Daisy has fallen hook, line and sinker for Will, along with his drinking, drugs and fast living. They spend the night together in Cathy's flat. Will refuses to get up and come to work the next day, much to Daisy's dismay.

Dan is terrified when he realises he could be caught out for dating both Cathy and Sinéad and tries to find a way to prevent them meeting. Dan is thwarted when Sinéad meets Cathy. He tries to talk his way out of it by telling Cathy it was her idea to have a no strings attached relationship and as soon as they started to get serious he finished with Sinéad.

Alex is shaken when he bumps into an old friend at a club, who calls him Chris. Alex tells the guy to get lost claiming he doesn't know who he is and walks off with Sam in tow. Alex and Sam argue later at home. Sam thinks Alex has been picking up other men calling himself by a different name.

Patrick is lonely and everything around him is further illustrating how alone he is. Through a chance encounter with an old acquaintance, he learns that his ex-wife Lisa is in town. They arrange to meet. Lisa hasn't seen him sober in a long time and is surprised by this new man. They get on great, the sparks are flying and their relationship takes a new turn.

Clodagh gets some shocking news, her father had an affair and she was the product of it. Daisy takes a fancy to Brendan's replacement, Will Cafferty. Cathy & Dan's relationship develops further.

Keelin has to decide if her business is worth losing her friends. Paul turns up at the Clinic asking Keelin to build bridges with a pregnant Kathleen, she is sceptical at first but is delighted when she arranges dinner with Kathleen. Keelin is furious to learn that Cathy has been referring patients to other physiotherapists.

Mr O'Callaghan's demise is revealed as he plummets from the high of the nomination for his Presidency to the depths of despair when he loses out. He is unable to take any more or to reach out to anybody, most notably Cathy

Richard is struggling to deal with his wife Annie's illness while trying to keep his home and work life separate. His daughter Flossie is devastated when she discovers that she could have the Huntington's gene. Trying to pretend that everything is okay and not accepting help has not worked, Richard finally comes to the realisation that he has to face up to his wife's illness.

Keelin has to face up to the news about her mother's cancer. She realises that her family cannot cope and she has to give up her single lifestyle and move back home to care for Mary, a difficult woman whom Keelin has never got on with at the best of times. Fiona goes further off the rails, and Cathy is forced to dismiss her.

Susie's life is changed totally with the unexpected arrival of her teenage daughter Moya, who has decided to leave her home with Susie's parents and move in with her mother.

Patrick's long-running case with Seán, plus his constant work load, takes its toll on his own mental health. In addition he has to face Seán's father who resents the disruption caused to his family life by the disclosure of the secret. The usually calm Patrick shocks everyone by his behaviour.

Alex considers starting a thing with local barman, Michael. His carefree existence is abruptly shattered however by a needle stick incident. The thought of contracting Hep C from the needle and having to give up the job he loves turns Alex into an unrecognisable nervous wreck, much to everyone's surprise.

Cathy and Ed attend Mary's funeral. The event gives them a chance to talk about their own grief over the baby. Back at the clinic, confusion reigns while the doctors are away. Mrs Fleming finally understands the truth about Fiona and apologises to Cathy and Ed for misjudging them.

Dan becomes increasingly reliant on his drug habit. He turns to Susie for help but she calls him a coward. Patrick meets Sean's mother Ann Connell and a family secret is revealed. The staff attends a hospital party and Daisy gives Brendan a makeover, with startling results.

Brendan's inheritance of his Nan's house worth 2.75 million euro has just become official. The other staff in The Clinic question Brendan on what he would like to do with this money. Brendan is happy with his life and has no intention of selling his beloved Nan's house. Everybody has an ambition except for him and he tries to live his ambition through Clodagh.

Fiona is deeply missing Ed and thinks that The Clinic is falling apart without him. In her attempts to save The Clinic she only manages to make matters worse. Cathy too is feeling the aftermath of Ed's departure and is unable to cope with the daily business.

Today is the anniversary of the day Cathy gave birth to a stillborn baby. Cathy and Ed's grief is private so much so they can't even talk to each other about it. Very few people at the Clinic know about the stillbirth.

It's Ed's birthday and the day starts off with him catching a junkie breaking into the surgery. Mrs Fleming is rattled by the burglary as the boy gained access through her flat.

Dan returns to Dublin and looks to make up with Susie, but soon discovers she has gone to Thailand. Cathy prescribes penicillin to a patient, not knowing the serious effect the drug will have on them.

Clodagh, the new GP, has a bad start to her day when she knocks Ed over. Her day goes from bad to worse when she suspects a patient has an ectopic pregnancy, but is overruled by Cathy's father, Mr O'Callaghan.

Brendan takes his grandmother home from hospital after she confesses that she knows she is dying, but wants to do so in her own bed.

Things are hotting up as affairs start rising to the surface. Paul tells Keelin he knows about her and Ed and begs her not to say anything to Yvonne about his carry on at the stag party. Meanwhile, Cathy tells Ed she might be pregnant and in turn Ed tells Keelin the news, who lets a congratulations slip to Cathy! Meanwhile, Yvonne hears Keelin and Paul fighting about his stag night antics and loses her temper with Keelin and tells her she doesn't want her to be her bridesmaid any more.

Dermot asks Fiona to join him for lunch. Cathy is interested in buying next door and goes to her Dad in the hope of interesting him in investing.

Ed finds Cathy's pills in her drawer and concludes that they have different ideas about wanting a family. Cathy visits the bank and realises that they will have to let staff go if they are to service the loan that she hopes to get to cover her dad's share.

Ed wakes up in Patrick's flat. He walks home, hungover and meets Cathy out for a run but she ignores him. Cathy confides in Áine that she and Ed are having problems.