After Charlie’s hand moved in the last episode, Alex has high hopes for his recovery, while she treats a patient who already has multiple surgeries under his belt. Meanwhile, Charlie coaches a young man killed in a roofing accident who has unfinished business with his severely injured brother.

Two patients need the same heart; a patient has never-before-seen orthopaedic hardware; Dr. Maggie Lin feels the pressure of the upcoming boards.

Alex encounters a trapped teenager during a hike in the woods; a woman refuses to see anyone but Joel; an exotic dancer comes to the ER.

Alex and Maggie deal with a tough lawyer after surgical complications with their cancer study patient. With the E.R. now an urgent care facility, Zach and his team aren't equipped to handle an accident victim.

Alex returns to work for the first time since her stabbing. She is introduced to her buddy colleague, as she returns. Joel ends up involved in a deadly situation at a local street clinic. Gavin shares a euphoric experience, with someone unlikely.

Alex and Maggie perform an intricate procedure; Joel thinks his dad is hiding something; Charlie suspects foul-play when he sees a boy and his grandmother.

Alex and Charlie are confused about their relationship. Alex and Maggie disagree about a car crash survivor. Dana is forced to treat an injured motorcyclist. Zach bothers Maggie about dating.

Charlie tries to save the arm of a man thrown from a horse. Alex joins Manny off-site to help a runaway. A rival from Dev's past arrives at Hope Zion.

While Charlie tries to save a young man's life, he is haunted by a mischievous spirit.

Alex and Charlie rush to the scene of a mass casualty accident involving a bus full of teenagers.

Alex and Maggie ask Charlie for his opinion on a patient's treatment. Zach is persuaded by a patient while transitioning the ER to an urgent care facility.

Charlie and Manny treat a couple. Maggie evaluates the interns. Billy asks Maggie to be his mentor. Dawn tries to get her Chief of Surgery position back.

The doctors rally together to try to save an unknown man who was struck by a subway train. Randal delivers a warning about Charlie's gift. Dr. Sydney Katz returns to town.

Alex and Maggie work together to deliver a baby. Charlie treats a magician.

Alex tries to help patient who hurt himself breaking into a house. A friend of Dr. Dev Sekara has been beaten by the police; a heart patient wishes to open an animal sanctuary.

Alex has to put her concerns for Charlie aside when a chance to perform a cancer surgery arises.

Kristine shows up at the hospital with baby Luke's blanket.

Alex and Charlie perform a double surgery on a teenage girl; Joel works at the clinic; Maggie must pull through when she is reunited with the Zarb family.

When Joel gets cold feet in the OR, Kinney takes him with her on a Continuing Medical Education assignment in her hometown to help clear his head. During their field trip, a woman gets pinned underneath a truck and Joel and Kinney lead the rescue effort. Meanwhile, Charlie meets a newly deceased therapist who suspects it’s an emotional block that is keeping him in his coma. Encouraged by Charlie breathing on his own, Alex continues her rounds and diagnoses a fitness buff with a rare condition.

Alex makes a promise to a young girl on her birthday. Maggie organizes a surprise party for Alex. Cassie is forced to confront her fear of infectious diseases.

Alex is challenged about the value of holistic medicine. Charlie's abilities are questioned. Two filmmakers go to Hope Zion Hospital.

The board questions the hospital staff about Charlie's behaviour. A patient convinces Alex to use new-age techniques. Shahir agrees to do an in-utero surgery.

In the premiere episode, the Chief of Surgery ends up in a coma, and his fiancée and fellow surgeons fight to save his life.

A sleep-deprived Alex takes on a night shift in the ER where an all-star hockey enforcer may be skating full-speed towards an early death. Meanwhile, Charlie meets a suburban punk who is facing the biggest fight of his life.

A high profile double hand replantation becomes Alex's (Durance) chance to prove to Kinney (Wendy Crewson) that she is still capable of being Chief Surgical Resident. In the ICU, Maggie (Ross) believes a homeless man may have been misdiagnosed.