Battling severe depression in the wake of a suicide attempt, 46-year old Olivia hasn't left her Chicago basement in two years. With one last chance at a new life, Olivia will travel to Houston with the hope of having a life-changing surgery.

Zsaylnn, once known as the "Fat Girl Rock Star" - married a man who loves large women. Now weighing over 600lbs, she urgently needs to lose weight to be the mother her daughter deserves. Can Zsalynn succeed with a husband who doesn’t support her goals?

Chuck weighs almost 700lbs and it has hindered every aspect of his life. He's had to downsize his business and his wife feels like a single-parent, who is ready to leave him. Can Chuck take control and reclaim the life that's slipping through his fingers?

James comes from a long line of family obesity and at 706lbs, is determined not to die in the same hospital bed that his father and sister did. James vows to change his lifestyle in order to get gastric bypass, and even has hopes of dating again.

Tara is a mother of two from Lafayette, LA. Addicted to food, she is too ashamed of her size to be seen with her kids, confining herself indoors. Now seeking gastric bypass, Tara is committed to regaining her confidence and being a proud mother once more.

Christina is a 22-year old married woman from South Haven, Mississippi, who hasn't left her house in two years due to her size. Her doting family has enabled her and she's eaten herself into a state that will soon kill her, if she can't make a change.

Paula has had a tough life, and at over 600lbs, has built a physical wall around herself to push people away. When she suddenly loses someone she loves, Paula can no longer ignore the threat of losing her own life - especially for her children's sake.

Bedridden for four years, 46-year old Penny knows that her weight may kill her if drastic actions aren't taken. Penny moves from Maryland to Texas, to have gastric bypass - but her unwillingness to make real lifestyle changes could be her downfall.