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Deshaun takes being protective of his mom to the next level. He's over 700 pounds and won't leave his mother's apartment. Dr. Now and Dr. Paradise might be able to get him to leave the bedroom, but will Deshaun ever make it to Houston?

Gary doesn't leave the bed anymore, he has his mom and a bevy of caretakers to get him what he needs; but his life is slipping away from him; he is so overweight that just getting to Houston may be out of the question.

Karen has gotten so out of control with her eating that she's developed a fear of leaving the house; she needs Dr. Now's help, but can Karen ever qualify for weight loss surgery if she won't leave the house?

Ashley is 24 and lives alone; her only sources of comfort are food and the relationships she has online; but not a single one of her profiles is real; Ashley learns that Dr Now isn't someone she can lie to like her online friends.

Tanisha weighs around 600-lbs and she's desperate to survive for her kids and avoid her mother's tragic fate of dying at age 50 from super obesity. Now at 32, her future looks grim if she doesn't make a drastic change to save her life.

Mercedes, who has severe lymphedema, must overcome trauma to lose weight.

At 24 years old and over 600 lbs, Megan lives at home with her mom, who cooks for her since Megan can't do much on her own; Megan must travel to Houston to meet Dr Now and change her eating habit or her life may end before it ever begins.

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Lisa wouldn't have made it this far without the help of her chief enabler, her boyfriend Randy. But Randy falls ill, and Lisa is about to find out if she has the will and determination she needs in order to turn her life around.

When a regular trip to the grocery store turns into an emergency for the EMTs, Delana must admit how badly she needs Dr. Now's help to lose weight. Hopefully her road to recovery will lead her to reconcile with the daughter she's grown apart from.

Lisa's struggle with her weight begins as a child and significantly worsens after witnessing her brother's murder; now bedridden and unable to care for herself, she must lose the weight or she will never see her grandchildren grow up.

Seana is 23 and nearly 700 lbs, living at her mom's house, depressed and anxious, her weight-gain threatening to take her last breath. Dr. Now can give her the tools she needs to live, but until she chooses life, no one can save Seana but Seana.

Bedridden for four years, 46-year old Penny knows that her weight may kill her if drastic actions aren't taken. Penny moves from Maryland to Texas, to have gastric bypass - but her unwillingness to make real lifestyle changes could be her downfall.

Weighing over 600-lbs Kirsten is close to losing her mobility. While she's trying to get control of her obesity she's also in danger of losing her troubled son. She must regain her health in order to be the best mother she can to care for her son.

A former plus-size model and "big is beautiful" advocate, Renee realizes the mortal mistakes she made as her weight swells to 600 pounds and her health crumbles.

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When Annjeannette was 9, a campaign was established to send her to fat camp. She hated that her weight had become a source of public shame and she has struggled to overcome her food addiction. Now, she must change her habits to save her life.

Cindy is resistant to change and has spent years creating a world that makes her feel safe. When her friend notices Cindy's health declining rapidly due to her size, she pushes Cindy to move to Houston and see Dr. Now. But Cindy isn't so easily persuaded.

Laura has used food to cope with her emotions for too long. Confined to a wheelchair, relying on an oxygen tank to breathe, she depends upon her husband and mother to survive. Love for her family must conquer her demons if she is to turn her life around.

At 600 pounds, Ashley has to move home so her mom can help her care for herself and her newborn daughter; Ashley must overcome a lifetime’s worth of unfortunate circumstances and get Dr. Now’s help in Houston.

Lacey ballooned up over 600 lbs on pizza and ice cream and knows Dr. Now is her best hope for success; she must now rally her divorced parents around her for support and find a way to modulate her moods that won't include binge-eating.

Born as "Matthew," Destinee never felt like she fit in; now, having come out as a 600-pound transgender woman, she likes her curves, but she will need to say goodbye to them if she wants to be approved to transition completely.

At over 600 pounds, Angie is trying to get to Houston to see Dr. Nowzaradan, in hope of getting weight loss surgery to save her life; family conflict and disagreements may stop her from being able to do what she needs before she even gets the chance.