House and his team must diagnose a Jewish bride who is taken ill at her wedding. However, House is more interested in analyzing Wilson's relationship with his new girlfriend.

House and the team take on the case of an avid blogger admitted with sudden bruising and bleeding. From her hospital bed, the patient blogs about her symptoms, doctors and prospective diagnoses to her dedicated band of followers and solicits their advice on a course of treatment. Such openness leads the team to contemplate the value of privacy, especially after House and Wilson uncover secrets from one another 's past. Meanwhile, Chase is coaxed into testing out the dating scene.

The team takes on the case of a high school senior who inexplicably blacks out during a class field trip. While in the hospital, the patient repeatedly hallucinates. After exhausting myriad ineffective treatments for her mysterious ailments, House attempts one last controversial approach to diagnosing her: monitoring her cognitive patterns and looking for clues. Meanwhile, Taub airs his dirty laundry at work, and Wilson attempts to furnish his condo.

House and the team take on the case of Sir William, a "knight" in a closed-off community of men and women living according to the ideals of the High Renaissance. As the team searches the medieval village for environmental factors contributing to Sir William's rapidly deteriorating health, Thirteen and Sir William debate the acts that define honor and loyalty, especially in regard to the "queen" of the community, one of Sir William's most frequent visitors. Meanwhile, Wilson starts over with an ex.

House's patient is willing to die in order to further his social cause.

While House's staff tries to diagnose a woman whose uncontrollable muscle flailing caused her to crash her car, House and Stacy try to resolve their relationship issues once and for all. Cameron refuses to take her HIV test, wary of the results.

A 16-year-old Hurricane Katrina victim suffering from hallucinations as a result of the tragedy is brought to House by his former bandmate who recently found out the girl is his daughter. Although House fears his friend is being scammed, he takes the case. As he works his way through the girl's lies so he can diagnose and treat her, he's forced to tell a few lies of his own.

When a runaway teen requires hospitalization, Adams butts heads with House when she insists they contact Social Services. Meanwhile, Taub has trouble forming a personal connection with his baby daughters and Foreman's relationship with a married woman comes out.

Dr. House and his team race to save a young man who may have not one, but two illnesses killing him.

Dr. House and his team race to diagnose a member of the mob and get him well enough to testify and enter the witness protection program while Cuddy works to convince Vogler of House's importance to the hospital.

Lies between a father and son may prevent House and his team from saving their patient.

A young mother has a seizure while bathing her newborn son and nearly drowns him. House and the team have two cases at one time as they try to save the infant and determine the cause of the mother's seizures.

House takes the case of a young girl who has been diagnosed with pancreatitis. When he takes her divorced parents to court to force them to allow treatment because they can't agree, the judge awards guardianship of the girl to Cuddy. Meanwhile, Tritter continues his strategy to force House to admit to his drug use by offering one of the team members a deal.

House and his staff must deal with a teenage Gypsy boy suffering from inexplicable respiratory distress. However, House has bigger issues on his mind: Cuddy has given away his handicapped spot.

The team takes on the case of an ailing groom-to-be who harbors undisclosed secrets from a previous relationship. As his fiancée tries to get answers to her many questions, a frustrated team winnows down the possibilities. Meanwhile, House spends extra-curricular time with his Princeton Plainsboro colleagues, performing a karaoke rendition of a Gladys Knight & The Pips classic with Foreman and Chase.

A teenage boy attempting to follow in his late father’s footsteps as an entertainer is admitted to Princeton Plainsboro with partial paralysis. As the team searches for a bone marrow match, they uncover a disturbing family secret. Meanwhile, House looks for creative ways to remove his ankle monitor so that he can attend a boxing match in Atlantic City, and he treats a patient who is convinced he is suffering from diabetes. Also, Taub faces a tough decision when his ex-wife Rachel tells him that she wants to move across the country with their infant daughter.

A successful, independent blind man is struck down with a mysterious illness, just prior to him asking for his girlfriend's hand in marriage. Meanwhile, House has a family member visit to inform him of a life change. "Love Is Blind" is the fourteenth episode of season eight of House and the 169th overall. The episode debuted in Canada on Global on February 27, 2012, and aired three weeks later in the United States on Fox on March 19, 2012. The unusual three-week delay was a byproduct of the 2012 Daytona 500 rain delay of 30 hours.

The team treats an Army veteran charged with treason after he leaked classified information. But the patient's life is put at risk when he refuses treatment unless he and his brother are given information about their late father, a war veteran, which raises questions about loyalty to one's family and country. Meanwhile, Adams suspects House may be sick, so she recruits Wilson and the other team members to plan an intervention and investigate his illness.

House and the team take on the case of a young boy who has violent dreams of being choked, and then wakes up but still can't take in air. Meanwhile, Park is having intimate dreams involving co-workers, which causes the team to question whether or not there's significance to what each of them dreams. Dominika discovers House has been keeping a secret from her and Wilson drops a bombshell on him.

Dr. House's diagnosis of a married woman with a rare sleep disorder forces her and her husband to examine their marriage and question their trust for each other.

House and his team have to act fast when a high school student is admitted with a mysterious and lethal poisoning, especially when they discover more teens have been diagnosed with the same deadly illness.

House's wheels start turning when a pro-cyclist admits to taking performance-enhancing drugs.

The team encounters logistical problems while trying to run tests on a 600-pound man due to his extremely large size. Meanwhile, House spends the night in jail after being arrested by Detective Tritter for various charges, including resisting arrest.

An 18-year-old teenager is brought to the hospital after having a heart attack. House reviews the boy's file and believes he has the diagnosis. He then turns the case into a game by sealing his opinion in an envelope and challenging Cameron, Foreman, and Chase to guess House's diagnosis on their own. Meanwhile, Tritter's actions against Wilson continue to strain the oncologist's relationship with House and destroy his ability to practice medicine.

The ex-marine that saved House's life, in a dream he had the day before, is admitted in the hospital with symptoms resembling Gulf War Syndrome. While House is busy dealing with his own health issues, and Chase and Cameron are too busy with each other, the ex-marine gets worse.