Jesse is arrested and charged with murder after a doctor testifying against Jesse in a malpractice suit is poisoned. Mark convinces his old friend, Ben Matlock, to defend Jesse.

Newly retired detective Harry Trumble returns to the force when it appears 'The Clown Killer', a murderer Trumble chased for more than a decade, has emerged from obscurity to kill again. Mark is reluctant to help Harry investigate the Clown, in part due to a rift between the two, but also because Mark suspects Harry has something to do with the Clown's reappearance.

Hospital horticulturist Claude is revealed to be an escaped convict living under an assumed name for the past 10 years. Mark fights to shelter Claude from extradition while striving to prove his innocence.

A young woman is assassinated while Dr. Mark Sloan is examining her, setting off an investigation that plunges Mark into dark memories of his own childhood.

Steve goes undercover as a doctor in a private community after several mysterious deaths occur within its confines. Steve is 'aided' by a tabloid reporter posing as his wife.

Steve nearly dies in a car accident and think a murder happens. No one believes him.

An abusive man who, along with four other people, was a contestant on a reality show is murdered while living in a house that is monitored 24 hours a day. After the killing, Mark enters the house as the man's replacement to see if he can uncover what happened.

Mark must find out why his dad left him as a child.

Dr. Sloan tries to save Jesse and Amanda from a murderer who is out to kill them in order to obtain a multi-million dollar inheritance.

Two women involved in a love triangle plot to murder a man, take his millions, and leave the country. Dr. Sloan investigates after his friend's mysterious disappearence.

Steve becomes embroiled in political intrigue after the murder of a city councilman's wife appears to be part of a larger political strategy. Steve investigates two mayoral candidates, the councilman and the chief of police, as well as a rogue detective and his partner, all with strong motives.

Community General is already under increased security, with a high-profile criminal hospitalized, when an important businesswoman is brought in. Mark suspects her security guard has deadly intentions.

A spat between a girl and her boyfriend leads to an apparent murder, leaving the girl and her mother with a dead body, just as dinner guests Mark and Amanda arrive. Panic sets in, when the body disappears, the power goes out, the roads are impassable, and the attacks begin.

Steve teams with a Naval Investigator when the apparent suicide of a military officer turns into a cold-blooded murder.

The body of a dead real estate agent is found in the walk-in closet of Mark's sister's new house. Mark and Steve have to work around Dora Sloan's annoying habits while investigating the murder.

The Sloans run into plenty of industry politics when they investigate the death of television network executive, Rachel Woodrall. Seamy revelations about Woodrall's college sorority lead to the killer.

Mark, Jesse, and Amanda are trapped in a hotel when it's quarantined after a deadly virus is released. They struggle to contain the virus, while at the same time trying to locate its origin. Meanwhile, a scheming seductress carries out her plan, using the virus as a diversion to rob a nearby bank vault.

A med student, surrogate daughter to Madison Wesley, is sent to a rehab program to kick drugs. Once there, she's wrongly accused of murdering a fellow patient. Mark sets his sights on bringing down the real culprit.

Mark's old friend, singer Danielle Marsh, visits and begins exhibiting erratic behavior while dodging attempts on her life. Mark attempts to fight through Marsh's defensive barriers to help his friend.

An actress with an eating disorder dies from an apparent heart attack. Mark believes her nutritionist murdered her.

A cantankerous patient at Community General is given a double injection of his medication, eventually leading to his death. Jack suspects a doctor he's had a grudge against for a long time. Despite Mark's objections, Jack sets out to prove his ""enemy"" is the killer.

At Jack's request, Mark operates on a Godfather-like mobster, Albert Bartell... and faces retribution from the man's son when Albert dies suddenly.

A plastic surgeon dies due to an overdose of laughing gas... with no shortage of suspects. Mark campaigns furiously to exonerate Bonnie Valin, the victim's wife, while Steve makes a solid case against her. Meanwhile, Amanda's new electronic checking service is less than effective.

One of Steve's old ""collars"" gets out of prison and comes looking for revenge.

Mark investigates when a teenage girl is murdered after threatening to reveal her affair with her older lover, a newly appointed state Supreme Court Justice.