While Cruz is in care, Jackie goes over his head to get the ER under control, resulting in her dismissal from All Saints for insubordination. Jackie pulls Grace out of Catholic school. O'Hara goes into labour and Jackie returns to All Saints in spite of Cruz. Charlie arrives at the ER and Cruz asks Jackie to help him save Charlie's life.

Coop gets a surprise. Jackie hits the road. Season finale.

It's Jackie's one year anniversary of sobriety and she and Frank fight about their relationship. Zoey acts very professional and rigid around Prentiss after their intimate evening. Carrie's peer review does not go well. Grace has a breakdown about Jackie. Jackie takes something she shouldn't have.

In the season finale, Jackie returns to All Saints where she must confront everyone.

Jackie reluctantly attends Kevin's wedding. Carrie makes demands on Coop.

Jackie breaks up with Frank and tries to separate herself from the people closest to her so she can keep using drugs. Meanwhile, Carrie forgets Coop's 40th birthday; the DEA investigation intensifies; and Zoey decides to become a nurse practitioner.

Picking up with her arrest, Jackie suffers through detox.

Kevin invites Jackie to a midnight rendezvous in order to give her a new wedding ring; the comatose movie critic wakes up but his tastes have radically changed.

Jackie covers for Cruz when he has a panic attack; Zoey surveys her coworkers for the best ways to conduct a breakup; Akalitus enlists the staff in an elaborate charade when her mentor is admitted with dementia.

Things get out of control in the emergency room due to the recent firings and an overflow of patients who have been diverted from another hospital, causing Cruz to suffer a pulmonary episode and Jackie to step in. At home, a rebellious Grace refuses to go to class unless Jackie transfers her to public school.

Akalitus forgets to hire an escort for a psych patient who then lays waste to the pharmacy; Frank cancels a lunch date with Jackie; Zoey hears Coop and Carrie having sex; Jackie worries about Frank when she learns that a cop has been shot.

Jackie gets offered a job - and wants Zoey to come with her. Series finale.

Jackie is caught off-guard when a nurse (Judith Ivey) she used to work with, who is dying of lung cancer, asks Jackie to help end her life. Meanwhile, Coop’s mother (Blythe Danner) is admitted with a gall bladder attack. We learn that he is the only son of lesbians…a fact that delights Jackie and O’Hara.

When HR demands urine samples from all the nurses, Jackie tries to avoid it as long as possible as well as her husband, who seems to have found out about her affair with Eddie.

When Cruz learns about Jackie's rehab, he takes revenge on coworkers who have been covering up her drug problems. Meanwhile, Eddie is deposed by Kevin's lawyer; a dumped Lenny decides to take off for Europe; and Coop accompanies O'Hara to her ob-gyn appointment.

Jackie's fake identity is compromised when it's learned that Carrie's DEA number has been stolen by a woman named Nancy Wood. Meanwhile, Jackie worries about her dwindling bank account and lack of pills; and Prentiss gives Zoey a shocking message.

An unexpected knock at the door puts Jackie and Eddie in jeopardy.

Jackie is forced to perform a procedure on her own. Zoey learns a secret.

Jackie and Frank have sex for the first time and he tells her he loves her. Akalitus has an extra spring in her step. Coop wants to take his mentoring of Carrie to the next level. Kevin and Grace show up at the hospital after Kevin finds a bag of pills in Grace's bag.

Jackie is ambushed by Antoinette. Coop's dream finally comes true.

Jackie gets inventive, setting her sights on returning to All Saints.

Zoey finally confronts Jackie. Dr. Prince attracts a mob to All Saints.

Jackie and Grace begin mother-daughter tap class. Coop threatens to expose Jackie for falsifying a donor’s record. Jackie has forgotten to remove her wedding ring, and needs to get it off before meeting Eddie for a quickie.

Kevin decides to buy Jackie a new wedding ring. At work, the automated pill machine replaces Eddie. A movie critic is admitted with a broken elbow.

In order to keep her secret credit card a secret, Jackie sets up a P.O. box for the credit card bills. In the meantime, Mrs. Akalitus offers Eddie to come back as the hospital's pharmacist.