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Back on Dr. Nowzaradan's program, James is suspected of cheating as he continues to gain weight and suffers a series of life-threatening illnesses. Cynthia continues to lose weight but seems satisfied to do so at her own pace.

Back on Dr. Nowzaradan's program, James is suspected of cheating as he continues to gain weight and suffers a series of life-threatening illnesses; Cynthia continues to lose weight but seems satisfied to do so at her own pace.

Losing over 200 pounds, Doug is now an active part of his family's lives and inspires a healthier lifestyle for them all. However, Doug's eating disorder and trouble finding his own identity threaten to derail his progress.

Ashley hits an emotional wall and is desperate for skin surgery, but she is not losing any weight. After being evicted, Nicole is forced to move back to Ohio, which could impact her weight loss journey.

Brittani has lost over 400 lbs. in two years. As part of her next chapter, will she and Bill start to plan to expand their family? Lupe has struggled since surgery. Having left her husband, will she finally start to make permanent changes she needs?

Gary doesn't leave the bed anymore, he has his mom and a bevy of caretakers to get him what he needs; but his life is slipping away from him; he is so overweight that just getting to Houston may be out of the question.

At 6'3 and over 700 pounds, Jacky has barely had a chance to live; she's never fit in anywhere; now that her parents have passed, she has a fresh chance to discover the world anew, but first she's got to lose 500 pounds; with bonus scenes.

Pastor Juan's love of food made him overweight, but it has never been a problem until recently, since he's gotten too big to preach and sing to his congregation. If Juan is to help others, he must first help himself by curbing his earthly appetite.

Deshaun takes being protective of his mom to the next level. He's over 700 pounds and won't leave his mother's apartment. Dr. Now and Dr. Paradise might be able to get him to leave the bedroom, but will Deshaun ever make it to Houston?

Karen has gotten so out of control with her eating that she's developed a fear of leaving the house; she needs Dr. Now's help, but can Karen ever qualify for weight loss surgery if she won't leave the house?

Ashley is 24 and lives alone; her only sources of comfort are food and the relationships she has online; but not a single one of her profiles is real; Ashley learns that Dr Now isn't someone she can lie to like her online friends.

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Mercedes, who has severe lymphedema, must overcome trauma to lose weight.

At 24 years old and over 600 lbs, Megan lives at home with her mom, who cooks for her since Megan can't do much on her own; Megan must travel to Houston to meet Dr Now and change her eating habit or her life may end before it ever begins.

Tanisha weighs around 600-lbs and she's desperate to survive for her kids and avoid her mother's tragic fate of dying at age 50 from super obesity. Now at 32, her future looks grim if she doesn't make a drastic change to save her life.

Krystal S. has finally met the man of her dreams, but she won't let herself marry him until she can be sure that she won't become bedridden and force him into the role of caretaker.

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Seana is 23 and nearly 700 lbs, living at her mom's house, depressed and anxious, her weight-gain threatening to take her last breath. Dr. Now can give her the tools she needs to live, but until she chooses life, no one can save Seana but Seana.

When a regular trip to the grocery store turns into an emergency for the EMTs, Delana must admit how badly she needs Dr. Now's help to lose weight. Hopefully her road to recovery will lead her to reconcile with the daughter she's grown apart from.

A former plus-size model and "big is beautiful" advocate, Renee realizes the mortal mistakes she made as her weight swells to 600 pounds and her health crumbles.