Akalitus forgets to hire an escort for a psych patient who then lays waste to the pharmacy; Frank cancels a lunch date with Jackie; Zoey hears Coop and Carrie having sex; Jackie worries about Frank when she learns that a cop has been shot.

Just when Jackie has run out of pills, she runs into a confrontation about the drugs from Oncology that disappeared. Coop tracks down an old girlfriend on Facebook when he decides to start his own family. Heart problems make Zoey revisit her relationship with Lenny.

Following HR's inquiry of the missing drugs, Mrs. Akalitus puts Jackie on probation. Meanwhile, Coop plans his wedding and Jackie's daughter Grace wants to be put on medication for her anxiety disorder.

Jackie tries to stay sober and get through probation until Dr. O'Hara has a tempting offer for her. Meanwhile Eddie believes Kevin found out about the affair and Zoey throws a party for her colleagues.

When HR demands urine samples from all the nurses, Jackie tries to avoid it as long as possible as well as her husband, who seems to have found out about her affair with Eddie.

Jackie covers for Cruz when he has a panic attack; Zoey surveys her coworkers for the best ways to conduct a breakup; Akalitus enlists the staff in an elaborate charade when her mentor is admitted with dementia.

Kevin demands full custody. A bus crash patient returns after contracting sepsis. Coop threatens to quit.

It's Jackie's one year anniversary of sobriety and she and Frank fight about their relationship. Zoey acts very professional and rigid around Prentiss after their intimate evening. Carrie's peer review does not go well. Grace has a breakdown about Jackie. Jackie takes something she shouldn't have.

After breaking up with Kevin, Jackie has to realize she needs professional help. Meanwhile, a new director at the hospital makes some personnel changes and Kevin finds out about Jackie and Eddie's affair.

Coop gets a surprise. Jackie hits the road. Season finale.

Jackie accuses Kelly of being inappropriate with two flirty high school girls; Coop begins to let go of childish things; Thor counsels Akalitus on her new phone system and some deeper matters; Jackie is unexpectedly delayed getting to Grace's pageant.

While Cruz is in care, Jackie goes over his head to get the ER under control, resulting in her dismissal from All Saints for insubordination. Jackie pulls Grace out of Catholic school. O'Hara goes into labour and Jackie returns to All Saints in spite of Cruz. Charlie arrives at the ER and Cruz asks Jackie to help him save Charlie's life.

Kevin interrupts Jackie and Frank's night. Akalitus' blood results are in and her memory loss is a result of a medication she's been taking. Zoey helps Prentiss organize his disaster of an office. Meanwhile, Jackie is convinced that Grace is sneaking behind her back to see Danny, but Grace assures her they broke up. Frank urges Jackie to work on her issues - so she attends an AA meeting.

Jackie breaks up with Frank and tries to separate herself from the people closest to her so she can keep using drugs. Meanwhile, Carrie forgets Coop's 40th birthday; the DEA investigation intensifies; and Zoey decides to become a nurse practitioner.

In the season finale, Jackie returns to All Saints where she must confront everyone.

In the Season 3 premiere, Jackie's marriage is strained, as is her relationship with O'Hara after the intervention; Akalitus warns the staff that nearby hospitals have closed down, straining the staff and resources; Zoey publicly confesses her affair with Lenny.

Jackie and Grace recover from their nights of indiscretion; Carrie uses flashcards to strengthen her skills.

Jackie and Frank have sex for the first time and he tells her he loves her. Akalitus has an extra spring in her step. Coop wants to take his mentoring of Carrie to the next level. Kevin and Grace show up at the hospital after Kevin finds a bag of pills in Grace's bag.

Jackie reluctantly attends Kevin's wedding. Carrie makes demands on Coop.

Picking up with her arrest, Jackie suffers through detox.

Kevin invites Jackie to a midnight rendezvous in order to give her a new wedding ring; the comatose movie critic wakes up but his tastes have radically changed.

Jackie gets offered a job - and wants Zoey to come with her. Series finale.

Jackie is caught off-guard when a nurse (Judith Ivey) she used to work with, who is dying of lung cancer, asks Jackie to help end her life. Meanwhile, Coop’s mother (Blythe Danner) is admitted with a gall bladder attack. We learn that he is the only son of lesbians…a fact that delights Jackie and O’Hara.

An unexpected knock at the door puts Jackie and Eddie in jeopardy.

Jackie is forced to perform a procedure on her own. Zoey learns a secret.