In the surgical department of Holby City Hospital, surgeons Anton Meyer and Nick Jordan race against time to carry out a heart transplant operation, but first they have to make the difficult choice between two possible recipients, Alan Kenyon and Simon Harwood. Nurses Julie Fitzjohn and Jasmine Hopkins vie for the post of Deputy Ward Sister.

Nick Jordan is put to the test when he is the only cardio-thoracic surgeon available to perform an urgent operation. Jasmine Hopkins has to use all of her diplomatic skills to remake a good working relationship with Julie Fitzjohn. There is a tough new ward sister, Karen Newburn, for everyone to contend with; it appears she and Nick Jordan have a ‘history'.

Kirstie Collins, who is helping Muriel McKendrick with the trial of a new drug, finds a severe adverse reaction from a patient, and wants to alert the drugs company, but McKendrick warns her against doing so. The staff of Darwin Ward, the cardiology ward, struggle to stop the spread of the life-threatening MRSA infection; suspicion about its origin falls on Nurse Julie Fitzjohn. There's gossip about Nick Jordan and Karen Newburn.

Kirstie Collins catches Nick Jordan in a compromising situation with Ellie Sharpe in a linen cupboard. Nicola Fallon, the girl in a coma, reaches crisis point, and her parents face an agonising decision.

Nick Jordan has to assist Anton Meyer on a heart operation on a new-born baby, but he expresses his reservations to him. Julie Fitzjohn helps a young mother with a heart-breaking dilemma. Meanwhile, the pressure is building on house officer Victoria Merrick, after she saves the life of a patient, Chris Woodhouse, and she resorts to taking drugs at work.

Nick Jordan helps a family to make a difficult decision, but he can't escape a clash with Karen Newburn over their troubled past, as well as an altercation with an ex-boyfriend of Ellie Sharpe's. Anton Meyer and Muriel McKendick are still clashing over the allocation of beds.

The treatment of a young woman, Christine, causes conflict between Anton Meyer and Muriel McKendrick. Nick Jordan is put in charge of a delicate heart operation by Meyer, and has to ask Kirstie Collins to assist, even though it means her missing an exam.

Sunny Sunderland enters a radio phone-in competition, winning a large sum of money - for charity. Victoria Merrick risks throwing away her medical career by continuing taking drugs. Muriel McKendrick finds the ideal recipient for her latest breakthrough in medical procedures - unfortunately, the patient is a former colleague, who passes on some revealing insights into McKenrick's past to Kirstie Collins, much to Collins's delight. Two visiting friends of a young patient, Darren Ingram, deliberately disturb his medical equipment, with near fatal results. When they steal some drugs, they are chased by Jasmine Hopkins, and they stab her in order to escape.

Jasmine Hopkins is operated on by Nick Jordan, but hovers between life and death; it's discovered she's in the early stages of pregnancy. Ray Sykes and Sunny Sunderland find out about cash-strapped Julie Fitzjohn's double life working in a night club. Karen Newburn reprimands her about it, and offers her Hopkins's post temporarily, which she accepts, giving up the other job.

A serious road accident involving a motorbike cuts short the bus journey to work for Jasmine Hopkins & Julie Fitzjohn. Meanwhile, back at Holby City, new cardio-thoracic surgeon Alex Adams and new junior nurse Sandy Harper are immersed in a struggle to cope with the chaos caused by an infection scare.

Victoria Merrick is thrown into the deep end in pediatrics. Jasmine Hopkins's traumatic past helps her care for a patient who's convinced she has ovarian cancer.

When a well-known hospital fundraiser, John Wooldridge, demands a risky operation, Mike Barratt has to decide whether to refuse, or bow to management pressure.

The pressure is mounting for Julie as her trial period as ward sister comes to an end. Difficult patients, incompetent staff and domestic problems all contribute to making this a day from hell. Meanwhile, Steve is proved right when an apparently straightforward case turns out to be something far more sinister.

Sandy makes a play for Adams at the hospital party. Kirstie takes hospital rules into her own hands when she gives an elderly patient an unlicensed drug.

Keri befriends a teenage runaway with a guilty secret. Kirstie performs a dangerous emergency rescue. Victoria teaches a difficult patient a lesson.

Jasmine's involvement with a patient causes a stir on the ward. Mike has to make a difficult decision. Romance is in the air as Sandy plays Cupid.

Meyer faces his greatest challenge when his surgical career is threatened by illness. Is he capable of operating on eminent surgeon and former teacher Ian Richards? Julie is forced to reassess her priorities when her daughter, Rosie, is taken seriously ill.

With her daughter's life in jeopardy, Julie believes that only Meyer can save her. But is Meyer up to the challenge? Stan and Danny set about putting on a show for the children in Otter ward.

Tensions run high on Otter Ward when a major road traffic accident brings tragedy to one family as they face up to the death of their son, and joy to another as they are told that their daughter can have a long-awaited heart transplant. Meanwhile, Dr Taylor gets tough with Keri.

Janice Taylor finds herself at the centre of a legal battle when a teenage girl refuses life-saving treatment. Kath attempts to reconcile an estranged couple.

Tash faces a professional crisis when a patient fails to come round after an operation. Steve and Jasmine confront danger as they hunt for a missing boy. Dr Taylor clashes with an over-protective mother. Keri has to deal with an unexpected visitor to the ward.

Mike's day gets off to a bad start when a politician dies during a routine operation - and when a newspaper reporter gets hold of the story, things go from bad to worse. Alex solves a riddle with welcome consequences for a new mother.

Its a tricky night for the otter ward staff when a young nurse takes it apon herself to take part in a round of the ward with possible tragic concequences. Victoria manages the situation and gets her first ""well done "" from her boss Janice Talyor.

Janice Taylor becomes emotionally involved with a young patient when he demands more than medical help after his mother dies. Victoria Merrick jumps to conclusions when she treats a young teenage girl with amnesia and bruising.

An ex-alcoholic is admitted with a bleeding oesophagus: his wife suspects that he's been drinking again, but is it fair to jump to conclusions? Meanwhile, the staff of Darwin Ward celebrate too hard in advance of Liam Evans's wedding, which does not go according to plan.