Marc is riding high, his career is taking off and his relationship with Jen seems to be going well. However, Marc turns out to be his own worst enemy as he sabotages a TV guest spot and ruins his relationship at the same time.

Marc is annoyed that none of his old pals can hang anymore on a regular basis. Although after bonding with Ray Romano, Marc pursues a friendship, ignoring Kyle's warnings that Romano is on a different level.

Marc and Jen enter couples therapy with married therapists but instead of helping, it exacerbates their issues. After Marc feels wronged by the therapists, he ends up putting a dent in their "perfect" relationship.

Marc's mom comes to visit. He wants to avoid her and pawns her off on a friend's Dad. The plan backfires when the older couple hit it off too well and Marc has to parent his Mom through an STD scare.

Marc is dealing with the finality of his relationship with Jen but is sidetracked by his missing cat, Boomer. He goes door to door through his neighborhood, looking for his cat, while at the same time learning how his neighbors deal with loss.

Newly single Marc tries to start a no-strings sexual relationship with a sex buddy from years ago. He reasons that a less emotional attachment is exactly what he needs but soon learns that it's easier said than done.

When Marc's brother shows up on his doorstep after leaving his life, both mom and dad show up to "help." Things are immediately dysfunctional but when podcast guest David Cross gets everyone stoned (except Marc), they hash out their issues.

Marc is dreading an upcoming road trip. He's tired of doing the same old material and is anxious at the thought of writing new stuff but his anxiety reaches a peak when he discovers a sore that he believes to be mouth cancer.

Marc hits it off with Rachael Harris by comparing their bad relationship scars. When Marc pursues her, she wants him to prove he's over his anger issues by joining her yoga class.

During an appearance on a typically terrible morning radio show, Marc declares the medium dead, and the future belongs to podcasting. However, when he meets a largely ignored radio genius, he has a new respect for some DJs.

Trying to lead a simpler life, Marc immerses himself in his vinyl-collecting hobby but a chance encounter with a woman he meets in the record store parking lot snowballs into just the kind of chaos he’s been trying to avoid.

When Marc accidentally steals a joke from another comedian, he feels guilty. That guilt is put to the test when the comic insists Marc help his career in return.

As Marc's career reaches new heights, he is visited by an old acquaintance, desperate for a helping hand. After the comic passes away, Marc is forced to confront the reality that his success could disappear in an instant.