Goren and Eames find a scrapbook belonging to a serial killer on death row. It suggests that he may have had more victims than previously known.

The death of an eccentric banker in his nintieth floor apartment leads the detectives to investigate his professional contacts and family members.

Bobby is visited by the past when he finds a picture at his mother's grave indicating an old nemesis has returned, and the case only gets more complex when his brother and a mentor reappear.

The squad continues the investigation into the murder of a teenage girl visiting from Iowa. The detectives uncover the sordid family life of a local judge whose son is linked to the Iowa teenager and another victim. Goren and Logan discover that the judge is a formidable foe as they come under scrutiny.

As Goren and Eames sift through the likely suspects in the murder of a university president and his assistant, they discover that the culprit is a wily adversary who has more than these crimes to hide.

While probing the seemingly random murders of several homeless men, Goren and Eames uncover a scam involving a crooked insurance agent. However, an unsual twist leads the detectives to an unlikely suspect.

Goren and Eames investigate the murder of a former nurse and discover a possible anthrax terrorist plot. The case takes a turn for the worse when Goren is blamed for driving a suspect to commit suicide. Now disgraced, Goren learns that a cunning adversary from his past may be involved.

Detectives Eames, Goren, Barek, and Logan must solve a case that involves a teenage girl missing in New York City. While Barek and Logan search around for another missing girl, Eames and Goren work to uncover a mystery with a judge and his son.

Captain Danny Ross closely oversees Goren and Eames as they hunt for a possible serial killer. This difficult and harrowing case brings Goren back in touch with his old mentor, a profiler, and his mentor's daughter.

Eames re-opens the case into her husband's murder.

Logan jeopardizes his and Wheeler's careers when a priest convinces him to re-open a murder case that's over a decade old which involves a politically-aspiring ADA who will stop at nothing to keep the truth buried.

Captain Ross finds himself at the tragic center of an overseas conflict, galvanizing the assistance of Major Case detectives Goren, Eames and Nichols.

With an illegal arms deal and a hunt for Somali terrorists hanging in the balance, Detectives Goren, Eames, Nichols and newcomer Stevens combine resources in an attempt to bring justice.

The murder of a mortician and the discovery of corpses at a crematorium lead the detectives to a family man claiming to have a consulting business but suspected of being a contract killer with a penchant for perfection. Goren attempts to prove this by setting up a scheme that puts his "fear of making a mistake" in jeopardy.

After he gets into the head of an insane man driven to torture, murder, and cannibalism by overwhelming despair and loneliness, Goren surprises his colleagues with a passionate plea that the man be spared the death penalty, and engineers the confession that will save the man's life through a plea bargain.

When city health inspector Larry Chapel is found dead in an elevator, a quick look into Chapel's home life introduces them to Chapel's recently widowed brother, Evan, and little girl Gwen. Goren isn't very surprised to learn that Nicole Wallace is Evan's fiancée and the future mother to his little girl, but Major Case soon realizes they're off the mark in who they believe the suspect is, and Goren's only hope is to get Nicole to help him trap the killer. Logan joins the Major Case squad, but isn't pleased with being relegated to the background while the other detectives solve the cases, and Deakins tries to find a partner for him.

Logan and Barek investigate a series of home invasions that result in grisly murders and their search leads them to local foster mother Chesley Watkins who had a series of young men going in and out of her home throughout the years. One of the young men involved in the home invasions was one of her boys, and while trailing the young man, Logan shoots a suspect who was brandishing a weapon at himself and Barek. When the suspect turns out to be a cop, Logan finds himself in the hot seat, and Barek sticks up for her partner, knowing that the truth is on their side. The investigation leads to Watkins as a suspect, and Logan is forced to deal with memories from his own past as Watkins plays on the weaknesses she sees.

Goren investigates when his nephew, a prisoner who's bipolar, claims that inmates are being abused to the point of murder.

Still on leave from the force, approached in a bar after a confrontation, and pondering his future, Goren meets another officer on suspension (Winters) who makes him an interesting job offer. Goren decides to tip the balance in his favor with an undercover operation.

Detective Eames assists with Nichols' case involving the death of an addict who was just days from going straight when Wheeler is otherwise engaged in the labor and delivery of her baby.

When Goren and Eames search for a jewel thief who murdered her accomplice, they discover that the clever larcenies are the brainchild of her lover, Nicole Wallace, Goren's long-standing nemesis. As the detectives delve into the personal and working relationships between the two women, they uncover a plot to cause the death of Wallace's ex-husband, the only person who can lead them to evidence of the very first murder Wallace committed.

The detectives try to figure out a mystery after an old woman dies in a fire. The mystery gets deeper when a young woman who is left some of the old woman estate is killed. The case takes them to a state public administrator who has invented a form of grave-robbing. The detective suspects the administrator has a weakness for valuable cars, but to make his case work, he has to exploit his quarry's personal relationships.

When a bookkeeper goes missing, Goren and Eames are led back to the death of her brother, a hitman, two years earlier. An imprisoned mobster seems to be their best bet, but when another body turns up it takes the case to a whole new level.

When a prison guard is murdered, Eames and Goren investigate, only to discover they've riled the feathers of Mike Logan, a Staten Island police officer who happens to be dating the nurse at the prison. Logan joins the duo to find out exactly what is happening at the prison.

Logan and Wheeler investigate a firefighter's stabbing death, a crime that took place after the victim prevented a hate crime.