Nick Jordan helps a family to make a difficult decision, but he can't escape a clash with Karen Newburn over their troubled past, as well as an altercation with an ex-boyfriend of Ellie Sharpe's. Anton Meyer and Muriel McKendick are still clashing over the allocation of beds.

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Janice Taylor becomes emotionally involved with a young patient when he demands more than medical help after his mother dies. Victoria Merrick jumps to conclusions when she treats a young teenage girl with amnesia and bruising.

An ex-alcoholic is admitted with a bleeding oesophagus: his wife suspects that he's been drinking again, but is it fair to jump to conclusions? Meanwhile, the staff of Darwin Ward celebrate too hard in advance of Liam Evans's wedding, which does not go according to plan.

When Julie Fitzjohn adopts the role of mediator in an effort to reconcile a dying man with his estranged son, she is soon forced to reflect on her own situation.

Anton Meyer is seriously injured in a road-rage incident and is brought to Holby for an emergency operation. Mike Barratt's replacement Ric Griffin arrives. Alex Adams plays detective when he realises that the wife of an apparent road injury victim admitted at the same time is driving around in Meyer's car.

Anton Meyer proves not to be the ideal patient and his recovery suffers a minor setback. Alex Adams and Alistair Taylor have a clash of personalities. Keri McGrath finds herself in a compromising position with Liam Evans after Sandy Harper's 20th birthday party.

Janice Taylor holds a dinner party to welcome Anton Meyer back to work, his first case badk is a heart transplant patient who has been poorly treated by the system. Janice discovers she is now pregnant to to the latest round of IVF. Alex Adams is jealous when he finds Samantha Kenedy and Ric Griffin together. Word begins to spread about Keri McGrath and Liam Evans.

Keri McGrath's rape is investigated by a tribunal. Darwin Ward is troubled by a manic depressive heart patient. Marjica Ovcar has to bring Luka back for an emergency treatment, even though she cannot pay for the treatment she has already.

Janice Taylor wants to proceed with another round of IVF treatment immediately, but Alistair is not so sure. Chrissie Williams offers him a shoulder to cry on over a drink, but it leads to somewhat more. Samantha Kennedy gets badly involved with an anorexic heart patient and her over-protective mother. Janice has to tell Danny Shaughnessy not to take too much pity on a struggling single mother, but he is also becoming increasingly involved with Marija's attempt to evade the authorities.

Danny Shaughnessy goes ahead with his wedding to Marija Ovcar, despite his mother Kath being sure it's a big mistake. Sandy Harper wangles herself the role of bridesmaid. Meanwhile, a young patient of Keri McGrath's is discovered to have had a recurrence of her cancer, while her parents argue because of their different views on religion. A woman comes into Darwin Ward with apparent appendicitis, that under surgery is found to be an infection caused by a swab left behind after a previous operation.

Just before Christmas on Keller Ward, David Thomas, a young rugby player is brought in having sustained a bad leg fracture. Sandy Harper takes a fancy to him and stays late to decorate his bedside with extra tinsel. He dies during the night from complications from an unsuspected head injury. Chrissie Williams has to tell Alistair Taylor repeatedly that their affair is over. Janice Taylor finds out that she is pregnant again, but finds Chrissie's badge under the marital bed and sees husband Alistair behaving suspiciously with Chrissie. She confronts him, but he denies it sufficiently convincingly.

On New Year's Eve, Sophie, an ex-girlfriend of Alex Adams, arrives at Holby City, bringing with her a daughter he was completely unaware of. A strong-willed 77-year old, Annie Hackett, coerces Ric Griffin into doing an operation to remove part of her colon, against his advice. Simon Shaughnessy gets very drunk while still on duty, and has to be escorted off the premises by his family. Kath Shaughnessy's suspicions about Chrissie Williams and Alistair Taylor are as good as confirmed. Alex arranges to spend the evening with Samantha Kennedy, and she surreptitiously plies him with more drinks than he was wanting. He leaves temporarily to finish discussions with Sophie, but is then pressured into attending a road traffic accident. While driving back to rejoin Samantha, a child runs out in front of his car too late for him to avoid. He is then given a routine breathalyser on the spot.

Jamie, the child that Alex Adams knocked down, is starting to recover in Otter Ward when he suddenly worsens, needing an urgent operation, but dies in theatre. Blood tests confirm the positive breathalyser, and Alex is charged with drink-driving. Samantha Kennedy becomes increasingly remorseful that she was the one at fault, but still can't bring herself to confess to him or anyone. Dr Gupta's wife gives birth by Caesarian to their fourth child, and first son, in the Holby maternity unit, but almost at the cost of her life. Alistair Taylor prepares to leave his wife for Chrissie Williams, though she continues to consistently reject him. He and Owen Davis end up brawling in the car park, after Owen intervenes to stop Alistair hassling Chrissie. Janice sees them, and finally realises what has been happening.

Ric's Daughter shows up at Holby to ask for money and makes a date with Liam in the meantime, however he promptly cancells on her when he finds out whose daughter she is.

As Owen Davis discovers that his ex-wife is taking his daughter away to live in Sydney, Danny tries to persuade his mother to leave his father.

As Lisa breaks up with Mubbs, Alex prepare for his trial.

As Alex goes to court, Sam still hasn't told him that she was responsible.

Samantha Kennedy vows that she's off men for ever. A young woman with learning difficulties, Chloe Edwards, is in the maternity ward for complications with her pregnancy, and her mother is concerned. Stan Ashleigh's wife collapses in the hospital car park while delivering him to work, and she is admitted to one of the wards for tests and treatment.

Ben invites his parents to dinner with the intention of telling them that he is a homosexual.

Ric Griffin's day goes from bad to worse when Samantha accidentally bumps into his car in the car park and his daughter shows up again asking for more money. He says no and makes her get a job as Owen's new PA.