Lim is challenged by the unique circumstances surrounding a pregnant patient with an aggressive tumor. Elsewhere, after misdiagnosing a patient, Claire makes a disconcerting discovery about certain practices at the hospital.

Drs. Lim, Park and Wolke treat a woman with Valley fever and discover a secret she has been hiding from her fiancé. Meanwhile, Drs. Murphy, Allen and Andrews treat a 45-year-old virgin and help her make a big decision about her life.

With several candidates vying for residency at St. Bonaventure, Chief of Surgery Dr. Audrey Lim tasks Dr. Shaun Murphy, Dr. Claire Browne and Dr. Alex Park with mentoring the top first-year resident contenders. As their mentees shadow them for the day, Shaun and Park meet with Andrews to discuss a difficult surgery scheduled for a minor. Later, Shaun inadvertently insults Lea while discussing the pros and cons of the controversial surgery. And elsewhere, Dr. Morgan Reznick seeks out Claire and Lim’s help on a consult.

Dr. Shaun Murphy is surprised to learn that his young cancer patient identifies as a girl while being biologically male. Shaun must quickly learn to understand his patient, her medical needs and how to work with her family, who all feel they know what is best for her.

While Doctor Andrews treats a foster kid for injuries sustained at his group home, Shaun and team look to Lea's expertise with cars and auto repair to help a patient whose iron lung has broken. Meanwhile, the patient's niece, a documentarian, takes an interest in Shaun.

Asher's views on the construct of marriage complicate his future with Jerome. Meanwhile, Asher also briefly revisits his religious past to aid a patient's conversion to Judaism for his fiancée.

Dr. Murphy treats a patient who has an illness that is not only unpredictable in nature, but also unlike anything he or the team has seen before. Dr. Claire Brown continues to work through her grief, still reeling from Dr. Neil Melendez's death.

Shaun and Lea go on a camping trip to distract themselves from their grief over their miscarriage. Meanwhile, Morgan and Park argue about the best course of treatment for their patient.

Dr. Shaun Murphy's teenage patient has been confined to her home her entire life due to a rare heart condition. Despite her condition, she has cultivated a large group of friends online and hopes that the surgical team can find a way to give her the life she has always dreamed of having. Meanwhile, a young patient's perfectly matched organ donor is causing a moral dilemma for the parents and the patient.

Shaun has a hard time balancing his fears and concerns about potentially jeopardizing Lea's health and wanting to be with the woman he loves. Claire looks for a way to grieve Melendez's death. Park and Mia discuss their future together.

As Chief of Surgery Dr. Audrey Lim struggles to cope with the residual emotional trauma of COVID-19, she encounters a young war veteran fighting debilitating PTSD. After discussing his case with the team, Dr. Claire Browne suggests a radical treatment to help him. Meanwhile, still reeling from the recent loss of his mentee’s patient, Dr. Shaun Murphy declares he doesn’t want to teach the new residents anymore. And elsewhere, an eccentric patient keeps the team entertained.

Claire is blindsided when her absentee father shows up at her door. Meanwhile, Shaun feels disconnected from Lea, causing tension in their relationship.

After finding out the gender of their unborn child, Lea's enthusiasm prompts Shaun to make an effort to be a more supportive partner. Meanwhile, the team treats a navy pilot whose previous doctor's misdiagnosis compromises her chances at a full recovery.

While Drs. Lim, Murphy and Wolke help a teenage “biohacker” whose self- experiments begin to compromise his health, Drs. Morgan, Park, Jordan and Glassman treat a young woman who wants a controversial surgery to treat her depression and chronic pain. Additionally, Dr. Reznick looks to take the next step in her relationship with Dr. Park.

Sophie takes Lea out for a day full of luxurious wedding planning. And after a near fatal oversight, Dr. Lim senses an underlying issue is behind nurse Villanueva's unprofessional behavior.

Dr. Shaun Murphy must learn how to work with Dr. Jared Kalu again and remind him that he must start all over at St. Bonaventure. Meanwhile, Dr. Murphy treats a teenager suffering from neurological problems with a very high-risk procedure.

Dr. Shaun Murphy suspects his patient is lying about the reason for her injury and makes a controversial assumption about her motives. Meanwhile, Dr. Neil Melendez’s personal life could be affecting his work and, ultimately, his patients lives.

Dr. Morgan Reznik and Dr. Shaun Murphy's pregnant patient with twins is having pain and they are forced to grapple with a decision no one wants to make. Meanwhile, Shaun asks Lea to move back in despite her reservations

Dr. Morgan Reznick discovers her patient’s wealth and obsession with extending his life is a dangerous mix that could end up costing more than he can afford.

When the hospital is hit with a cyberattack threatening to shut down life-saving machines, Lea rises to the challenge and looks to outsmart the hackers to prove herself. Meanwhile, the team treats an inspirational cancer survivor-turned-successful-philanthropist who harbors a dark secret.

Dr. Shaun Murphy and the team race to save a pregnant woman's baby and find her current situation as a convicted felon complicates it even more than they realize. Meanwhile, the hospital takes on some unexpected changes that the staff are not prepared for.

Dr. Park and Dr. Murphy treat an elderly Asian man brought to St. Bonaventure by his daughter after being the victim of a hate crime. In addition, Lea goes behind Shaun’s back to help raise his negative patient satisfaction scores.

Now that Shaun has called off the wedding, he is forced to confront Lea about their relationship and determine what he really means to her. Meanwhile, the team debate their opinions on plastic surgery and Dr. Audrey Lim hopes to expose Salen’s cover-up over an infant’s death to take her down before it is too late.

In the midst of a heatwave, Dr. Shaun Murphy and Dr. Danica Powell are at odds when it comes to their patient’s surgery. Their heated stalemate tests Shaun’s patience and his willingness to compromise. Meanwhile, when the hospital loses power, Lea and Dr. Aaron Glassman are forced to come up with a quick solution or risk a total shutdown that could risk patients’ lives on the 100th episode.

Shaun is ready for the next step in his relationship with Carly; however, he continues to struggle as they grow closer and more intimate, and is dealt some troubling news about a deeply personal issue. Meanwhile, a young patient must decide on a treatment that could save her life or possibly destroy her marriage.