After he is summoned unknowingly by Ben Pitcher to treat one of his cows, a human patient of Doc's dies. During a fight with Pitcher, Doc is knifed.

After his friend Ben Williams is shot down by Lou Shippen, Matt travels to Elkader to bring him him. The only problem, he doesn't know what he looks like and the town is protecting Shippen.

Matt refuses to turn the rustler Joe Trimble over to Major Banker for court-martial.

Matt closes up shops to a group of drunken cowboys, which causes trouble.

After gunman, Sam Kercher is killed by Matt, his 16-year-old brother arrives to fight Matt.

At Fort Dodge, home of the third cavalry, Mrs. Mary Cullen tells the colonel that the twelve year old white boy they recovered from the Cheyenne is her son Dennis. The tribe had taken him when he was two years old.

Matt is used by an old friend in a con game.

Doc comes upon a homesteader with a busted leg—and a gun to protect himself from his wife.

Matt leaves Dodge City unprotected when he sets out to find a killer (Mike Connors) (Bert Rumsey credited as 'Bartender', but referred to by Chester as 'Sam Noonan').

An outlaw threatens to kill Doc if he does not help his wounded buddy.

Matt and Chester act as decoys to ambush outlaws (including Mickey Simpson) that are masking their crimes as those of renegade Indians (Fintan Meyler and Herbert Rudley appear).

Matt discovers that he was the intended victim of a murder he is investigating.

Matt helps a woman whose suitors are about to duel for her affections.

A landowner (Paul Fix) tries to terrorize homesteaders (Bartlett Robinson and Peg Hillias) off their land (Gordon Gebert, John Smith, and Stuart Whitman appear).

An old buffalo hunter (Edgar Stehli) swears revenge on the skinner (Grant Withers) that left him to die (Richard Deacon appears as banker Botkin, Bert Rumsey credited as 'Bartender').

Matt traps a cattleman (Tyler McVey) who shot two homesteaders (including Roy Engel) (Malcolm Atterbury and Vivi Janiss appear).

An Indian woman (Angie Dickinson) faces prejudice for her father's raid on Dodge City (Peter Whitney and Paul Wexler appear).

A bank robber (Robert H. Harris) murders his wife and frames Tobeel (Frank de Kova) for the crime (Paul Lambert appears).

A young gunfighter, Tom Clegg, forces farmer Abe Curry into a duel and kills him. Matt can't arrest Clegg since Abe drew first. However, Abe's brother Morgan plots revenge.

Townspeople protect an outlaw (Carl Betz) they believe has reformed (Tige Andrews, Joe De Santis, John Dierkes, Marianne Stewart, and Ward Wood appear).

The shooting of several members of an outlaw gang, though in self defense, triggers an emotional crisis in Matt, haunted by memories of all the men he has killed (Lawrence Dobkin, Russell Johnson, and Gloria Marshall appear).

An Eastern girl makes the long trip to Dodge, only to find that her fiancé has lost his money and won't marry her.

Rena Decker, a new dance hall girl, purposely gets her admirers into fighting over her. Despite Kitty's negative opinion of her, Matt befreinds Rena and gets her a job at the Long Branch. Soon afterward, 4 men are dead and Rena is the cause.

Ex-gunslinger Joel Adams' past is about to catch up with him.

A Washington official is determined to tame Dodge City.