't necessarily stay there. Meanwhile, Hayley and Steve team up to break up a good-looking couple.

After Stan discovers that Francine has a secret sex garden, he feels like their marriage may be crumbling. Looking to rekindle their romance, Francine asks for a divorce so that Stan can experience life as a bachelor again, and both learn a valuable lesson in love. Meanwhile, addicted to an energy drink, Steve finds himself panhandling in the streets to support his new habit.

Francine demands that Stan take the family on a vacation after she learns all of their previous vacations never actually happened: The CIA had planted artificial memories of the "vacations" in their brains so Stan could ditch them. Meanwhile, Roger wants to be a thespian.

After an argument between Stan and Francine breaks out, Stan suggests they go see a counselor, who hypnotizes Francine and reawakens her lifelong dream of being a comedian. Meanwhile, back in Langley Falls, Steve brings home a potential love interest for Klaus.