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The Best Episodes of Mystery Diagnosis

Every episode of Mystery Diagnosis ranked from best to worst. Let's dive into the Best Episodes of Mystery Diagnosis!

Binge this in 3d 16h•Peaking at 9.6/10

Mystery Diagnosis is a television program that airs on the OWN: Oprah Winfrey Network. Each episode focuses on two or more individuals and their struggles to find out what ailments they suffer from. As the

Airs on
Discovery Health Channel
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Episode Rankings

  1. #1 Fan Favorite
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    Mystery Diagnosis Season 5 Episode 3 - The Woman Who Kept Falling Down
    9.6/10(6 votes)

    #1 - The Woman Who Kept Falling Down

    S5:E3

    A baby boy has bouts of vomiting and diarrhea from the day of his birth; a young woman experiences blackouts after she hits puberty.

    Director:Unknown
    Writer:Unknown

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  2. Mystery Diagnosis Season 5 Episode 9 - The Woman Who Couldn't Cry
    9.3/10(7 votes)

    #2 - The Woman Who Couldn't Cry

    S5:E9

    Doctors can't pinpoint the cause of the array of debilitating ailments a woman has been suffering from for more than 50 years.

    Director:Unknown
    Writer:Unknown

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  3. Mystery Diagnosis Season 3 Episode 4 - The 13 Year Stomach Ache
    9.2/10(7 votes)

    #3 - The 13 Year Stomach Ache

    S3:E4

    A teenager is rushed to the hospital after taking aspirin to help alleviate altitude sickness; a woman has pain in her arm that mysteriously spreads.

    Director:Unknown
    Writer:Unknown

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  4. Mystery Diagnosis Season 5 Episode 10 - The Woman With a Knife in Her Head
    9.2/10(7 votes)

    #4 - The Woman With a Knife in Her Head

    S5:E10

    Amanda Coveler, a woman who successfully gives birth to a second daughter after two miscarriages, faces challenges after giving birth.

    Director:Unknown
    Writer:Unknown

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  5. Mystery Diagnosis Season 6 Episode 10 - The Black and Blue Baby
    9.2/10(5 votes)

    #5 - The Black and Blue Baby

    S6:E10

    Holly is overjoyed at the birth of her second baby, Hannah Hannum, but soon realizes that she has Down syndrome; Carly and Nathan have just gotten married, when Carly falls extremely ill with strong nausea.

    Director:Unknown
    Writer:Unknown

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  6. Mystery Diagnosis Season 3 Episode 3 - Deadly Sore Throat
    9.0/10(6 votes)

    #6 - Deadly Sore Throat

    S3:E3

    A man suffers from a series of debilitating symptoms; doctors cannot diagnose his illness, but thanks to a chance meeting this mystery will be solved; a woman undergoes a risky left temporal craniotomy.

    Director:Unknown
    Writer:Unknown

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    The 20 WORST Episodes of Mystery Diagnosis

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  7. Mystery Diagnosis Season 3 Episode 5 - The Bearded Lady
    9.0/10(5 votes)

    #7 - The Bearded Lady

    S3:E5

    A woman and her husband decide to start a family after numerous negative pregnancy tests; a man appears to suffer an embolism

    Director:Unknown
    Writer:Unknown

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  8. Mystery Diagnosis Season 9 Episode 7 - The Toddler That Went Through Puberty
    8.8/10(8 votes)

    #8 - The Toddler That Went Through Puberty

    S9:E7

    A three-year-old's unexplained vaginal bleeding sends her parents searching for answers to help their baby girl. Also, a student plagued by cramps is unable to hold her food down.

    Director:Unknown
    Writer:Unknown

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  9. Mystery Diagnosis Season 9 Episode 8 - The Toddler That Stopped Walking
    8.8/10(9 votes)

    #9 - The Toddler That Stopped Walking

    S9:E8

    A mother rushes her toddler to hospital when she loses the ability to walk or stand. Plus, a runner tries to sleep off a numbness in his foot, but finds the sensation spreading.

    Director:Unknown
    Writer:Unknown

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  10. Mystery Diagnosis Season 10 Episode 9 - Stolen Senses
    8.8/10(5 votes)

    #10 - Stolen Senses

    S10:E9

    A viral infection paralyzes Tammy from the chest down. Nadine's world is disappearing before her eyes as an unknown condition slowly steals her eyesight.

    Director:Unknown
    Writer:Unknown

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  11. Mystery Diagnosis Season 10 Episode 5 - A Family's Desperate Search
    8.7/10(6 votes)

    #11 - A Family's Desperate Search

    S10:E5

    Since birth, Ricky is plagued by respiratory infections and a bizarre inability to grow. Noel is a healthy, active man until mysterious spasms start taking over his life.

    Director:Unknown
    Writer:Unknown

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  12. Mystery Diagnosis Season 10 Episode 2 - Trapped Inside Their Bodies
    8.6/10(5 votes)

    #12 - Trapped Inside Their Bodies

    S10:E2

    A young man has strange growths; toddler rapidly gains weight.

    Director:Unknown
    Writer:Unknown

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  13. Mystery Diagnosis Season 10 Episode 3 - Dangerous Growths
    8.6/10(5 votes)

    #13 - Dangerous Growths

    S10:E3

    A woman starts growing uncontrollably. A boy coughs up raspberry-like growths.

    Director:Unknown
    Writer:Unknown

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  14. Mystery Diagnosis Season 10 Episode 7 - Too Young To Be Sick
    8.6/10(7 votes)

    #14 - Too Young To Be Sick

    S10:E7

    Harry's body starts to undergo a mysterious transformation. Sadie finds herself on the brink of starvation after her doctor dismisses her complaints.

    Director:Unknown
    Writer:Unknown

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  15. Mystery Diagnosis Season 8 Episode 3 - The Boy Who Couldn't Stop Eating
    8.5/10(7 votes)

    #15 - The Boy Who Couldn't Stop Eating

    S8:E3

    After blisters appear all over the body of young Julie McCawley, she appears to have Stevens-Johnson syndrome; Conor Heybach's weight gain and uncontrollable appetite is a mystery until a doctor discovers he has Prader-Willi syndrome.

    Director:Unknown
    Writer:Unknown

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  16. Mystery Diagnosis Season 10 Episode 4 - When the Body Shuts Down
    8.5/10(6 votes)

    #16 - When the Body Shuts Down

    S10:E4

    When Kylie is born struggling to breathe, doctors aren't sure whether they will find a cure. Also, athlete Michael is left fighting for his life when a sore throat turns deadly.

    Director:Unknown
    Writer:Unknown

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  17. Mystery Diagnosis Season 6 Episode 6 - The Boy Who Kept Swelling
    8.4/10(8 votes)

    #17 - The Boy Who Kept Swelling

    S6:E6

    An 18-month-old baby suddenly starts screaming one afternoon in the pool, and begins exhibiting extremely painful symptoms when exposed to sunlight, with porphyria later found to be the culprit. A mother of two children begins to suffer a series of very debilitating headaches.

    Director:Unknown
    Writer:Unknown

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  18. Mystery Diagnosis Season 9 Episode 2 - The Boy Who Only Hopped
    8.4/10(7 votes)

    #18 - The Boy Who Only Hopped

    S9:E2

    After moving houses, and months of strange behavior, 12-year-old Sammy stops walking and only hops; the doctors are the only hope to discover the cause of his bizarre symptoms. He is eventually diagnosed with PANDAS, a condition in which antibodies mistake his brain for Streptococcus bacteria.

    Director:Unknown
    Writer:Unknown

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  19. Mystery Diagnosis Season 8 Episode 1 - The Woman Whose Legs Turned Black
    8.3/10(7 votes)

    #19 - The Woman Whose Legs Turned Black

    S8:E1

    Diane finds two small, red bumps on her foot; within hours her foot is swollen and appears black and blue; despite undergoing tests, the medical team has no diagnosis.

    Director:Unknown
    Writer:Unknown

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  20. Mystery Diagnosis Season 2 Episode 1 - A Puff of Smoke
    8.2/10(5 votes)

    #20 - A Puff of Smoke

    S2:E1

    A baby is irritable, has trouble nursing and stops gaining weight. When the infant begins suffering repeated seizures and eventually begins sustaining rapid-onset cerebral ischemia, they are diagnosed with moyamoya disease, and must be treated before they suffer lethal brain damage from the repeated ischemic incidents. A man initially diagnosed with hypoglycemia finds out he's got a tumor in his lung. A woman battling coughs, hives, and muscle weakness, was revealed to have an elevated eosinophil count.

    Director:Unknown
    Writer:Unknown

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  21. Mystery Diagnosis Season 9 Episode 5 - The Girl With No Bowel
    8.2/10(6 votes)

    #21 - The Girl With No Bowel

    S9:E5

    After suffering a series of debilitating incidents believed to be the result of Crohn's disease, Karen, an albino, has to have most of her colon removed. Several decades later, at the age of 38, she receives a phone call from someone who suggests she is suffering from a rare and fatal disease, Hermansky-Pudlak syndrome, which is also the cause of her albinism.

    Director:Unknown
    Writer:Unknown

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  22. Mystery Diagnosis Season 3 Episode 1 - Sleeping Beauty
    8.0/10(7 votes)

    #22 - Sleeping Beauty

    S3:E1

    A girl sleeps for ten days in a row, but tests are normal and doctors are perplexed; a marathon runner experiences unexplainable fatigue.

    Director:Unknown
    Writer:Unknown

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  23. Mystery Diagnosis Season 9 Episode 1 - The Woman Whose Flesh Was Eaten Alive
    8.0/10(6 votes)

    #23 - The Woman Whose Flesh Was Eaten Alive

    S9:E1

    June has a biopsy and, when a mark appears on the site, she has surgery, leaving her with a growing open wound. Her doctor diagnoses her with a flesh eating virus. Can June's life be saved?

    Director:Unknown
    Writer:Unknown

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  24. Mystery Diagnosis Season 9 Episode 9 - The Woman With Unusual DNA
    8.0/10(8 votes)

    #24 - The Woman With Unusual DNA

    S9:E9

    When Jeanne fails to hit puberty, doctors discover that something truly bizarre is the cause; analysis of her DNA finds that she is genetically male, possessing Y chromosomes, but due to the rare genetic disorder Swyer syndrome, she appears outwardly female. Mary is stricken with a collapsed lung and breathing problems.

    Director:Unknown
    Writer:Unknown

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  25. Mystery Diagnosis Season 6 Episode 8 - The Boy Who Bit Himself
    7.9/10(7 votes)

    #25 - The Boy Who Bit Himself

    S6:E8

    Parents notice their 7-month-old son has troubling physical impairments, then begins violently harming himself, culminating in a horrifying incident where the child bites off his own lower lip; he is later diagnosed with the genetic condition Lesch-Nyhan syndrome. A woman traveling the world starts experiencing unusual back pain and tingling in her feet that rapidly develops into a spreading paralysis; following the successful use of plasmapheresis, the cause of the dangerous condition is identified as Devic's disease, an inflammation of the spinal cord.

    Director:Unknown
    Writer:Unknown

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Best Episodes Summary

"The Woman Who Kept Falling Down" is the best rated episode of "Mystery Diagnosis". It scored 9.6/10 based on 6 votes. Directed by Unknown and written by Unknown, it aired on 1/28/2008. This episode scored 0.3 points higher than the second highest rated, "The Woman Who Couldn't Cry".