Haunted by past mistakes, Hamilton embarks on a journey to correct an error in his reporting and identifies the origin of an international toad venom smoking phenomenon.

Hamilton embarks on a quest to answer the most important question in ethnoherpetological history and along the way, he finds the power of love.

From the heavenly cloud forests of Oaxaca to a viral video of Miley Cyrus, Hamilton investigates the inconspicuous yet extraordinary psychedelic plant Salvia divinorum.

Hamilton travels across North America to study how and why DMT exists in the environment and the laboratory.

Hamilton meets an unsung hero of the psychedelic underground and hears a tragic tale of MDMA synthesis and chemiluminescence.

We meet with famed LSD chemist Casey Hardison in the Nevada desert and embark on a roadtrip to visit the unsung hero of psychedelic history.

South Africa is the last place on earth Quaaludes can still be found; Hamilton travels there to study the drug and learns of a dark history of medical experimentation.

From the greenhouses of Thai cactophiles to the Tamaulipan thornscrub, Hamilton traces the history of peyote with the help of a Native American peyotist.

Hamilton ascends the Carpathian Mountains, microscope in hand, to learn how Europeans use Amanita muscaria, and uncovers the chemistry behind a mushroom-inspired pharmaceutical.

Hamilton heads to India to see industrial Ketamine synthesis, and speak with therapists and luminaries in an attempt to understand the role of dissociative anesthetics in society.

Hamilton investigates the history of PCP in the U.S., seeking input from addicts, dealers and chemists.

Hamilton explores magic mushrooms with the help of shamans, clandestine growers, and ethnomycologists.

Deep in the Andean highlands of Peru, Hamilton becomes the apprentice of a local shaman, learning how to use the night-blooming San Pedro cactus as a medicine.

From X-ray crystallography to vesicular dopamine release, Hamilton travels the country visiting meth labs in order to understand the process behind a great American folk art.

With the precise structure of LSD's molecular target identified, Hamilton discusses the new era of psychedelic research and meets pioneers of the field.

Hamilton investigates the pharmacology and traditional uses of Kratom, a Thai tree with opioid-containing leaves.

Hamilton traces the multibillion year history of nitrous oxide on Earth and follows the strangest noble gas to the Czech Republic.

After revealing a scientific mystery around Tramadol-addicted cows in Central Africa, Hamilton follows a Gabonese opiate addict to a psychedelic ritual.

Hamilton embarks on an aquatic adventure to Reunion Island and Madagascar to investigate ichthyoallyeinotoxism and a twisted history of hallucinogenic fish.

Succumbing to viewer requests, Hamilton journeys to South America to understand the legend of Bufotenine, the world's oldest psychedelic.