The new assistant administrator Ann Anderson arrives at Kensington General Hospital and is taken aback by the eccentricities of her staff.

Charley refuses to treat his old high school teacher.

Charley finds himself entertaining two different dates in the same restaurant.

Charley and Norman both face crises of confidence.

Charley becomes jealous when Ann is attracted to a famous doctor visiting the hospital.

Charlie, Ann, Norman, Amos, and Mrs Phipps are trapped in the cafeteria when a seven-year-old accidentally exposes them to smallpox.

Charley must perform surgery on a convicted mobster.

The new hospital administrator forces Amos to retire.

The staff try to catch a thief and a mysterious unidentified doctor.

Charley causes unrest among the nurses when he is laid up with a bad back.

A con woman tries to extort money from the hospital by faking an accident.

Amos's clumsy granddaughter tries to prove herself capable of carrying on the Wetherby medical tradition.

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Charley goes to jail for refusing to divulge a patient's medical history to a senator.

A new female doctor causes trouble for everyone.

A mugger is loose in the hospital.

Ann defends a nurse about to be fired for posing nude in a men's magazine.

The staff mount a Chrismas show to entertain the patients.

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A madman plants a bomb in the hospital.

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Charley fakes an operation to prevent Mr. Peckler from interfering with procedures.