Alex and Charlie rush to the scene of a mass casualty accident involving a bus full of teenagers.

In the premiere episode, the Chief of Surgery ends up in a coma, and his fiancée and fellow surgeons fight to save his life.

Alex and Charlie are confused about their relationship. Alex and Maggie disagree about a car crash survivor. Dana is forced to treat an injured motorcyclist. Zach bothers Maggie about dating.

After Charlie’s hand moved in the last episode, Alex has high hopes for his recovery, while she treats a patient who already has multiple surgeries under his belt. Meanwhile, Charlie coaches a young man killed in a roofing accident who has unfinished business with his severely injured brother.

A sleep-deprived Alex takes on a night shift in the ER where an all-star hockey enforcer may be skating full-speed towards an early death. Meanwhile, Charlie meets a suburban punk who is facing the biggest fight of his life.

Charlie tries to save the arm of a man thrown from a horse. Alex joins Manny off-site to help a runaway. A rival from Dev's past arrives at Hope Zion.

Alex Reid treats a young boy with mysterious symptoms while dealing with the arrival of Charlie's ex-wife. Elsewhere in the hospital, Joel Goran and Maggie Lin try to help a patient who refuses life-saving treatment on religious grounds.

A high profile double hand replantation becomes Alex's (Durance) chance to prove to Kinney (Wendy Crewson) that she is still capable of being Chief Surgical Resident. In the ICU, Maggie (Ross) believes a homeless man may have been misdiagnosed.

A routine surgical procedure goes awry when Alex's patient, a soon-to-be-wed young woman, falls into a coma. While Alex struggles with a case that hits close to home, Joel treats a patient who does his own body modifications, and Charlie finds himself drawn to Alex's coma patient in the spirit world.

Alex and Charlie perform a double surgery on a teenage girl; Joel works at the clinic; Maggie must pull through when she is reunited with the Zarb family.

Alex and Maggie ask Charlie for his opinion on a patient's treatment. Zach is persuaded by a patient while transitioning the ER to an urgent care facility.

When Joel gets cold feet in the OR, Kinney takes him with her on a Continuing Medical Education assignment in her hometown to help clear his head. During their field trip, a woman gets pinned underneath a truck and Joel and Kinney lead the rescue effort. Meanwhile, Charlie meets a newly deceased therapist who suspects it’s an emotional block that is keeping him in his coma. Encouraged by Charlie breathing on his own, Alex continues her rounds and diagnoses a fitness buff with a rare condition.

When Alex is forced to put a patient’s gender reassignment surgery on hold, she discovers a secret in his medical history that could save his surgery, but tear his life apart. Charlie deals with a patient who is healthy, sane – and convinced she is going to die at midnight. Meanwhile, Joel secretly helps Sonja deal with a patient of hers who’s been admitted to Hope Zion Hospital.

Shahir and Alex attempt a radical surgery on an Alzheimer's patient; Tom discovers his mentor is keeping a secret; Charlie is torn between Dawn's wishes and the final requests of a dead con-man.

Alex struggles with being a mom, a surgeon and now mentoring a junior resident.

Alex tries to convince Shahir to use an aggressive treatment on a brain tumor patient.

Alex is challenged about the value of holistic medicine. Charlie's abilities are questioned. Two filmmakers go to Hope Zion Hospital.

With Charlie's life hanging in the balance, Alex and Dawn go head-to-head over who gets to be his legal decision maker - but are forced to put personal matters aside when they scrub into a heart transplant surgery together. Charlie, meanwhile, is in no mood to talk to the heart donor - a deceased prisoner.

Charlie’s ex-wife, Dawn, has pulled the plug on his ventilator. All that’s left now is to wait for his breathing to stop. Devastated, Alex vows to stay by Charlie’s side. Meanwhile, Charlie – resisting his death – bumps into Mack MacIlreath, a recently deceased colleague, who has come to help Charlie die. Alex decides to lawyer up and appeal to the Consent & Capacity Board. While the process gets started, Alex is pulled away to meet with a patient: a young woman named Bea, who Alex performed surgery on while working as a first year surgical resident under Dr. Charles Harris. Bea’s check-up is all clear, but Mack and Charlie fear that she was misdiagnosed. And if Alex doesn’t catch it before Bea walks out of the hospital, she could die. Elsewhere, Joel’s hand is broken and he cannot operate until it is fully healed. Stuck with doing consults, he takes the case of a choir singer who makes a “miraculous” recovery from her paralysis.

Two patients need the same heart; a patient has never-before-seen orthopaedic hardware; Dr. Maggie Lin feels the pressure of the upcoming boards.

Dr. Alex Reid puts her reputation on the line when she questions a senior surgeon’s methods.

Alex tracks down the father of a patient who needs a liver transplant. The new CEO of Hope Zion is at odds with Dawn. Zach faces trials in the E.R.

Alex tries to help patient who hurt himself breaking into a house. A friend of Dr. Dev Sekara has been beaten by the police; a heart patient wishes to open an animal sanctuary.

Alex has to put her concerns for Charlie aside when a chance to perform a cancer surgery arises.

When a severely injured man under the spell of hypnosis can't remember his identity, the hypnotist who put him under is called into the hospital - where he uses his psychic ability to connect Charlie and Alex.