Dan returns to Dublin and looks to make up with Susie, but soon discovers she has gone to Thailand. Cathy prescribes penicillin to a patient, not knowing the serious effect the drug will have on them.

Clodagh, the new GP, has a bad start to her day when she knocks Ed over. Her day goes from bad to worse when she suspects a patient has an ectopic pregnancy, but is overruled by Cathy's father, Mr O'Callaghan.

Brendan takes his grandmother home from hospital after she confesses that she knows she is dying, but wants to do so in her own bed.

Things are hotting up as affairs start rising to the surface. Paul tells Keelin he knows about her and Ed and begs her not to say anything to Yvonne about his carry on at the stag party. Meanwhile, Cathy tells Ed she might be pregnant and in turn Ed tells Keelin the news, who lets a congratulations slip to Cathy! Meanwhile, Yvonne hears Keelin and Paul fighting about his stag night antics and loses her temper with Keelin and tells her she doesn't want her to be her bridesmaid any more.

Dermot asks Fiona to join him for lunch. Cathy is interested in buying next door and goes to her Dad in the hope of interesting him in investing.

Ed finds Cathy's pills in her drawer and concludes that they have different ideas about wanting a family. Cathy visits the bank and realises that they will have to let staff go if they are to service the loan that she hopes to get to cover her dad's share.

Ed wakes up in Patrick's flat. He walks home, hungover and meets Cathy out for a run but she ignores him. Cathy confides in Áine that she and Ed are having problems.

Cathy wakes up to see Dan in the next room and wonders what happened the night before. Ed meanwhile wakes up at Patrick's who tells him that he should go home. Dan sees a former patient of Ed's for a cosmetic consultation and suspects she has a thyroid problem.

Cathy is confident that she'll finally be able to oust her manipulative business partner and ex-lover, Dan. But her plan backfires when she discovers that her late father bequeathed his stake in the clinic to his secret partner of five years, Dr. Julia Brady.

Aine finds it increasingly difficult to cope with her son Tommy and reacts in a shocking and distressing way. Meanwhile, Cathy deliberately keeps Julia waiting in reception for their meeting. This backfires on Cathy when Dan invites Julia to dinner and sweet-talks her into taking a more permanent position in the Clinic.

The clinic's new nurse, Liam Smith, has a disastrous first day - and worst of all, he gets Dan's back up when he talks one of his patients out of getting rhinoplasty.

Keelin calls off her wedding to Ronan after an argument, while Cathy and Julia clash over Julia's bedside manner. Sinead is diagnosed with endometriosis and Dan collapses after a squash game.

Dan is devastated to discover he has a life-threatening and that the only operation that can cure him may also end his career. He tries to confide his problems to Cathy, but she tells him there is just too much water under the bridge now for them to be friends. Meanwhile, Keelin, with the help of her father, decides to follow Ronan to New York to give their relationship a second chance.

Clodagh makes the decision to reveal her true identity to her birth mother Carol. What Clodagh hasn't taken into account is whether or not the news will be well received.

Patrick refuses to take an agitated Conor for a session after Conor is rude and insults Bernie. Clodagh has had enough with her acupuncture patients and tells Julia she would like to concentrate on her general practice. Daisy is clearly uncomfortable around Jack and calls him a creep under her breath. Cathy is puzzled by the way Dan is acting and agrees to meet him for lunch. Liam teaches his son, Ian, a lesson after he had a few beers and fell over drunk. Ann Marie teases Jack about Clodagh fancying him but Jack tells her she has nothing to worry about.

Daisy thinks she may have been a cause of Conor's break up with his girlfriend, Siobhann, as well as his accident, after Siobhann warns Daisy to stay away from him. Cara tells Daisy that she didn't give Conor the wrong signals. Patrick reassures Daisy she's not to blame for what happened with Conor and needs to talk to him. Daisy talks to Conor and is relieved his self harming had nothing to do with her.

Jack creates a scene in the clinic after finding out that Daisy has accused him of sexual harassment.

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Dan is back with a second chance after surgery but his life is thrown into turmoil when he discovers Cathy is pregnant. It's a tumultuous start for the couple but they finally come together as one and look forward to their future. Cathy is now monitoring Clodagh's every step after her potentially life-threatening diagnosis and this causes tension for Clodagh. Daisy moves in with Conor and starts a relationship with Adam.

Liam's son Ian wants the morning after pill for a girl he had unprotected sex with but, when Liam calls her parents, he is stunned to hear that she claims Ian raped her. Meanwhile, Keelin returns to The Clinic from the U.S. a married woman. Julia's ex Harry arrives back on the scene and Ed changes his mind about selling his half of the building to Cathy and puts it on the market.

Julia is tempted by her ex-husband Harry's overtures to win her back - until she discovers that he has cancer. Dr. Lorcan O'Brien buys Ed's half of the practice and building which annoys Dan. Dan finally goes back to work at the Vico and repairs a knife wound scar on Keith Reid.

Clodagh's birth mother Carol comes to see her with news that her husband Tom is on the warpath and looking for Clodagh's father, Frederick - the man he believes to be responsible for ruining his life. Upset, Clodagh turns Carol away but later at The Clinic Tom shows up and won't leave until Clodagh hears him out. He becomes physically threatening and Lorcan has to step in to remove him from the premises. Carol returns to beg the shaken Clodagh not to get the Gardaí involved and, while Clodagh agrees to this request, she decides its best not to talk to Carol anymore.

Daisy's close friendship with Conor seems increasingly difficult for Adam to accept. But how will Daisy react when Conor admits that he is in love with her? Meanwhile, Cara marks some notes in the petty-cash box with nail polish to get to the bottom of who is stealing the cash. Elsewhere, Dan has another run-in with new doctor, Lorcan, over one of his methadone patients. Paul discovers he has Peripheral Arterial Disease (PAD) - a clogging of the arteries that could cause a heart attach at any time - a diagnosis that causes dis-harmony in Ronan and Keelin's ...

Liam dramatically kicks Cara out of the house when he finds out that she gave his son Ian's girlfriend Lucy the morning-after pill. Clodagh and Keelin are not on speaking terms because of Paul Dunne's legal action against Clodagh. Meanwhile, Cathy diagnosis Cara's friend Mary with clinical bulimia. Elsewhere, Aine is accused of taking petty cash causing her to step down as practice manager. Lorcan eventually finds out that the petty-cash culprit is actually his sister Alice who is back using again.

Daisy and Cara vie for the position of Practice Manager, while two suitors - Conor and Adam - compete for Daisy's affections. Meanwhile, Dan has an uncomfortable run-in with Emer - his nearly one-night stand - outside the Clinic and finds out that she is one of Lorcan's free-clinic patients. Elsewhere, Patrick asks Bernie to move in with him.