When Jesse s sister contacts him for help, he, Sarah and Rex head to Northern Ontario and find themselves in the middle of a deadly situation.

Detective Charlie Hudson teams up with what he calls his "highly trained law enforcement animal" German Shepherd dog named Rex who he prefers to team up with because he doesn't talk his ear off.

When two hikers are discovered murdered near a remote coastal trail, the team is on the hunt for a fugitive duo wanted in a series of grisly campsite murders.

The near poisoning of a wealthy socialite throws the team into a perilous investigation that puts Charlie, Rex, and even Jesse in harm's way.

Charlie and Rex are in grave danger as they find themselves captives of a kidnapper seeking vengeance.

Charlie and Rex witness an armed robbery during a trip to the bank; they discover a connection to a string of ingenious unsolved heists.

While Sarah embarks on a wilderness adventure, Charlie and Rex investigate the murder of a college professor.

After a truck transporting liquid explosive is hijacked by criminals, Charlie and Rex find themselves in a race against time to prevent the case from blowing sky high.

As Major Crimes investigates a dark web marketplace, Charlie and Rex protect a witness in their home.

The Major Crimes team is forced to turn against Jesse when he becomes the prime suspect in a bank robbery.

Charlie and Rex receive an award for heroism while Major Crimes investigates an extremist threat.

Charlie, Rex and Sarah travel to an isolated island community caught up in a resettlement dispute. Donovan tries to stop a British police officer from derailing the investigation.

While St. John's celebrates Mardi Gras, Charlie and Rex investigate a targeted killing spree.

When Officer Maya Power and her K9 partner Rebel are violently attacked responding to a call about a warehouse break-in, Major Crimes is at the ready.

When Rex is accused of attacking a decorated former police officer, Charlie enlists the help of an unorthodox ally to uncover the truth in the hopes of restoring Rex's position on the team.

When the co-owner of a successful board game company is found dead of a snake bite, the team has to not only catch the hugger but also the deadly venomous snake still on the loose.

When an important trial is jeopardized after Sarah s testimony is challenged by a former rival in court, it s up to Charlie, Rex, and the rest of the Major Crimes team to uncover new evidence to save the case before time runs out.

Charlie and Rex reveal a conspiracy within the parkour community, after a thrill-seeker falls to his death.

Charlie and Rex open up a cold case that may be connected to a recent case; Donovan asks Charlie to spy on his daughter.

When a controversial university professor is found dead in his classroom, Charlie and Rex investigate leads while Jesse goes undercover and soon finds himself in danger.

When the pharmacist at Charlie's aunt's retirement home is found dead, she alerts him to a mysterious string of recent fatalities among the home's residents.

Sarah finds herself in the middle of a hostage situation at a medical testing lab. When the team realizes there's no way inside without aggravating the gunman, Charlies sends Rex in to monitor the situation.

After a reviled restaurateur's food truck explodes, killing one of his employees, Charlie and Rex find themselves with a few too many suspects. A flirtation has Charlie torn between a possible new love interest and Rex, who makes no secret of his feelings on the matter.

With a gallery curator found murdered on his showroom floor and a missing sculpture, Charlie, Rex and Sarah are thrown into the world of high art. Jesse feels the burn when Sarah picks him as her new running buddy.

When an activist is killed during a break-and-enter at a water bottling plant, all evidence points towards his partner-in-crime, but Charlie and Rex aren't convinced.