Haunted by past mistakes, Hamilton embarks on a journey to correct an error in his reporting and identifies the origin of an international toad venom smoking phenomenon.

From X-ray crystallography to vesicular dopamine release, Hamilton travels the country visiting meth labs in order to understand the process behind a great American folk art.

With the precise structure of LSD's molecular target identified, Hamilton discusses the new era of psychedelic research and meets pioneers of the field.

Hamilton traces the multibillion year history of nitrous oxide on Earth and follows the strangest noble gas to the Czech Republic.

After revealing a scientific mystery around Tramadol-addicted cows in Central Africa, Hamilton follows a Gabonese opiate addict to a psychedelic ritual.

Succumbing to viewer requests, Hamilton journeys to South America to understand the legend of Bufotenine, the world's oldest psychedelic.