From the heavenly cloud forests of Oaxaca to a viral video of Miley Cyrus, Hamilton investigates the inconspicuous yet extraordinary psychedelic plant Salvia divinorum.

We meet with famed LSD chemist Casey Hardison in the Nevada desert and embark on a roadtrip to visit the unsung hero of psychedelic history.

South Africa is the last place on earth Quaaludes can still be found; Hamilton travels there to study the drug and learns of a dark history of medical experimentation.

Hamilton investigates the history of PCP in the U.S., seeking input from addicts, dealers and chemists.

Hamilton explores magic mushrooms with the help of shamans, clandestine growers, and ethnomycologists.

Hamilton embarks on an aquatic adventure to Reunion Island and Madagascar to investigate ichthyoallyeinotoxism and a twisted history of hallucinogenic fish.