Goren and Eames investigate after a bridesmaid, Megan, is found dead in the cheap motel room she had been sharing with Alice, another bridesmaid at their friend Tory's wedding. The two detectives start with investigating Pete and Jayson, the two guys the women had met at Brasserie Nylorac, but soon realise that Alice's story has a lot of holes in it, and the presence of cigar smoke around Megan, a young woman who hated smoking, leads Goren and Eames to suspect that the killer had a personal connection to Megan. Their investigation soon leads them to a cab driver named Lester Summerhill, whom they soon realise is an actor preparing for the ultimate role.

The squad continues the investigation into the murder of a teenage girl visiting from Iowa. The detectives uncover the sordid family life of a local judge whose son is linked to the Iowa teenager and another victim. Goren and Logan discover that the judge is a formidable foe as they come under scrutiny.

Goren and Eames find a scrapbook belonging to a serial killer on death row. It suggests that he may have had more victims than previously known.

Detectives Eames, Goren, Barek, and Logan must solve a case that involves a teenage girl missing in New York City. While Barek and Logan search around for another missing girl, Eames and Goren work to uncover a mystery with a judge and his son.

After Russ Corbett and his wife are found in a seedy hotel room, Russ dead of an overdose, Eames and Goren follow the trail of evidence to Bernard Fremont, a professional partier. With his beautiful blonde companions, Fremont insinuates himself into the lives of couples who don't know the city very well, then robs them blind. While investigating Fremont's past in Asia, Goren realises that he is the mastermind that turned Nicole Wallace into a murderer, and his most successful pupil.

Goren and Eames investigate after Trip Slaughter III, the eldest son of radio magnate Jonas Slaughter, is found dead covered in plastic latex. Initial evidence leads detectives directly to Jonas' Chinese wife Anna, but Goren and Eames realise that the evidence leading her way is a little too pat.

Bobby is visited by the past when he finds a picture at his mother's grave indicating an old nemesis has returned, and the case only gets more complex when his brother and a mentor reappear.

As Goren and Eames sift through the likely suspects in the murder of a university president and his assistant, they discover that the culprit is a wily adversary who has more than these crimes to hide.

While probing the seemingly random murders of several homeless men, Goren and Eames uncover a scam involving a crooked insurance agent. However, an unsual twist leads the detectives to an unlikely suspect.

Goren and Eames investigate the murder of a former nurse and discover a possible anthrax terrorist plot. The case takes a turn for the worse when Goren is blamed for driving a suspect to commit suicide. Now disgraced, Goren learns that a cunning adversary from his past may be involved.

Captain Danny Ross closely oversees Goren and Eames as they hunt for a possible serial killer. This difficult and harrowing case brings Goren back in touch with his old mentor, a profiler, and his mentor's daughter.

Eames re-opens the case into her husband's murder.

Logan jeopardizes his and Wheeler's careers when a priest convinces him to re-open a murder case that's over a decade old which involves a politically-aspiring ADA who will stop at nothing to keep the truth buried.

Captain Ross finds himself at the tragic center of an overseas conflict, galvanizing the assistance of Major Case detectives Goren, Eames and Nichols.

With an illegal arms deal and a hunt for Somali terrorists hanging in the balance, Detectives Goren, Eames, Nichols and newcomer Stevens combine resources in an attempt to bring justice.

When the murder of a city auditor and his family seems too perfect, Goren and Eames turn their attention towards law enforcement personnel after learning that the auditor was investigating a number of former cops upon suspicion of double-dipping.

The murder of a mortician and the discovery of corpses at a crematorium lead the detectives to a family man claiming to have a consulting business but suspected of being a contract killer with a penchant for perfection. Goren attempts to prove this by setting up a scheme that puts his "fear of making a mistake" in jeopardy.

After he gets into the head of an insane man driven to torture, murder, and cannibalism by overwhelming despair and loneliness, Goren surprises his colleagues with a passionate plea that the man be spared the death penalty, and engineers the confession that will save the man's life through a plea bargain.

Goren investigates when his nephew, a prisoner who's bipolar, claims that inmates are being abused to the point of murder.

Still on leave from the force, approached in a bar after a confrontation, and pondering his future, Goren meets another officer on suspension (Winters) who makes him an interesting job offer. Goren decides to tip the balance in his favor with an undercover operation.

When an business executive's wife and two daughters are kidnapped for a loanshark because the loan hasn't been paid off, Goren and Eames are frustrated by the man's lack of cooperation, which stymies them further when the man's released daughter proves to have been sexually assaulted.

Detective Eames assists with Nichols' case involving the death of an addict who was just days from going straight when Wheeler is otherwise engaged in the labor and delivery of her baby.

Goren and Eames are called in when a jewelry heist leaves behind three bodies. After ruling out mafia involvement, they realise that the thefts are directly connected to recent credit card thefts and stolen identities. They're led to an extremely charismatic thief, and their only hope is convincing one of his partners to turn on him.

The detectives investigate a murderer who poisons hospital victims with cyanide. They suspect a nurse whose profile is typical, but when they discover more murders away from the hospital they have to widen their search.

The detectives investigate a slain bank robber and check out his sister, who is involved with a bogus United Nations economist. As the detectives close in on the suspect, Goren learns the suspect wants his children's approval and must stop him before any more murders.