Nicole is a teenager who feels excruciating pain in her jaw and her face starts to sink, with her affliction later found to be the result of Parry-Romberg syndrome. Kevin thinks he has food poisoning, but he starts to lose motor coordination.

Over the first several years of their life, a young girl experiences bouts of debilitating pain and degradation to her bones caused by lymphangiomatosis.

A woman experiences strange symptoms after breast reduction surgery; though the symptoms are initially attributed to the surgery, she is eventually diagnosed with inflammatory breast cancer. A baby has severe developmental delays, difficulty eating, and jerky movements; her unusually happy demeanor eventually leads to a diagnosis of Angelman syndrome.

A woman experiences numerous unusual symptoms as a result of being infected by the bacteria Serratia marcescens, including an incident where her breast milk turns pink after being dyed with a chemical produced by the bacteria. An infant begins experiencing intense pain in their hip.

A young mother begins to have panic attacks and has a seizure; she experiences episodes of paranoia and delusions after being released from the hospital, which later escalate to outbreaks of intense violence after she is admitted once again. The cause is later found to be a teratoma and the body's attempts to get rid of it with an immune response, inadvertently targeting the brain in the form of Anti-NMDA receptor encephalitis. A truck driver and father of two had been caught off guard by mysterious pains in his feet. Later, he was experiencing temperature changes and the pain increased to the point where he had to quit his job. All hope was lost until a vascular specialist diagnosed him with Buerger’s disease on account of his heavy smoking.

For years, Mary has had a problem with constant belching; now having difficulty breathing, she is seen by gastroenterologist Dr Chey, who discovers something he has never seen before and diagnoses her with Congenital diaphragmatic hernia. Pam was an excellent ER nurse who seemed to have a good handle on her health, until she was struck with headaches, unequal pupils, and facial numbness; When cardiologist Dr Yadav saw her angiogram, he diagnosed her with Fibromuscular dysplasia

A couple fear for their child when they discover that he does not cry when he is in pain; a woman in her thirties suffers inexplicable seizures.

Baby Samantha has surgery to remove congenital cataracts that could lead to blindness; as the months pass, Samantha is unable to roll, crawl or talk, and her head is unusually small for her age; her parents seek help. When her newborn brother begins exhibiting the same symptoms, a genetic test finds that the two children are sufferers of Cockayne syndrome, a genetic disorder which causes premature aging.