When the sole witness against the son of a powerful mob boss goes missing in the woods, it's up to Mark, Rex and Jesse to track him down. The mob boss has already hired an assassin to find the witness.

A young lawyer is snatched off the street, but the team can't track her down until they locate the sole witness - a child who disappeared from the scene. Rex connects with the traumatized boy, who communicates primarily through drawing. The team races to uncover who is behind the kidnapping and at the centre of a money laundering scheme before the criminal rids themselves of their depreciating asset.

When a conspiracy theory podcaster is found murdered just before her talk at the TruthCon conference, Mark, Rex and the team find themselves thrown into the extreme world of conspiracy theorists. They find that one of the theorists is Mark's old commanding officer, now afflicted with PTSD. In the end, it's Rex's relationship with the old soldier that might lead them to the real killer.

When businessman Jake Kaufman is found dead on his yacht, all suspicion falls onto a deckhand who ran from the scene. As Mark and Rex search for motives and clues, it seems that the businessman's missing watch might be what the killer was after... But with Rex being unable to find traces of the watch on any of the suspects, the hunt for the elusive watch and the killer becomes a race against time to save another life.

An announcement on the future of the Devereaux Gin Distillery is cut short when the owner is found drowned in his own spirits. The three heirs to the family business become prime suspects as Rex sniffs out the secret ingredient behind a groundbreaking new gin recipe, while Mark revisits the night of the murder to put the family drama to rest.

When a survivalist competition broadcasts a finalist's body live on air, the team must figure out who was serious about burying their competition. Mark and Rex discover that the staged bear attack was actually murder, but the show must go on. Rex's keen hearing reveals a dead giveaway in the botched broadcast, leading the team to stage their own finale to catch the killer - live on TV.

After a man is stabbed by an intruder who left no trace of a break-in, Rex s senses reveal it was only a practice run for a scheme that goes much deeper.

Jesse and Stella's band gig goes sour when they become the victims of a mass poisoning, becoming key witnesses in piecing together a deadly night at the pub.

Donovan tracks a marine smuggling operation, the team investigates the night of a wedding to uncover why the best man ended up at the bottom of the Atlantic.

When the president of a beekeeping association is found stung to death, a foreboding note leads the team to investigate who was willing to kill to be the new queen bee.

Charlie and Rex are on the case after a social media star dies while live streaming her wedding.

When a murder appears to mimic an infamous crime spree from the past, Charlie and Rex rush to stop the culprit from continuing a serial killer´s legacy.

A K9-in-training leads her partner to a real crime scene, she uses her personal connection to the case to help Major Crimes bring justice to the victim s family.

After the confrontation between a murder writer and a victim's wife goes viral, the team reopens the seven-year-old cold case, uncovering new evidence.

The animal lovers of St John's are under suspicion as Charlie and Rex investigate the death of a professional pet sitter. At home, Charlie finds himself in need of Sarah's help.

A young woman is abducted from the very spot her friend was murdered two years earlier; Charlie and Rex race against time as they trail the suspects from the original investigation.

Jesse's friend vanishes; Charlie and Rex discover the man was living two separate lives.

When Supt. Donovan's journalism student daughter investigates the story behind a murder on her university campus, the team races to find the killer before someone else becomes the next victim.

Detective Charlie Hudson teams up with what he calls his "highly trained law enforcement animal" German Shepherd dog named Rex who he prefers to team up with because he doesn't talk his ear off.

After a reviled restaurateur's food truck explodes, killing one of his employees, Charlie and Rex find themselves with a few too many suspects. A flirtation has Charlie torn between a possible new love interest and Rex, who makes no secret of his feelings on the matter.

When a deadly car accident leads Charlie and Rex to investigate reports of a mysterious blue light in the sky, they discover the truth is more science than fiction.

Charlie lets Rex take the lead as they investigate a murder at a prestigious dog show.

When a troubled popstar is suspected of killing her fiancé, the team's investigation uncovers the distorted loyalties formed when personal ties meet the trappings of fame.

After an elite hockey prospect is found dead, Charlie and Jesse disagree over the prime suspect in the case.

After a raw diamond is found at the crime scene of a murder, Major Crimes sets up a stakeout to take down the suspected gem smugglers. An undisclosed team connection threatens to derail the investigation.