Now bedridden and unable to care for herself, Lisa must find a way to lose the weight or she will never see her grandchildren grow up.

Fearing that he'll suffer the same fate as older brother David, now 700 pounds and unable to work, Benji hopes to be able to support both himself and his brother on their life-or-death weight loss journey.

Melissa has lost 500 pounds and saw her weight drop to 137 pounds, but now faces marital problems and life as a single mom, all while struggling with a gain of 150 pounds.

A devoted girlfriend and loving aunt, Alicia is all smiles and laughter on the outside, but on the inside she is terrified that her addiction to food will kill her before she can marry her long-time love or watch her nieces grow up.

A 24-year-old woman weighs more than 600 pounds and is fighting for her life after a difficult childhood with an abusive stepfather and drug-addicted mother.

A woman with two children weighs more than 600 pounds, so she agrees to go on an extreme new diet, but her weight-loss efforts are threatened by her debilitating habits and a child’s health emergency.

After years of a tumultuous relationship with her husband, Tamy's eating addiction causes her weight to balloon over 500 pounds; she becomes a hermit after years of shame and hopes to restart her life so she can better care for her son, Zachary.

After meeting and falling in love at a bariatric rehab center, Lee and Rena are battling health and anger issues while making a desperate, second attempt to save their lives.

James LB Bonner spent his early life trying to prove himself to his adoptive family, but after losing a leg and battling obesity, LB must take a new path to save his health and his family relationships.

Jennifer and her daughter, Marissa, are stuck in a co-dependent relationship that puts both of their lives in jeopardy, with a combined weight of more than 900 pounds; Jennifer strives to regain control before it's too late.

A 400-lb. woman learns that she's pregnant, but wonders if she'll be able to deliver the baby without complications; a woman who lost 400 pounds is in a relationship, but it could be in jeopardy when her weight-loss journey stalls.

A woman whose extreme obesity has left her nearly immobile must overcome both her physical and emotional pain if she is ever to live a normal life again.

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Devastated by two miscarriages due to her weight, Schenee is desperate to start a family and stop relying on her husband, Freddie, to take care of her; she hopes weight loss surgery will be able to fix her fertility issues as well as her marriage.

A former plus-size model and "big is beautiful" advocate, Renee realizes the mortal mistakes she made as her weight swells to 600 pounds and her health crumbles.

Lisa's struggle with her weight begins as a child and significantly worsens after witnessing her brother's murder; now bedridden and unable to care for herself, she must lose the weight or she will never see her grandchildren grow up.

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Back on Dr. Nowzaradan's program, James is suspected of cheating as he continues to gain weight and suffers a series of life-threatening illnesses. Cynthia continues to lose weight but seems satisfied to do so at her own pace.

Back on Dr. Nowzaradan's program, James is suspected of cheating as he continues to gain weight and suffers a series of life-threatening illnesses; Cynthia continues to lose weight but seems satisfied to do so at her own pace.

Losing over 200 pounds, Doug is now an active part of his family's lives and inspires a healthier lifestyle for them all. However, Doug's eating disorder and trouble finding his own identity threaten to derail his progress.

Ashley hits an emotional wall and is desperate for skin surgery, but she is not losing any weight. After being evicted, Nicole is forced to move back to Ohio, which could impact her weight loss journey.