Lorcan's sister Alice, who's back using drugs again, begs Lorcan to help her go 'cold turkey'. Although Lorcan knows it's ethically inadvisable to treat his own sister, he reluctantly agrees to help Alice - on condition that she be locked in the flat. No-one at The Clinic can find out what they are up to. Lorcan is so preoccupied with keeping the whole thing quite that he prescribes the wrong medication to a patient with almost disastrous results, not to mention what happens when Alice collapses at the reception desk.

Dan is back with a second chance after surgery but his life is thrown into turmoil when he discovers Cathy is pregnant. It's a tumultuous start for the couple but they finally come together as one and look forward to their future. Cathy is now monitoring Clodagh's every step after her potentially life-threatening diagnosis and this causes tension for Clodagh. Daisy moves in with Conor and starts a relationship with Adam.

Liam's son Ian wants the morning after pill for a girl he had unprotected sex with but, when Liam calls her parents, he is stunned to hear that she claims Ian raped her. Meanwhile, Keelin returns to The Clinic from the U.S. a married woman. Julia's ex Harry arrives back on the scene and Ed changes his mind about selling his half of the building to Cathy and puts it on the market.

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Daisy's close friendship with Conor seems increasingly difficult for Adam to accept. But how will Daisy react when Conor admits that he is in love with her? Meanwhile, Cara marks some notes in the petty-cash box with nail polish to get to the bottom of who is stealing the cash. Elsewhere, Dan has another run-in with new doctor, Lorcan, over one of his methadone patients. Paul discovers he has Peripheral Arterial Disease (PAD) - a clogging of the arteries that could cause a heart attach at any time - a diagnosis that causes dis-harmony in Ronan and Keelin's ...

Julia is tempted by her ex-husband Harry's overtures to win her back - until she discovers that he has cancer. Dr. Lorcan O'Brien buys Ed's half of the practice and building which annoys Dan. Dan finally goes back to work at the Vico and repairs a knife wound scar on Keith Reid.

Daisy and Cara vie for the position of Practice Manager, while two suitors - Conor and Adam - compete for Daisy's affections. Meanwhile, Dan has an uncomfortable run-in with Emer - his nearly one-night stand - outside the Clinic and finds out that she is one of Lorcan's free-clinic patients. Elsewhere, Patrick asks Bernie to move in with him.

Liam dramatically kicks Cara out of the house when he finds out that she gave his son Ian's girlfriend Lucy the morning-after pill. Clodagh and Keelin are not on speaking terms because of Paul Dunne's legal action against Clodagh. Meanwhile, Cathy diagnosis Cara's friend Mary with clinical bulimia. Elsewhere, Aine is accused of taking petty cash causing her to step down as practice manager. Lorcan eventually finds out that the petty-cash culprit is actually his sister Alice who is back using again.

Clodagh's birth mother Carol comes to see her with news that her husband Tom is on the warpath and looking for Clodagh's father, Frederick - the man he believes to be responsible for ruining his life. Upset, Clodagh turns Carol away but later at The Clinic Tom shows up and won't leave until Clodagh hears him out. He becomes physically threatening and Lorcan has to step in to remove him from the premises. Carol returns to beg the shaken Clodagh not to get the Gardaí involved and, while Clodagh agrees to this request, she decides its best not to talk to Carol anymore.

It's Ed's birthday and the day starts off with him catching a junkie breaking into the surgery. Mrs Fleming is rattled by the burglary as the boy gained access through her flat.

Today is the anniversary of the day Cathy gave birth to a stillborn baby. Cathy and Ed's grief is private so much so they can't even talk to each other about it. Very few people at the Clinic know about the stillbirth.

Keelin has to face up to the news about her mother's cancer. She realises that her family cannot cope and she has to give up her single lifestyle and move back home to care for Mary, a difficult woman whom Keelin has never got on with at the best of times. Fiona goes further off the rails, and Cathy is forced to dismiss her.

Alex considers starting a thing with local barman, Michael. His carefree existence is abruptly shattered however by a needle stick incident. The thought of contracting Hep C from the needle and having to give up the job he loves turns Alex into an unrecognisable nervous wreck, much to everyone's surprise.

Susie's life is changed totally with the unexpected arrival of her teenage daughter Moya, who has decided to leave her home with Susie's parents and move in with her mother.

Dan becomes increasingly reliant on his drug habit. He turns to Susie for help but she calls him a coward. Patrick meets Sean's mother Ann Connell and a family secret is revealed. The staff attends a hospital party and Daisy gives Brendan a makeover, with startling results.

Patrick's long-running case with Seán, plus his constant work load, takes its toll on his own mental health. In addition he has to face Seán's father who resents the disruption caused to his family life by the disclosure of the secret. The usually calm Patrick shocks everyone by his behaviour.

Cathy and Ed attend Mary's funeral. The event gives them a chance to talk about their own grief over the baby. Back at the clinic, confusion reigns while the doctors are away. Mrs Fleming finally understands the truth about Fiona and apologises to Cathy and Ed for misjudging them.

Dan returns to Dublin and looks to make up with Susie, but soon discovers she has gone to Thailand. Cathy prescribes penicillin to a patient, not knowing the serious effect the drug will have on them.

Clodagh, the new GP, has a bad start to her day when she knocks Ed over. Her day goes from bad to worse when she suspects a patient has an ectopic pregnancy, but is overruled by Cathy's father, Mr O'Callaghan.

Brendan takes his grandmother home from hospital after she confesses that she knows she is dying, but wants to do so in her own bed.

Things are hotting up as affairs start rising to the surface. Paul tells Keelin he knows about her and Ed and begs her not to say anything to Yvonne about his carry on at the stag party. Meanwhile, Cathy tells Ed she might be pregnant and in turn Ed tells Keelin the news, who lets a congratulations slip to Cathy! Meanwhile, Yvonne hears Keelin and Paul fighting about his stag night antics and loses her temper with Keelin and tells her she doesn't want her to be her bridesmaid any more.

Dermot asks Fiona to join him for lunch. Cathy is interested in buying next door and goes to her Dad in the hope of interesting him in investing.

Ed finds Cathy's pills in her drawer and concludes that they have different ideas about wanting a family. Cathy visits the bank and realises that they will have to let staff go if they are to service the loan that she hopes to get to cover her dad's share.

Ed wakes up in Patrick's flat. He walks home, hungover and meets Cathy out for a run but she ignores him. Cathy confides in Áine that she and Ed are having problems.

Cathy wakes up to see Dan in the next room and wonders what happened the night before. Ed meanwhile wakes up at Patrick's who tells him that he should go home. Dan sees a former patient of Ed's for a cosmetic consultation and suspects she has a thyroid problem.