Mark, Steve, Jesse, and Amanda are all trapped in the rubble of Community General in the aftermath of the bombing. Mark tries to shake off the numbing effects of the explosion in time to save Amanda, who's suffering from a punctured lung and broken collarbone. After the dust settles, the hunt for Caitlin Sweeney begins. It's discovered that the Sweeneys belong to a terrorist organization, R.O.A.R.

Dr. Sloan and Amanda investigate when the co-pilot of the airplance carrying them to a medical conference is murdered and the remainder of the flight crew are incapacitated with a mysterious illness.

A young woman is assassinated while Dr. Mark Sloan is examining her, setting off an investigation that plunges Mark into dark memories of his own childhood.

Two women involved in a love triangle plot to murder a man, take his millions, and leave the country. Dr. Sloan investigates after his friend's mysterious disappearence.

A burglar inadvertently becomes infected with a deadly virus. Dr. Sloan and Jesse are subsequently exposed to the virus after Jesse stumbles upon the thief's dead body. Both Mark and Jesse are confined to Mark's home while Steve and Amanda investigate the drug company that manufactured the virus, in the hopes of discovering an antidote before Jesse runs out of time.

Mark aids an old friend, Joe Mannix, in solving a 25-year-old, unsolved murder.

Dr. Sloan investigates when an unpopular colleague drops dead while performing an operation. Mark investigates his fellow doctors when tests reveal the deceased was poisoned.

A wealthy woman and her boyfriend dupe Mark and plot to murder her husband.

Steve nearly dies in a car accident and think a murder happens. No one believes him.

Mark must find out why his dad left him as a child.

Dr. Sloan tries to save Jesse and Amanda from a murderer who is out to kill them in order to obtain a multi-million dollar inheritance.

One police officer is accidentally shot by another during a raid gone wrong. Dr. Sloan investigates the victim's wife, the shooter, and a conniving lawyer when he suspects foul play.

Mark investigates a 30-year old murder when the body of his old mentor is discovered entombed in a wall in the hospital.

A devious psychologist uses hypnotism to facilitate his criminal acts, including the murder of his wife.

Dr. Sloan is stalked by a mad bomber whom he helped incarcerate. Norman and Mark are the main dissenters in negotiations to sell the hospital to a corporate raider.

Steve becomes embroiled in political intrigue after the murder of a city councilman's wife appears to be part of a larger political strategy. Steve investigates two mayoral candidates, the councilman and the chief of police, as well as a rogue detective and his partner, all with strong motives.

Community General is already under increased security, with a high-profile criminal hospitalized, when an important businesswoman is brought in. Mark suspects her security guard has deadly intentions.

A spat between a girl and her boyfriend leads to an apparent murder, leaving the girl and her mother with a dead body, just as dinner guests Mark and Amanda arrive. Panic sets in, when the body disappears, the power goes out, the roads are impassable, and the attacks begin.

An abusive man who, along with four other people, was a contestant on a reality show is murdered while living in a house that is monitored 24 hours a day. After the killing, Mark enters the house as the man's replacement to see if he can uncover what happened.

At Jack's request, Mark operates on a Godfather-like mobster, Albert Bartell... and faces retribution from the man's son when Albert dies suddenly.

The body of a dead real estate agent is found in the walk-in closet of Mark's sister's new house. Mark and Steve have to work around Dora Sloan's annoying habits while investigating the murder.

A respected cardiologist murders an innocent man in an insurance scam. Dr. Sloan reluctantly investigates his friend.

Mark's daughter returns after eight years, leaving an abusive husband who later turns up dead.

Dr. Sloan investigates a plastic surgeon when an actress's death apparently results from an infection contracted during surgery.

The Sloans run into plenty of industry politics when they investigate the death of television network executive, Rachel Woodrall. Seamy revelations about Woodrall's college sorority lead to the killer.