Doctors can't pinpoint the cause of the array of debilitating ailments a woman has been suffering from for more than 50 years.

Amanda Coveler, a woman who successfully gives birth to a second daughter after two miscarriages, faces challenges after giving birth.

A baby boy has bouts of vomiting and diarrhea from the day of his birth; a young woman experiences blackouts after she hits puberty.

Trisha and David Kielb's baby is born, but soon afterwards the heart stops, turning their joy into fear; a woman experiences excruciating headaches.

A 12-year-old girl experiences abdominal pains and severe headaches until she is diagnosed with a retroflexed odontoid and Chiari One malformation; a firefighter and paramedic is diagnosed with acquired immunodeficiency syndrome (AIDS).

A woman has shortness of breath, chest and joint pain, extreme fatigue, and a cough; strange symptoms appear in an energetic kindergartener.

A husband is rendered helpless by back pain. An overweight girl experiences dizziness and shortness of breath with any physical exertion.

Lavelle Fernandez and Roddy Palma's baby girl inexplicably turns blue 30 minutes after her birth; Laurie Scott suffers from excruciating headaches that won't go away.

Since birth, Ricky is plagued by respiratory infections and a bizarre inability to grow. Noel is a healthy, active man until mysterious spasms start taking over his life.

Harry's body starts to undergo a mysterious transformation. Sadie finds herself on the brink of starvation after her doctor dismisses her complaints.

When Kylie is born struggling to breathe, doctors aren't sure whether they will find a cure. Also, athlete Michael is left fighting for his life when a sore throat turns deadly.

A baby who cries and holds her cheek; a woman who gained 100 pounds in three months and developed severe acne; and an avid athlete struggling to catch his breath. Featuring trigeminal neuralgia, polycystic ovary syndrome and alpha-1 antitrypsin deficiency.

Nicole is a teenager who feels excruciating pain in her jaw and her face starts to sink, with her affliction later found to be the result of Parry-Romberg syndrome. Kevin thinks he has food poisoning, but he starts to lose motor coordination.

Over the first several years of their life, a young girl experiences bouts of debilitating pain and degradation to her bones caused by lymphangiomatosis.

A man tries to ease his wife's sinus pains, while a woman faces her own mortality when she experiences a series of debilitating symptoms.

Doctors are baffled by a woman's mysterious respiratory problem. Featuring Cushing's syndrome, gout, carcinoid cancer.

A child with celiac disease is intolerant of gluten; a woman has her left frontal lobe removed to stop seizures; another woman suffers from fatigue and mood swings. Featuring celiac disease, mitral valve prolapse (MVP), epilepsy.

A child with Hurler's disease undergoes a stem-cell transplant procedure; a woman is diagnosed with myasthenia gravis; A father has seizures and fainting spells due to a heart arrhythmia. Featuring Hurler syndrome, myasthenia gravis, cardiac arrhythmia.

A young boy's body is not producing antibodies to fight infections; a cancerous tumor must be removed; a woman loses the ability to walk. Featuring common variable immunodeficiency (CVID), gastrointestinal stromal tumor (GIST), reflex sympathetic dystrophy (RSD).

A 5-year-old has a persistent fever and stomachache. A man crippled with a neck tilt. A woman falls ill after traveling abroad. Featuring Crohn's disease, cervical dystonia, brucellosis.

Two brothers suffer the same heart problem. Joanne suffers from joint pain, mouth ulcers, genital sores, skin lesions, and vision problems. Featuring Barth Syndrome, Behcet's Disease

A baby is irritable, has trouble nursing and stops gaining weight. When the infant begins suffering repeated seizures and eventually begins sustaining rapid-onset cerebral ischemia, they are diagnosed with moyamoya disease, and must be treated before they suffer lethal brain damage from the repeated ischemic incidents. A man initially diagnosed with hypoglycemia finds out he's got a tumor in his lung. A woman battling coughs, hives, and muscle weakness, was revealed to have an elevated eosinophil count.

A baby drinks excessively, projectile vomits and stops growing. A professional baseball player's wife struggles to get pregnant due to a brain tumor. An old man is robbed of his eyesight.

Parents deal with a son with sinus infections and unsteady feet; a woman gains weight and has oily skin, hair loss, body cramps and irritable bowel syndrome. A reverend has trouble sleeping.

A man has suffered from vertigo and ear infections since childhood. A 16-year-old girl has headaches and neck twitching, that led to preeclampsia. A girl has a serious heart condition and stops growing and gaining weight.