The team considers if a father who cleans crime scenes for a living led to his disappearance with his daughter.

When a college student disappears after making racial remarks in a class, the team wonders if those may be directly connected to his disappearance.

The team Search for a missing motivational speaker only to find that there is an abundance of suspects,The find out that they man is no who he appears to be.

The four-year-old adopted son of a celebrity couple is kidnapped, and the team must determine if the reason has to deal with the parents' status or the boy's own Sudanese origin.

The team searches for a missing mother who they believe may be searching for her son, who is also missing.

The disappearance of an ultimate fighter leads the team to investigate his background, where they learn the man had a number of enemies.

Maggie Cartwright appears to have simply walked away from every thing in her life, having left everything of hers behind. Later a ransom note appears on her mother's email list demanding a million dollars for her safe return.

Chet Collins has been searching for his son since the boy was kidnapped four years earlier on a camping trip, and is the one case that Jack has never been able to forget. When Chet disappears, leaving behind only his wedding ring and the mountains of debt he had accumulated in his search, Jack will go to any lengths to find Collins and save him from himself.

The team find themselves up against the ropes as multiple mysteries arise in the case of a boxer. Dante Jones disappears moments before a bout with a $500,000 purse that which could have made him a title contender. Jack suspects it's stunt, but Vivian, a Jones fan, can't believe that the charity-loving, straight-arrow fighter would go doewn that low road. The search goes in a new direction when his younger brother who he is always bailing out of trouble, vanishes. Then it's learned he has made 2 million dollers in the past five years,but he only has $6000 in his bank account.

When a woman disappears after her boyfriend is killed by the police, the team suspects gang involvement. Later, Sam learns she's pregnant.

An office shooting forces a woman to disappear, possibly to hide a deep secret.

Malone and his team start off the new year investigating how a private investigator might have went missing.

Jack goes missing after taking a case into his own hands which soon becomes intertwined with a human trafficking prostitution case that Vivian is working on.

Jack and the team search for a pregnant woman, Kathy Dobson, who disappeared from a hospital before being told that she has serious complications. As the detectives race against time to find Kathy, their investigation gradually reveals that Kathy's seemingly happy life actually hasn't been going very well. She is eight-and-a-half months pregnant and, under the tight control of her husband Paul, has withdrawn from her family and friends. Paul's brother Ritchie, who has been following Kathy and providing Paul with addresses she visits, lists a woman who may be affiliated with an ""underground railroad"" that helps battered women. When the team members find the woman, they learn that she has been assaulted by Paul—but she still refuses to lead them to Kathy.

They search for a young high-school teacher who disappeared after a night class in the Bronx, turning up contradictory information about the subject.

A 12 year old boy (Jake Thomas) goes missing. The team discovers that the boy had a rough 24 hours leading up to his disappearance. He disappeared in the middle of the school day, the only clues a broken miror, a discarded hall pass, and blood on the wall....until a picture of him is sent around the school.

The team determines if an ex-con's past criminal activity caused her to disappear after visiting a prison inmate. Det. Mars and Agent Johnson also continue their investigation.

A child prodigy turned store Santa vanishes and the team wonders if he had criminal connections.

After telling his mother, he wanted to leave school for good, seventeen year old Andy Deaver vanishes from his private boarding school, last seen by it's headmaster, Graham Spaulding.

A bride disappears at her own wedding and suspicions of kidnapping. Meanwhile, the team explores the relationship between the newlyweds, who were lived together for a little while.

When the team tries to plot a strategy after they find out that Samantha has been shot and that she might be critically injured in the hostage crisis situation. Jack makes a deal with Berry so that Sam can get help and Jack goes in there and takes Sam's place.

After young Shawn Hopkins disappears one night after leaving the arcade, his parents soon begin to believe that the team is not doing everything to find their daughter, and are shocked to learn that their son has been gambling and has also been seen with a local drug dealer. After learning that Shawn had taken up the cause of a friend who had been raped, Larry and Susan Hopkins are relieved to learn that their son wasn't doing anything wrong, but worried that he still might not come home.

When Luke Horton disappears after a class reunion, the team initiates a search for him, and learn that Luke was living a double life and was finally ready to come clean.

After the latest lottery winner goes missing, the team works to figure out why.

A school bus is abducted by kidnappers who demand more and more for ransom.