Willis must help a promising soccer player make a life-altering decision after he's seriously injured, and another patient's hesitation to share that she's transgender makes it difficult for the doctors to diagnose her severe abdominal pain.

On Halloween night, Willis, Noa and Elliott rush to the scene of a fire at a haunted theater, where Dr. Nolan and her boyfriend’s son are trapped,

Willis defies Campbell’s orders when he helps Mario and Heather perform a radical procedure on a maintenance worker stuck under a boiler that exploded. Also, Angus’ father, Dr. Desmond Leighton, tries to seize Power of Attorney over Mike, who is still in a coma, even though Mike granted that right to his brother, Angus.

Willis and Campbell are sent to a Russian submarine in U.S. waters to treat a sailor badly wounded during an explosion, and violent convicts injured during a prison riot descend upon Angels Memorial.

The new residents are introduced to the ER. A new doctor from the army who knows many advanced procedures is flown to a shark attack on the beach with Mike Leighton and Leighton falls 20 feet from the helicopter. Dr. Guthrie Jr. is promoted to the director of the ER in addition to the OR.

The doctors treat cult members who unwillingly survived a mass suicide attempt, and Mario decides to connect with his late father’s girlfriend.

Leanne defies Campbell's order and uses the hospital helicopter to reunite a family for the last time. Meanwhile, Willis and Loa use a cell phone app to communicate with an autistic young girl.

After pulling a double shift, Mario risks his own life when he follows Willis to a construction site where two brothers are trapped on a crane 300 feet above the ground.

The ER is quarantined when a viral outbreak jeopardizes the lives of the doctors and patients at Angels Memorial. Also, Ariel, the young girl Leanne bonded with a year ago when she lost her father, returns to Angels.

Malaya must inform a college student who regains consciousness at Angels Memorial that she's the victim of a rape. Meanwhile, Willis and Campbell butt heads over a terminally ill woman who wants to end her life on her own terms; and a comedian is treated after he collapses on stage during a performance.

Guthrie becomes the hospital's new chaplain and considers undergoing a risky surgery to treat his Parkinson's. Meanwhile, the doctors treat patients involved in an apartment fire.

Christa saves a woman's life and then pleads with Neal to perform a surgery that will save the patient's reproductive future. Meanwhile, Mario gets into a fight with a patient after he delivers a diagnosis that could end the man's hockey career.

Christa is feeling insecure after Neal's former girlfriend makes a return to the hospital after a year of volunteering in Haiti.

Christa has to try and ignore her personal feelings as she and Grace attempt to help a patient who says he was abused at a camp for troubled teenagers.

The doctors work with the Center for Disease Control and Prevention to find an antidote to the deadly viral outbreak at Angels Memorial. Also, Leanne makes a life-changing decision, and Jesse welcomes a new batch of residents.

Four new first-year residents are immediately put to work by the ER's tough-minded residency director Dr. Leanne Rorish.

Angus utilizes his background in psychology when a woman cannot remember how she injured herself and others; Christa bonds with the mother of a patient with cystic fibrosis.

Christa must handle all emergencies at Angels Memorial that happen outside the emergency room; Malaya arranges a bone marrow drive for Carla; Leanne turns down a date.

Mario joins Rox and Willis on the scene of a boat crash and, in Center Stage, Leanne works to save a brother and sister who drank boiling water through a straw as part of a challenge. Also, Max's father tells Leanne to keep Ariel away from his son after he finds them kissing.

Elliot fears the worst after hearing the emotional testimony by Detective Gomez's wife at his malpractice trial, but he hopes footage Diego shot for his documentary will change her mind. Also, Rox attempts to connect with Willis but he pushes her away, and Leanne attempts to comfort Ariel in the wake of a devastating loss.

The Angels Memorial doctors treat victims caught in a landslide, and a group of children come in from a camping trip with measles putting the entire ER at risk.

Rox decides to make amends with her former step coach when she arrives to Angels Memorial with the local high school step team after a pyramid stunt goes wrong. Also, Noa pleads with Leanne and Campbell to try any other method before performing an emergency hysterectomy on a young teenage girl, who is experiencing complications after giving birth.

A new surgical attending Cole Guthrie joins Angels Memorial with the help of his estranged father and clashes with Leanne over their contrasting approaches to medicine. Christa has a crisis of confidence in the middle of a procedure on her first infant since the loss of her son.

Mario confronts Angus about his Adderall abuse and Christa is surprised to learn how romantically involved Neal and Grace were before she left for Haiti. Also, Dr. Mark Taylor returns to help Leanne find the money in their budget to keep Jesse and the nurses from walking out.

A 13-year-old girl arrives at Angels Memorial following a seizure caused by spina bifida and the doctors are shocked to learn she is Campbell's daughter. Meanwhile, a workaholic deaf patient and her translator are treated after their car rolls into the Los Angeles River.