Bernie moves in with Patrick, but she soon realises that he isn't ready to co-habit. Meanwhile, new practice manager Cara struggles to cope without a receptionist and Kieran cannot cope without Molly and leaves baby Hope with Cathy. Elsewhere, Dan and Cathy look at a property in the country and Emer has delusions over her relationship with Dan.

Clodagh's birth mother Carol comes to see her with news that her husband Tom is on the warpath and looking for Clodagh's father, Frederick - the man he believes to be responsible for ruining his life. Upset, Clodagh turns Carol away but later at The Clinic Tom shows up and won't leave until Clodagh hears him out. He becomes physically threatening and Lorcan has to step in to remove him from the premises. Carol returns to beg the shaken Clodagh not to get the Gardaí involved and, while Clodagh agrees to this request, she decides its best not to talk to Carol anymore.

Having had his advances turned down by Daisy and having broken up with Alice Dan turns to gambling and meets the mysterious Lucille. Ruairi and Daisy become closer as they paint the clinic's conservatory. Lorcan is brought further under the influence of Dave and ends up dealing with a known drug dealer to get methadone for him. Clodagh's first stint as a medical radio D.J. marks an eventful time for her and a patient she deals with online. Meanwhile, new doctor Dr. Edel Swift has major plans for the clinic, Alice quits as nurse in the practice and Grace has to deal ...

Dan's last day at the Clarence Street Clinic is anything but uneventful as his nemesis Diarmuid and Lucille arrive at his surgery and demand that he treat a bullet wound that Lucille has received. When things don't go Diarmuid's way he takes the Clinic staff hostage and makes Dan and Edel operate under gunpoint. When Daisy argues with him he hits her forcing Ruairi to attack him which results in Diarmuid shooting him in the stomach. Daisy begs Dan to help Ruairi and although under threat of being shot he brings Ruairi outside and calls an ambulance as the Gardai storm...

Liam dramatically kicks Cara out of the house when he finds out that she gave his son Ian's girlfriend Lucy the morning-after pill. Clodagh and Keelin are not on speaking terms because of Paul Dunne's legal action against Clodagh. Meanwhile, Cathy diagnosis Cara's friend Mary with clinical bulimia. Elsewhere, Aine is accused of taking petty cash causing her to step down as practice manager. Lorcan eventually finds out that the petty-cash culprit is actually his sister Alice who is back using again.

Jack creates a scene in the clinic after finding out that Daisy has accused him of sexual harassment.

Julia is tempted by her ex-husband Harry's overtures to win her back - until she discovers that he has cancer. Dr. Lorcan O'Brien buys Ed's half of the practice and building which annoys Dan. Dan finally goes back to work at the Vico and repairs a knife wound scar on Keith Reid.

Daisy and Cara vie for the position of Practice Manager, while two suitors - Conor and Adam - compete for Daisy's affections. Meanwhile, Dan has an uncomfortable run-in with Emer - his nearly one-night stand - outside the Clinic and finds out that she is one of Lorcan's free-clinic patients. Elsewhere, Patrick asks Bernie to move in with him.

Clodagh makes the decision to reveal her true identity to her birth mother Carol. What Clodagh hasn't taken into account is whether or not the news will be well received.

Daisy starts monitoring the Clinic's cash-flow and is less than happy with her findings. Dan takes on the complicated surgery of a young African boy with a deformity that could kill him. Ruairí's dad Franny goes to see Patrick and he encourages him to enjoy his last few months by drawing up a 'bucket list'. Meanwhile, Cara forges a prescription for a long-standing patient but is found out leaving Daisy with no option but to give her a verbal warning. Elsewhere, Dave blackmails Lorcan to giving him cash in return for him staying silent on his HIV status.

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Daisy's close friendship with Conor seems increasingly difficult for Adam to accept. But how will Daisy react when Conor admits that he is in love with her? Meanwhile, Cara marks some notes in the petty-cash box with nail polish to get to the bottom of who is stealing the cash. Elsewhere, Dan has another run-in with new doctor, Lorcan, over one of his methadone patients. Paul discovers he has Peripheral Arterial Disease (PAD) - a clogging of the arteries that could cause a heart attach at any time - a diagnosis that causes dis-harmony in Ronan and Keelin's ...

Aine finds it increasingly difficult to cope with her son Tommy and reacts in a shocking and distressing way. Meanwhile, Cathy deliberately keeps Julia waiting in reception for their meeting. This backfires on Cathy when Dan invites Julia to dinner and sweet-talks her into taking a more permanent position in the Clinic.

Rumour and speculation spread like wildfire about The Clinic's HIV-infected doctor causing cancellations and panic. Lorcan disappears and it is up to Clodagh to tell Madison about her dad's condition before she hears about it from others - she takes the news badly but in the end she and Clodagh track Lorcan down. Dan tells Daisy that he and Cathy knew of Lorcan's HIV status and asks now that they take action and have him removed from the Clinic before the practice goes under. Dan performs a double mastectomy on a young woman whose family has a chronic history of ...

It's Ed's birthday and the day starts off with him catching a junkie breaking into the surgery. Mrs Fleming is rattled by the burglary as the boy gained access through her flat.

Dan is devastated to discover he has a life-threatening and that the only operation that can cure him may also end his career. He tries to confide his problems to Cathy, but she tells him there is just too much water under the bridge now for them to be friends. Meanwhile, Keelin, with the help of her father, decides to follow Ronan to New York to give their relationship a second chance.

Daisy thinks she may have been a cause of Conor's break up with his girlfriend, Siobhann, as well as his accident, after Siobhann warns Daisy to stay away from him. Cara tells Daisy that she didn't give Conor the wrong signals. Patrick reassures Daisy she's not to blame for what happened with Conor and needs to talk to him. Daisy talks to Conor and is relieved his self harming had nothing to do with her.

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Ruairi's dad Franny's condition deteriorates faster and after seeing his old friend Al in the early stages of dementia asks Grace to up his morphine to ease his symptoms so that he doesn't have to depend on Ruairi and Terry. Madison develops a crush on Fergus. Dave continues to use his knowledge of Lorcan's HIV status to get preferential treatment. Meanwhile, Alice becomes jealous of Dan's attention to Daisy. Elsewhere, a striking blonde visiting the Clinic arouses Dan's curiosity. Franny dies in his wife's arms after his big party and Ruairi discovers afterwards that...

Today is the anniversary of the day Cathy gave birth to a stillborn baby. Cathy and Ed's grief is private so much so they can't even talk to each other about it. Very few people at the Clinic know about the stillbirth.

Keelin calls off her wedding to Ronan after an argument, while Cathy and Julia clash over Julia's bedside manner. Sinead is diagnosed with endometriosis and Dan collapses after a squash game.

New general surgery doctor Edel Swift deals with a litany of emergencies that walk into the Clarence Street Clinic and Dan is quite taken by her but he is also obsessed with Lucille and even more so when he finds he cheated at poker and she now owns his shares. Elsewhere, Lorcan finds out that Annie has tested positive for HIV and has to break the news to her but the stress of it makes him take it out on Clodagh. As a result of Annie's test Dave turns up and threatens him again with exposure but Clodagh intervenes and tells Dave that he also is HIV and she had him ...

Fiona is deeply missing Ed and thinks that The Clinic is falling apart without him. In her attempts to save The Clinic she only manages to make matters worse. Cathy too is feeling the aftermath of Ed's departure and is unable to cope with the daily business.

Cathy is confident that she'll finally be able to oust her manipulative business partner and ex-lover, Dan. But her plan backfires when she discovers that her late father bequeathed his stake in the clinic to his secret partner of five years, Dr. Julia Brady.

Dan is questioned by the Gardai over Niall Boylan's death but is eventually released only to incur the wrath of Daisy about his involvement in supplying cosmetic surgery products at inflated prices. Lorcan supports Dan which Daisy doesn't understand but Dan is holding a trump card - Lorcan's HIV status. Elsewhere, Lorcan's daughter Madison moves in with him.