Matt resigns as Marshall after Tom Samples accuses Matt of killing an innocent man;however, Doc and Matt's old friend Wild Bill Hickok come up with a plan that might clear Matt of this erroneous charge of murder.

Matt doubts the veracity of Long Branch hostess Holly Fanshaw's claim that she saw trail drover Fly Hoyt murder young Dave Thorp. His suspicions increase further when Hoyt voluntarily returns to Dodge in order to clear his name.

Matt believes white smugglers supplied the guns that a band of Pawnee used to attack local ranchers.

Two murders result when an unscrupulous Eastern businessman named Ivy hires a psychotic killer to help him establish undisputed control of Dodge City's freight shipment business.

A rich landowner seizes the chance to get a little more acreage when he discovers that a homesteader has failed to file the paperwork to make his quarter section his own.

Matt and Chester, out of water while riding back to Dodge, come upon a man with two fine horses who is not very trusting. When they meet him later in Dodge, he is much different: friendly and spending money freely.

A stagecoach on which Matt and Chester are riding is robbed and another passenger is murdered. Matt utilizes a ruse to incriminate the thieves when a "cowboy" appears and offers to show him where one of the thieves may be buried.

Matt refuses to arrest his friend Ben Tiple without more evidence, when the man he has been feuding with is found shot in the back.

When a stranger leading some immigrants planning on settling outside of Dodge wants Matt to give him a badge to avert trouble, Matt gets suspicious and rides out to their camp to see what is really up.

After mild-mannered Hank Blenis is "lynched" by the two men who stole his horse, self-righteous Charlie Drain decides to take the law into his own hands and is led tragically astray by the culprits.

Two gamblers find Matt incorruptible and attempt to intimidate him by hiring gunman Toque Morlan. The two are ironically unaware that Morlan was Matt's close friend until a long-ago attack by a mob left Morlan scarred and harboring a bitter grudge against lawmen.

White men pretending to be Indians attack greenhorn Harry Pope at night, and he kills one of them. Now the dead man's friends want revenge.

When Doc arrives too late to save his patient, her husband, a good friend of Matt's, blames Doc for her death.

Financially desperate Jack Fitch robs a stagecoach and abducts passenger Laura Church, unaware that she is "engaged" to an unscrupulous businessman who threatened to ruin her father if he did not agree to the marriage.

Claustrophobic plainsman Poney Thompson is arrested for murdering a man who maliciously shot his dog, but an ironic fate awaits him after he breaks free from Chester's custody.

Matt's attempt to find a man who shot at him from ambush leads him and Chester into the middle of a murderous feud between two bitter and isolated mountain families.

Over the objections of his sometime partner Rod Allison, treacherous Jim Box murders aging rancher Jesse Wheat, then attempts to steal cattle from Wheat's young widow.

Matt goes along with a hoax when Chester's aging Uncle Wesley arrives for a visit. Wesley thinks Chester is the marshal and Dillion is his assistant.

A man's house is burned and his livestock killed, but he refuses to identify the perpetrators to the marshal.

An old friend of Doc's, a nurse, is visiting and he hopes she will stay around Dodge. In the meantime Matt is worried that an ex-con is gunning for him even though he thought he was innocent five years ago.

Trail boss Dolph Quince sends for his friend Matt to help escort his cattle herd into Dodge because he is having trouble with Jayhawkers (Kansas renegades), and he hopes to ease the animosity his men have towards all Kansans.

An old friend of the family comes to Dodge looking for Kitty, but when he finds out she's a saloon owner, he's dismayed. Intent on defending her honor wherever she is insulted, he nearly gets himself killed. Kitty finally tells him that she has no honor, and he keeps making a fool out of himself thinking otherwise. It sends him away and saves his life at the same time.

Young Billy flees Dodge in fear after being suspected of shooting dead an older saloon girl whose sexual advances he had been resisting.

Doc takes hard the death of a homesteader under his care; then a flashy new medicine man comes to town and takes away many of his patients.

Rivalry for the affections of a former saloon gal leads to a frame-up for murder.