Sean and Beverly Lincoln are a happily married English couple who are also the creators of a hit British TV show. Their life seems complete... that is, until a hugely powerful and charismatic US television network president persuades them to move to Los Angeles and recreate their show for American television. Things begin to unravel as soon as Sean and Beverly arrive in L.A. It soon becomes clear that the network executive has never even seen their show. To make matters worse, he insists that they replace their brilliant lead actor, an erudite Royal Shakespeare veteran with... Matt LeBlanc!

Sean and Beverly are still reeling from the network's decision to cast Matt LeBlanc as the star of their show. But when they meet him at a swanky L.A. dinner party at Merc's house, Matt couldn't be more charming or flattering about their show. Unfortunately, over time the natural animosity between Matt and Beverly rises to the surface, and Beverly learns just how much you don't want the former Friend as an enemy.

Beverly can't stand Matt, and the feeling is mutual. As a result Sean and Matt end up spending more time together, including an extended adventure in Las Vegas. Soon the two guys have bonded, leaving Beverly feeling excluded by her husband's new bromance.

Sean and Beverly end up on all-night road trip with Matt when they pick him up from a bar.

Sean's infatuation with the lovely "Pucks!" actress Morning Randolph is given an opportunity to blossom when Matt invites the two of them to a charity benefit. Sean realizes that his attraction to her may be, in fact, mutual. Meanwhile, Beverly and Carol share a joint and commiserate about the men in their lives.

The ratings for "Pucks!" are plummeting. The network asks Sean and Beverly to reduce Matt's role in the show to make way for his teenage co-stars - the increasingly popular "Pucks!" boys. This enrages Matt, who gets drunk and is ready to take some rash actions, but Beverly asks him to reconsider.

Sean and Beverly's marriage has been ripped apart by Beverly's fling with Matt. And Matt's friendship with Sean appears to be beyond salvage. But as their sitcom "Pucks!" premieres in the U.S., the three are forced to find a way to continue working together.

Matt continues to fight with his ex-wife for custody of his children. Sean and Beverly are back together, but they soon discover that it's not so easy to heal old wounds. Meanwhile, Carol's ambitions at the network are dealt a cruel blow.

Matt's custody battle for his kids gets more difficult after he gets a DUI with them in the car. Sean struggles with the news that Beverly spent a night with ruggedly handsome Rob. Carol, once again, falls under the spell of her charismatic new boss.

Matt's career takes an unexpected turn when he appears on The Tonight Show with Jay Leno. Merc comes in to pitch new shows to Carol. Oh, and there's a devastating earthquake in Peru.

Beverly prepares to return to England, while Sean hangs onto hopes of keeping his Hollywood dream alive. Matt is crushed to learn that his former stalker is no longer obsessed with him. Carol is equally despondent when her dreams for a future with Castor are dashed.

Matt’s gameshow "The Box" is now a runaway hit. Unfortunately for Matt, success also means having a daily contact with his producer, Merc Lapidus. Meanwhile, Sean and Beverly are forced to work for Sean's loathsome ex-partner Tim, after Helen puts him in charge of their new show. And unable to find another job, Carol goes into a tailspin.

Matt leverages his newfound celebrity to get a new series guarantee from the network. Convinced that his best chance for success lies with Sean and Beverly, he tries to woo the reluctant Brits away from Tim. A large stuffed gorilla is involved. After weeks curled up on the sofa, Carol hits rock bottom - but finds solace in the most unlikely of places.

Convinced that Sean is having an affair with Morning, Beverly packs a bag and leaves, intending to head back to London. However, in her distress, she is unaware that she's driving on the left side of the road. Beverly doesn't realize her mistake until she has a head-on collision - a collision which leads her down a road with even more dire consequences.

Sean meets Labia, a super-fan of Matt's and Morning suffers a major plastic surgery disaster. Meanwhile, Merc and Carol plan a weekend getaway to Mexico, while Jamie and Matt pack for a tryst in Napa.

The network insists that Sean and Beverly confront Matt about his recent weight gain. The star does not take the news well. Meanwhile, Beverly agrees to go out to dinner with Morning's brother Rob, even though she insists that she is terrible at dating. She is not wrong, and she turns the evening into a date from hell.

Matt's life continues to fall apart when he falls foul of his fierce ex-wife. Beverly prepares to go on a second date with Morning's brother Rob, but things have become much more complicated now that Sean is aware that she is seeing someone.

Bev and Sean are still struggling with their relationship. Castor Sotto is getting more and more out of hand and wants to cancel the show. Carol convinces him to give it another chance and they get a new time slot. Andrew gives Matt a pilot script that turns out to be amazing and he wants to be a part of it.

Matt has to sell his beach house - or take a job as a game show host.

Back on the hiking trail for the first time in months, Carol confesses to Beverly her newfound happiness with Merc. Appalled, Beverly nevertheless agrees to support her - until she discovers that Merc has recently become engaged. To Morning Randolph! Matt takes Sean and Beverly to his ranch for a working weekend to try and come up with a new series. Gunplay ensues. And a wild boar.

Sean and Beverly find themselves in an ugly dispute with Matt when he demands a writing credit on their new show. Neither side is willing to give in. After all, they came up with the premise - but he bought the pads and pens! Carol decides to leave television, move home to Michigan and raise the child on her own. However, before doing that, she sues Helen and the network for sexual harassment.

The filming of 'Pucks!' draws to a close and everyone is focused on what they will do next. Bev gives Carol an ultimatum when she reads the script and wants to turn it into a show. NBC wants Matt to audition for the role in Andrew's pilot, but Matt is unwilling to do so. To make matters worse, Matt becomes a target of a rumor that might jeopardize his opportunity at landing the role.

Matt tries to solve his financial troubles; networks compete for Sean and Beverly's new show; Carol must make amends to a woman she scorned.

Carol attempts to slow down the pace of her new relationship with Helen. Meanwhile, despite Beverly's objections, Sean gets Matt to read the script of their new show. Things take an unexpected turn when excited Matt wants to play one of the roles in it, and Sean and Beverly aren't exactly thrilled about it.

Matt misses his "bromance" with Sean and tries to rekindle their friendship by buying him the sports car of his dreams. But Sean is not willing to forgive or forget that easily.