650-lb Melissa struggles to get to her ideal weight.

Love motivates 660-lb Donald to begin his weight loss journey.

750-lb Henry begins his weight loss journey in the hopes of transforming himself in time to attend his high school reunion.

Ashley's career was derailed after she was let go due to her excessive weight. Will she be able to turn her life around and achieve her goal of owning a childcare facility?

Twins Kandi & Brandi have a combined weight totaling over 1100lbs. These inseparable twins fear losing each other to obesity, so they make a change together. But a life-threatening event during weight loss surgery recovery may separate them forever.

Cynthia is a 610-lb single mother raising five kids. She's been focused on her children, but now realizes what her death would mean for them. As she battles her emotions & the pressures of life, she is forced to fight harder to save her own life.

Weighing over 600-lbs Kirsten is close to losing her mobility. While she's trying to get control of her obesity she's also in danger of losing her troubled son. She must regain her health in order to be the best mother she can to care for her son.

Diana, a once thin & active woman, is now a prisoner to her 620lb body. Desperate to break free of her food addiction, she trades the comfort of her home for a weight loss journey under the strict authority of her niece in order to regain her life.

Michael's massive 632lb body has left him completely dependent upon his family. If he doesn't learn to control his anger issues around food, lose weight, and address the root of his issues, then he will remain in jeopardy of losing everything.

Weighing over 700-lbs, Nicole is on the verge of leaving her two young children motherless. Trying to survive a family of addicts, she commits to Dr Nowzaradan's diet program, but crisis threatens to derail all her hopes for weight-loss.

Tanisha weighs around 600-lbs and she's desperate to survive for her kids and avoid her mother's tragic fate of dying at age 50 from super obesity. Now at 32, her future looks grim if she doesn't make a drastic change to save her life.

Weighing 791-lbs, James is bedridden, unable to stand, and can barely move his legs. He may only have a few months to live, so his family takes a high-risk journey to Houston, Texas, with the hope that bypass surgery can save his life.

Most of the extreme weight on Tracey's body resides in her shockingly misshapen legs. They're so massive with severe lymphedema, that gastric surgery is her only chance of survival. Will this mother & grandmother ever gain control of her overeating?

Steven Assanti weighs nearly 800-lbs and his brother/nemesis, Justin, is almost 600-lbs. Though the brothers can't stand each other, their father packs up the family to travel across the country to seek help, desperate to save both his sons' lives.

After a year on a weight loss program, Steven remains completely non-compliant, and Justin focuses on a new career instead of his diet. With neither brother close to being approved for life-saving surgery, time is quickly running out for them.

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When Nathan's weight gets in the way of the only healthy thing in his life - his job as a drama teacher - it's a wake-up call for him. But changing his life might mean a falling out with his wife, Amber, who is also overweight, unless she can lose, too.

For Julian and his wife, Irma, it was love at first sight. But in order to grow old together, Julian will have to overcome the food addiction that made him more than 800 pounds, and Irma will have to hold on no matter how difficult the journey may become.

Bianca is all in for a move to Houston with her boyfriend and two young kids to get Dr. Now's help with a second weight-loss surgery. But just when the coast is clear, her boyfriend's change of mind could undermine her progress.

Mike was born with a talent for sports -- and an omnivorous appetite to match. After his football dreams were dashed by multiple concussions, he packed on over 700 pounds. Now he must find a new purpose in life to avoid succumbing to pain and regret.

Lacey is so big from overeating that she can barely leave the house, but that hasn't stopped her from finding love with Ricky. Her weight isn't the only thing between her and a happy husband, however, with Ricky's sister Sharon in the picture.

Paul weighs in at 700 pounds, and his girlfriend struggles with how this limits their ability to live a normal life; he thinks their relationship won't survive if he moves to work with Dr. Now, but prioritizing his own health is the only option.

Ryan moved to Montana to keep himself from going down a dark path of drug addiction. However, his new path may be no less lethal than the last if he can't find a way to curb his eating habits before they kill him.

For James B, food means family. He grew up eating rich Haitian food and loves it with a passion. Now, James needs Dr. Now's help to diminish that love in order to survive, but a death in the family sends James retreating back to the comforts he knows.