Victims of a bus accident are treated; two doctors join the rotation; O'Hara is happy spending time with her son; Akalitus gives Eddie his job back.

Jackie runs out of drugs and Dr. Cooper decides to compete with Dr. O'Hara for the E.R. chief position.

Jackie steals Dr. Roman's DEA number. Coop is recruited by a 'sperm scout.'

Jackie's back to using again, but she's doing it differently this time: maintaining a clean and sober cover, going to 12-step meetings - even finding herself a sponsor - all the while getting her drugs from the towel girl at the gym. Meanwhile at All Saints, Zoey finds out that everyone knows about her 'secret' relationship with Prentiss. Season premiere.

Kevin's younger sister Tunie visits after a breakup with her boyfriend; Lenny prepares a surprise romantic picnic for Zoey; two street vendors are brought in after a turf war turns violent; Akalitus fights Catholic bureaucrats over the hospital's chapel.

Jackie finds a new hiding place for her pills and buries the hatchet with O'Hara, who becomes ER chief; Zoey works her first double shift; Kevin invites Eddie to a backyard barbecue; Jackie must tell more lies to retrieve her misplaced stash.

Jackie's life gets a little more complicated because of a security guard and O'Hara's longtime affair comes to light.

Coop learns his sperm count is too low for donation; Carrie gets a lucky break; Akalitus' poker habit pays off; Grace drops a bomb on Jackie.

A man is admitted with a steak knife sticking out of his chest. Eddie gives Jackie a Cartier bracelet for their one-year anniversary, but she rejects the gift. A baby is left in the nurses’ station and Akalitus takes the infant to her office.

Jackie admits a patient she has treated before. As his condition worsens, Zoey questions whether Jackie did enough to help him on his previous visit. Jackie’s drug use starts to cause spontaneous nose bleeds.

Mrs. Akalitus is in a holy uproar as workers from the archdiocese remove her religious statues. Meanwhile, a new temp nurse makes his presence known in the ER, and some people don't appreciate it; Coop deals with personal, professional and podiatric problems; and Jackie tries to deal with Kevin playing matchmaker between Eddie and his sister.

Kelly wins over the All Saints staff; Kevin finds pills in a dental floss dispenser; a patient soothes Coop's depression; Jackie pockets drugs.

Jackie detoxes at home - with help. Frank raises an objection about Grace.

Zoey leads the ER nurses on a walkout. Jackie battles her cravings.

Longtime ER nurse Jackie Peyton bends the rules to bring some good from a patient's senseless death, while concealing her addiction to a pain killer she gets from her boyfriend, the hospital pharmacist.

An elderly patient checks in who has been treating his heart disease with chicken soup; Jackie discusses her daughter's anxiety with Dr. O'Hara; Eddie learns that he is to be replaced by a pill-dispensing machine.

Jackie and Kevin consider enrolling Grace in private school; the stoic Dr. O'Hara must endure the emotional thanks of a boy whose twin brother she saved; Zoey loses a patient for the first time.

After the confrontation with Eddie at the end of season one, it’s now a few months later. Jackie has cut ties with Eddie and is determined to dive back in and spend more time with her family. Back at All Saints, she deflects blame about the narcotic shortage and endures Sam, the altered nurse and his newfound sobriety.

Jackie covers for a hung-over O'Hara, while Eddie befriends Kevin and Dr. Coop gets hooked on microblogging.

O'Hara offers financial help, but Jackie and Kevin refuse to take it. Eddie and Kevin's secret friendship is revealed.

Coop insults the biggest donor of the hospital while Jackie revisits her affair with Eddie.

Worried about her daughter, Jackie leaves rehab early against her therapist's advice and finds that returning to work greatly rattles her nerves, forcing her to struggle to maintain her sobriety; Zoey has second thoughts about her relationship with Lenny; Eddie tells Jackie that he confessed their affair to Kevin.

Jackie and her husband, Kevin, become concerned that their older daughter Grace is suffering from anxiety disorder; hospital administrator Mrs. Akalitus drinks Jackie's Percoset-laced coffee.

Jackie breaks several rules and regulations to help a 10-year-old girl caring for her lupus-stricken mother; Mrs. Akalitus accidentally tasers herself; O'Hara treats Zoey to a meal at a four-star restaurant.

Jackie discovers that a new temp nurse is abusing drugs, but when she confronts him, he calls her on hypocrisy; Mrs. Akalitus still has the foundling infant left at the hospital; Coop reveals to Eddie that Jackie has a child.