Vivian thinks about her recent surgical problems while searching for a missing woman with a terminal condition.

The team tries to determine whether or not the recent disappearance of an air traffic controller has connections to the Middle East. The team soon learns that his wife died in an automobile accident and he was having an affair with her sister.

John Michaels is a 71-year-old insurance investigator who went missing after last being seen getting into a car with two strange men. While investigating his disappearance, the team finds that he had recently tried to make amends with his ex-wife and has been trying desperately to get his older daughter on the straight and narrow. Things get strange in the case though, and all is not as it seems.

The team searches for missing water plant supervisor Jason Turner, and learn that he had become the target of a lot of anger after recent layoffs at the plant. Carlos comes to the office looking for Elena.

The team must decide whether or not a doctor's past is a factor in her disappearance.

After therapist Gina Hill disappears, the team investigates and initially suspects that one of her patients may be involved. After discussions with Gina's fiancé and her own therapist, the team follows the trail of clues to a bartender named Vince with an unusual ability to get good women to do whatever he wants them to. Martin continues to struggle with his recovery.

Megan Sullivan is H.I.V. positive, pregnant and missing. Initially the team suspects that her husband, who seemed to be less than thrilled about the baby, is involved, but soon learn that Megan had received a call from a prison, and their search tracks them to a former lover, who gave her H.I.V., her husband's former mistress, who had seen her taking part in a tense conversation not long before she vanished, and her own H.I.V. specialist, who had recently given her bad news. Martin thanks Danny for his help, and tells him that he is continuing to seek counseling for his addiction.

The team investigates the disappearance of social worker Eric Hayes, who had given thirty days notice to his job not long before. When their investigation leads them to a young pregnant woman who had already lost one child to the system, the agents begin to believe the disillusioned social worker may have been having an affair but soon discover that he may have been trying to right the wrong that drove him from his job. Danny has trouble with the investigation, as it reminds him of his own experience in foster care. Jack confides in Samantha about his relationship with Ann, but it may be too late.

Barry Rosen goes missing shortly after being poisoned with bleach in a chili eating contest. While investigating Barry's disappearance, the team soon learns that he had been approached to throw the eating contest, and also that he had been spending a lot of time with a local prostitute in an effort to learn how to act around women. Danny is caught in the middle when Carlos asks him for a letter of reference in an upcoming custody review, and Elena informs him that Carlos is actually suing her for sole custody of Sofie. Danny warns Carlos that he is not going to be caught in the middle.

The team searches for Chris Manning, a family court judge with a soft side who went missing after meeting with a young boy caught between his mother and his abusive father. Suspicion initially turns anyone Manning may have riled up due to his court rulings, but after his clerk is shot in what appears to be an attempt on Manning's life, the team learns that the secret behind Manning's disappearance is tied up with something that happened over twenty years earlier.

The team find themselves up against the ropes as multiple mysteries arise in the case of a boxer. Dante Jones disappears moments before a bout with a $500,000 purse that which could have made him a title contender. Jack suspects it's stunt, but Vivian, a Jones fan, can't believe that the charity-loving, straight-arrow fighter would go doewn that low road. The search goes in a new direction when his younger brother who he is always bailing out of trouble, vanishes. Then it's learned he has made 2 million dollers in the past five years,but he only has $6000 in his bank account.

Wendy Kim goes missing during her shift at the family deli, and the team gets involved to find out what happened to the young Korean woman. It isn't long before they learn that Wendy had recently broken off an engagement to a young Korean man her parents were very supportive of, and that she had recently been doing a lot of on-line dating and had gotten herself involved with the wrong kind of men, including one who wouldn't take no for an answer.

Martin brings the team in on the hunt for a young woman that went missing after a priest attempted to exorcise a demon from her. He begins to feel guilty when he finds out he used to work with her, but doesn't remember her.

The team searches for a missing mother who they believe may be searching for her son, who is also missing.

After a young woman named Agnes Deschamps goes missing, the team takes a look into her disappearance and learns that the young woman was believed to be a psychic. Sam has trouble accepting that one of their witnesses purports to be a psychic, although she is thrown when the woman correctly points out her problems with Martin. Jack, Martin and Danny pick up the extra hours with Vivian out awaiting heart surgery and together the team manages to track the young woman down after a supermarket parking lot kidnapping yeilds an unlikely clue.

Max Cassidy vanishes after leaving a message on his wife's voicemail, with both Jack and Ann frantic to find him. While investigating, Jack realises that Max was having an affair, and that he's gotten much deeper into a case than he should have following the murder of his partner, Jimmy, a man Max had felt was too green for undercover work. Both Jack and Ann fear the worst as the team tries to hunt down Max.

The team investigates when a young paramedic with gang ties disappears. Jack and Ann bond over their recent losses.

The team searches for a teenage figure skater who disappears after practice one day and discover that many people in her life had reason to worry. The team's investigation leads to the rink's operator, a convicted rapist who was the last to see the girl.

When 17-year-old Ted Soros goes missing after a basketball game, the team begins an investigation, soon learning that Ted was an emancipated minor who was living on his own to attend a school with an exemplary basketball program. Learning he had recently contacted his mother with a request for legal advice from an uncle, the team begins to suspect that Ted may have done something that he could face criminal charges for, and realise that Ted's secret is connected to a university recruiting party. While the team works Ted's disappearance, Jack learns from Ann that she lost the baby, and waits for her at the clinic while she seeks medical attention.

When a young artist disappears, the team is concerned that one of her subjects may have been unhappy with her work.

When a young, interracial boy goes missing, race and money appear to play the starring roles in the investigation.

A former soldier, now stuntman, goes missing and the team learns that he changed his will only short time before he went missing which makes them wonder who needed the money.

Malone's team joins forces with Gil Grissom, a CSI from Las Vegas, and his team as they track a serial killer with ties to New York. The crossover starts on CSI: Crime Scene Investigation S08E06 Who and What (I).

While struggling to deal with the aftermath of Jack's accident, the team searches to find a teen heart transplant recipient, believing her disappearance might be connected to her donor. Samantha talks to Brian.

The team searches for a coma patient who had woken up after three years only to disappear.