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Jess and Zubin talk and Sean realises she does not love him, so they decide to end their relationship and call off the wedding. Meanwhile, Chrissie persuades Connie to consider Mark for a permanent position, and she says she will interview him that afternoon. Mark says he will go but he later changes his mind and tells Connie he does not want the job. Connie is furious and berates Chrissie. Chrissie storms into the bar where Lisa and Mark are drinking and tells Mark she wants nothing more to do with him. Dominic Fryer starts work as the new teaching consultant but Diane is shocked to see him. One of his students, Emma, turns up, and they argue and she attacks him. Dominic collapses and discovers he has a hernia, so Ric agrees to operate on him later. Diane questions Emma on her relationship with Dominic. She asks if he forced himself on Emma and reveals he did the same to her. Dominic says he wants to be awake during his operation. During the procedure, Dominic and Diane start to argue

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Zosia manages to overstep the mark and accuses a patient of a media leak forcing Oliver to deal with an unwelcome dilemma. Zosia comes to a gut-wrenching decision as Serena discovers Bernie is working on AAU, Dominic has to face his fears.

With Evie still recovering from her fall, Fletch commits to being a better dad.

Sacha's birthday celebrations don't go quite according to plan.

On Josh’s birthday, a surprise celebration causes him to fall back into dangerous habits. Kylie tries a bold strategy to save Lucky, and Russ and Hanssen find themselves locked in a store cupboard together.

As the reverberations of Jac’s surgery impact around Darwin and beyond, will life on Wyvern Wing ever be the same again? Series Finale

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Lucky asks Max for an impossible favour. Hanssen reluctantly agrees to mentor a new protege, despite their shared and painful history. Will Ange notice that Josh isn’t handling the pressure before it is too late?

Mike Barratt considers a transfer to a hospital in New Zealand, to get away from the frustrations of the constraints on his work at Holby. New ward sister Chrissie Williams arrives, and gets off on the wrong foot by being rude to Jasmine Hopkins. One of Stan Ashleigh's schemes accidentally causes a widespread power cut in the hospital, interrupting operations, and trapping Anton Meyer in a service lift with James Campbell, who is becoming increasingly distraught over the death of his daughter, for which he holds the hospital staff responsible, despite Meyer's assurances and the conclusions of the in-house investigation. Victoria Merrick's murderer is identified.

Terry Fox proposes to Kath Shaughnessy, But changes his mind once Ric Griffin tells him he has terminal cancer. Marty Campbell-Gore comes back to Holby, which leads to a revelation for Tom, his brother. Bob Butler is admitted to Darwin Ward for a leg artery by-pass operation, but things turn out even worse than he and his wife feared. In Maternity, Mary Jenkins has triplets by Caesarian, but a serious problem with one of them is discovered soon after birth. A teenager who is sick of her mothers drug-dabbling antics, wants to be put into care after her mother is admitted with a dangerous reaction to an ecstacy tablet, which was supplied by Tom Campbell-Gore's dodgy brother Marty.

Alex Adams feels more deppressed about his Parkinsons when he attends his father's funeral and meets his estranged family.

Sahira defies Hanssen in an attempt to save the cardiac trauma unit and Darwin.