The team considers if a father who cleans crime scenes for a living led to his disappearance with his daughter.

When a college student disappears after making racial remarks in a class, the team wonders if those may be directly connected to his disappearance.

The four-year-old adopted son of a celebrity couple is kidnapped, and the team must determine if the reason has to deal with the parents' status or the boy's own Sudanese origin.

The team searches for a missing mother who they believe may be searching for her son, who is also missing.

The disappearance of an ultimate fighter leads the team to investigate his background, where they learn the man had a number of enemies.

When a woman disappears after her boyfriend is killed by the police, the team suspects gang involvement. Later, Sam learns she's pregnant.

An office shooting forces a woman to disappear, possibly to hide a deep secret.

Malone and his team start off the new year investigating how a private investigator might have went missing.

Jack goes missing after taking a case into his own hands which soon becomes intertwined with a human trafficking prostitution case that Vivian is working on.

The team determines if an ex-con's past criminal activity caused her to disappear after visiting a prison inmate. Det. Mars and Agent Johnson also continue their investigation.

A child prodigy turned store Santa vanishes and the team wonders if he had criminal connections.

After the latest lottery winner goes missing, the team works to figure out why.

The team work on a case where a veterans-hospital worker vanishes and have two leads.

While struggling to deal with the aftermath of Jack's accident, the team searches to find a teen heart transplant recipient, believing her disappearance might be connected to her donor. Samantha talks to Brian.

The team searches for a coma patient who had woken up after three years only to disappear.

A truck driver goes missing after saving a boy's life, and the team determines if that has anything to do with his disappearance. Meanwhile, Jack's mental health is examined by a psychiatrist.

Malone's team joins forces with Gil Grissom, a CSI from Las Vegas, and his team as they track a serial killer with ties to New York. The crossover starts on CSI: Crime Scene Investigation S08E06 Who and What (I).

Five people with an odd connection go missing from a coffee shop, and the team determines what the connection had to do with their disappearance. Meanwhile, Samantha gets ready for the birth of her child.