Jesse is arrested and charged with murder after a doctor testifying against Jesse in a malpractice suit is poisoned. Mark convinces his old friend, Ben Matlock, to defend Jesse.

Mark, Steve, Jesse, and Amanda are all trapped in the rubble of Community General in the aftermath of the bombing. Mark tries to shake off the numbing effects of the explosion in time to save Amanda, who's suffering from a punctured lung and broken collarbone. After the dust settles, the hunt for Caitlin Sweeney begins. It's discovered that the Sweeneys belong to a terrorist organization, R.O.A.R.

Steve becomes embroiled in political intrigue after the murder of a city councilman's wife appears to be part of a larger political strategy. Steve investigates two mayoral candidates, the councilman and the chief of police, as well as a rogue detective and his partner, all with strong motives.

Dr. Sloan tries to save Jesse and Amanda from a murderer who is out to kill them in order to obtain a multi-million dollar inheritance.

A priest kills his would-be blackmailers and does everything he can to cover his tracks. Dr. Sloan investigates when details don't quite add up.

Security is increased at the hospital when Senator Robert Bassett undergoes an operation. Drs. Sloan and Stewart are preoccupied when a beautiful young amnesia patient is brought in. Unbeknownst to them, their beautiful young patient is a professional killer.

When an abrasive, washed-up comic is found dead at a Community General benefit telethon, suspicion is cast on everyone from his son to his former writers.

Mark's cousin, Jonathan Nash, bequeaths his million-dollar fortune to Community General Hospital. His three dastardly children are the main suspects after Nash dies suspiciously... before he has a chance to alter his will.

After a dying man gives Dr. Sloane a winning lottery ticket, the deceased's family and creditors swarm him, claiming the ticket is theirs.

A group of crooked cops frame Steve for murder after he gets too close to their robbery operation. Jack visits some past friends, now mobsters, to dig up information.

The same gang involved in the Schroeder murder kidnaps Mark's underworld friend, Gus Benedict. Jack and Mark try to save Benedict before time runs out.

Dr. Sloan treats a famous singer,then takes her into his home as a homicidal closes in.

Financier Robin westlin dies in Dr. Sloan's house, but when the paramedics at the scene, the body's gone. Everyone is certain the event was a figment of Mark's imagination. Dr. Sloan goes on a quest to validate his theory.

A team of Magicians Clark & Madison, breaks up when Paul Madison decides to go solo. Mark jumps to his friend Clark's aid when Madison turns up dead with Eddie Clark the main suspect.

Steve's latest girlfriend, a dance instructor, is a suspect in a murder investigation when a dance club's owner dies mysteriously.

A tell-all book written by one of Amanda's vindictive old college roommates contains embarrassing secrets of all four roommates. Dr. Sloan tries to discover what happened when the author is found dead and Amanda is the main suspect.

A prostitute, who tells Jack of her plans to blackmail her clients, is found dead of an apparent drug overdose. Dr. Sloan interviews her clients to discover the real cause of death.

An unhappy politician's wife guns down her husband in an underground garage. Mark sees through her alibi and attempts to confirm his suspicions.

Chet Brooks, one of Jack's old friends, shows up on the run from gamblers, begging for help. Jack reluctantly loans Chet his car, only to have Chet and the car explode in a fiery wreck. Jack tangles with the underworld to find out what happened.

A convict, being treated at County General, manages to take a hostage and demand news coverage. When the newscaster covering the event is shot down, Dr. Sloan takes it upon himself to figure out what went wrong.

A Los Angeles earthquake apparently causes an armoire to topple over on top of a good friend of Dr. Sloan's, Martin Garfield, killing him. The dry-eyed Sloan goes to work and discovers that Garfield may have been killed before the earthquake. Jack and Amanda help Mark weed through the wealthy family to find the murderer.

A gangland 'protector' under surveillance by Steve becomes infected with the plague when a medicine bottle is mysteriously switched. Dr. Sloan tries to find the source of the virus before the murderer starts an epidemic.

Dr. Sloan goes undercover at a convent when mysterious circumstances surround a murder.

Dr. Sloan is under suspicion after his tax preparer is killed with Mark spotted 'hovering' over the body.

Suspicion is cast on Norman Briggs after the chairman of a philanthropical medical group of which Norman is a part, is murdered. Steve and Mark attend the funeral to nail the culprit, who promptly falls over dead.