John Michaels is a 71-year-old insurance investigator who went missing after last being seen getting into a car with two strange men. While investigating his disappearance, the team finds that he had recently tried to make amends with his ex-wife and has been trying desperately to get his older daughter on the straight and narrow. Things get strange in the case though, and all is not as it seems.

Sam agrees to do a favor for a friend by looking into the identity of a young amnesiac who was found wearing expensive clothes by two police officers. The investigation leads them to a play the woman was involved in and a mugging gone wrong, then they follow the trail to the woman's past, which seems to have been the trigger for her amnesia. Jack takes some time off work to deal with his father, who is getting worse as his Alzheimers begins to take over and his kidneys fail. Jack finally convinces Frank to seek help, but it's too late, and Jack has to say goodbye to his father.

When Leah Robinson goes missing after a confrontation with a young man at an art gallery, the team mvoes in to investigate and soon become suspicious of Leah, suspecting her of murdering young women that she believed to be involved with her husband, Ken. Ann isn't quite ready to take her romance with Jack public, and their relationship gets rocky when their different methods of handling the case tip off the suspect.

After attorney Jennifer Nichols disappears, the team investigates the last few days in her life and soon find that she had grown disillusioned with her most recent relationship with Allen Davis. Discussions with a married ex-lover reveal that Nichols had recently gone through an old case file relating to a ten-year-old bank robbery, which has a connection to her recent relationship. Jack and Ann avoid discussing a recent development in their relationship -- her pregnancy.

Wendy Kim goes missing during her shift at the family deli, and the team gets involved to find out what happened to the young Korean woman. It isn't long before they learn that Wendy had recently broken off an engagement to a young Korean man her parents were very supportive of, and that she had recently been doing a lot of on-line dating and had gotten herself involved with the wrong kind of men, including one who wouldn't take no for an answer.

The team discovers a long festering secret which sets off a deadly chain of events when they investigate the disappearance of the teenage son of a Secret Service man.

The team searches for a recently blinded girl and her companion who disappeared during a camping trip. Vivian takes over as the supervisor, while Jack struggles to say goodbye to his family.

A young mother disappears after leaving her three year old son with a babysitter.

Max Cassidy vanishes after leaving a message on his wife's voicemail, with both Jack and Ann frantic to find him. While investigating, Jack realises that Max was having an affair, and that he's gotten much deeper into a case than he should have following the murder of his partner, Jimmy, a man Max had felt was too green for undercover work. Both Jack and Ann fear the worst as the team tries to hunt down Max.

Megan Sullivan is H.I.V. positive, pregnant and missing. Initially the team suspects that her husband, who seemed to be less than thrilled about the baby, is involved, but soon learn that Megan had received a call from a prison, and their search tracks them to a former lover, who gave her H.I.V., her husband's former mistress, who had seen her taking part in a tense conversation not long before she vanished, and her own H.I.V. specialist, who had recently given her bad news. Martin thanks Danny for his help, and tells him that he is continuing to seek counseling for his addiction.

Vivian thinks about her recent surgical problems while searching for a missing woman with a terminal condition.

The team tries to determine whether or not the recent disappearance of an air traffic controller has connections to the Middle East. The team soon learns that his wife died in an automobile accident and he was having an affair with her sister.

Barry Rosen goes missing shortly after being poisoned with bleach in a chili eating contest. While investigating Barry's disappearance, the team soon learns that he had been approached to throw the eating contest, and also that he had been spending a lot of time with a local prostitute in an effort to learn how to act around women. Danny is caught in the middle when Carlos asks him for a letter of reference in an upcoming custody review, and Elena informs him that Carlos is actually suing her for sole custody of Sofie. Danny warns Carlos that he is not going to be caught in the middle.

The team find themselves up against the ropes as multiple mysteries arise in the case of a boxer. Dante Jones disappears moments before a bout with a $500,000 purse that which could have made him a title contender. Jack suspects it's stunt, but Vivian, a Jones fan, can't believe that the charity-loving, straight-arrow fighter would go doewn that low road. The search goes in a new direction when his younger brother who he is always bailing out of trouble, vanishes. Then it's learned he has made 2 million dollers in the past five years,but he only has $6000 in his bank account.

The team investigates the disappearance of social worker Eric Hayes, who had given thirty days notice to his job not long before. When their investigation leads them to a young pregnant woman who had already lost one child to the system, the agents begin to believe the disillusioned social worker may have been having an affair but soon discover that he may have been trying to right the wrong that drove him from his job. Danny has trouble with the investigation, as it reminds him of his own experience in foster care. Jack confides in Samantha about his relationship with Ann, but it may be too late.

The team searches for a missing mother who they believe may be searching for her son, who is also missing.

Martin brings the team in on the hunt for a young woman that went missing after a priest attempted to exorcise a demon from her. He begins to feel guilty when he finds out he used to work with her, but doesn't remember her.

The team searches for missing water plant supervisor Jason Turner, and learn that he had become the target of a lot of anger after recent layoffs at the plant. Carlos comes to the office looking for Elena.

When a young, interracial boy goes missing, race and money appear to play the starring roles in the investigation.

The team searches for Chris Manning, a family court judge with a soft side who went missing after meeting with a young boy caught between his mother and his abusive father. Suspicion initially turns anyone Manning may have riled up due to his court rulings, but after his clerk is shot in what appears to be an attempt on Manning's life, the team learns that the secret behind Manning's disappearance is tied up with something that happened over twenty years earlier.

Jack and the team investigate when Sadik Marku's son goes missing along with the boy's mother, and Samantha worries that Jack is more interested in settling an old score with Marku than with finding the missing woman and boy.

The team investigates when Aaron Gibbs ends up missing one night and soon learn that he had been lying to his wife about quitting his job, and had been working nights in a fight club. During the course of the investigation, Jack and the others learn that Aaron's disappearance was connected to events that took place during Hurricane Katrina, when Aaron was fighting to save his sons, and follow the trail of evidence, believing that the events of that night in New Orleans hold the key to finding the truth about the missing man.

When 17-year-old Ted Soros goes missing after a basketball game, the team begins an investigation, soon learning that Ted was an emancipated minor who was living on his own to attend a school with an exemplary basketball program. Learning he had recently contacted his mother with a request for legal advice from an uncle, the team begins to suspect that Ted may have done something that he could face criminal charges for, and realise that Ted's secret is connected to a university recruiting party. While the team works Ted's disappearance, Jack learns from Ann that she lost the baby, and waits for her at the clinic while she seeks medical attention.

When a young artist disappears, the team is concerned that one of her subjects may have been unhappy with her work.

A former soldier, now stuntman, goes missing and the team learns that he changed his will only short time before he went missing which makes them wonder who needed the money.