Again with his white coat, Doc faces his first day as head physician. He has new responsibilities to manage without neglecting patients, despite pressure from the Administrative Director who threatens to close the department. Fortunately, Doc can count on his team, although Julia has not set aside the idea of leaving and Richard is challenged by the new residents.

Doc continues to dig into his memory and, now that he has finally met his "sail," he has a clear lead to follow. He has Giulia at his side who, in addition to Andrea's problems, must also think about her career. Meanwhile, a famous travel blogger is admitted to the ward and entrusted to Federico's care. But this encounter is likely to create more than a few problems.

The search for Doc's memory seems to have come to a dead end, but Andrea has found a new "sail": the upcoming choir competition in honor of Mattia. While he tries to convince Agnese to accompany him, in the ward Federico ends up under pressure, and Riccardo is faced with a case that sends him into crisis and pushes his relationship with Martina to the limit.

Doc finally knows how to track down the woman he is looking for, but he must first find the courage to do so. Meanwhile, Ric faces the case of an undisciplined personal trainer, while Damiano must deal with the hospitalization of a model, his brother Samuele's girlfriend. This case threatens to bring up old family grudges.

The fear of discovering the secret about his past is too strong for Doc. However, this denial of the truth drives him away from the ward, much to the surprise of Giulia, who has to take care of a patient who, just like Andrea, seems to be hiding something. Meanwhile, Enrico must deal with Barbara's assaults, which may be hiding more than just infatuation.

A violent earthquake sows panic at the Ambrosiano Hospital. Lin is afraid for her family; Ric decides on Laura's proposal; Federico has to perform a surgery for which he does not feel ready; Martina has an encounter that threatens to bring up her secret; Giulia, on the other hand, has to manage the ward because Doc is stuck in an elevator and has to save a pregnant patient.

The deadline to submit the research is approaching, but Giulia seems to have other things on her mind. Even Doc struggles to manage the myriad commitments: there's the meeting with the funders and then there's Carolina, who is in town for a few days. Everything takes a back seat, however, when Lin's sister is hospitalized. A case that will force the resident to come to terms with her father.

Giulia must make a decision about her personal life that will also affect her career. While Martina faces the most difficult exam of her life, Ric takes on a case that will force him to come to terms with Alba's ghost. Lin and Federico, on the other hand, get back to work on the database, but they risk bringing Doc closer to the truth that Agnese has been hiding from him.

Andrea is forced to come to terms with Agnese's illness, but unexpected news from America reawaken his hopes. At the hospital, however, the new head physician is challenged by a case that will force someone to make a terrible compromise. Meanwhile, Lorenzo is entrusted with a patient who has arrived from a nursing home and has been prescribed an overdose of medication.

In the ward, the moment of truth has arrived. As Federico faces his last day at Ambrosiano Hospital and Martina makes a decision that leaves the rest of the team stunned, Doc must come to terms with the truth Agnese has told him. He is convinced that it can't get any worse - until the man responsible for it all, his worst enemy, is admitted.

It's the day of the primary simulation for Doc: Andrea for a day returns to wear the gown, but a sudden computer blackout of the hospital's systems forces him to a series of risky choices.

Agnese's condition rapidly deteriorates and Andrea receives the support of the whole ward in the attempt to discover what disease she is suffering from. However, the accusations levelled against him regarding his involvement in the falsification of data on pharmaceutical trials risk him having to leave the hospital for good.

A special episode set ten years earlier. Andrea, an enthusiastic doctor who is still together with his family, has an opportunity to make a career jump for the first time. But it is a struggle to hold everything together: suddenly finding himself involved in a rivalry with his colleague Marco, he risks losing sight of who he really is.

Professor Andrea Fanti, a brilliant Head of Internal Medicine, has his life turned upside down when the father of a patient who has died in his ward shoots him in the head. Andrea survives the shooting, but loses his memory of the last twelve years of his life. When he wakes up, he struggles to recognize his colleagues, his family and the man he had become.

Andrea is hospitalized in the Internal Medicine ward, in the hope that over time the place most familiar to him will help him recover his memory. Giulia oversees his rehabilitation, but finds herself dealing with a different man to the one she knew.

A patient sheds light on a secret about Lorenzo's private life that causes a stir throughout the ward. Meanwhile, Gabriel and Elisa must attempt to reconstruct the life of an elderly inpatient who appears not to remember anything about himself, but repeatedly utters a single word.

Locked in the ward in a forced quarantine, doctors are engaged in a fight against time to stop a multidrug-resistant bacterium that has infected them all.

Andrea finds himself in hot water when a former trainee accuses him of falsifying data from a pharmaceutical trial: unable to defend himself due to his amnesia, he seeks confirmation from people close to him. In the meantime, Lorenzo has to fight to get Chiara on the transplant list and Agnese has a sudden illness.

Andrea returns to the ward as an assistant to the trainees, who were terrified of him just a few weeks earlier and find it hard to get used to the unexpected role reversal. While he tries to win back his ex-wife, his collaboration with Giulia on the case of a young manager proves to be challenging and full of surprises.

The arrival of a patient who is particularly important to Giulia intensifies the competition between the interns and Andrea has an opportunity to really get to know them. Meanwhile, he involves the ward in the search for his email account password, which could help him reconstruct a key part of his past, but which someone wants to hide from him at all costs.

Carolina, who is suffering from a mysterious illness, is admitted to the ward, triggering a series of conflicts between Andrea and Agnese that they will have to overcome for their daughter's sake. Meanwhile, a flashy influencer attracts the young trainees' attention and Alba cannot disguise her jealousy towards Riccardo.

In an attempt to return to his role as a father and to help Carolina recover from her illness, Andrea starts to pursue Agnese again. A bad headache creates problems for Gabriel while treating a patient. Elisa and Riccardo have to deal with an aspiring astronaut.

After finding the medical file on the patient who died because of a mistake, Andrea tries to reconstruct what happened before the shooting that wiped out his memory. Marco, who was responsible for this death, and Agnese are uncooperative. Alba and Riccardo struggle to rebuild their relationship and things also get complicated between Gabriel and Elisa.

A train accident turns the Internal Medicine ward into an improvised emergency room. All the doctors are required to do their best to deal with the emergency. One of the wounded is a girl who reopens an important chapter in Riccardo's past that the young man had considered closed forever.

Lorenzo has issues again with his ex-girlfriend Chiara, who is then hospitalized after overdosing. Marco and his wife feel increasingly threatened by the research that Andrea is carrying out on Satonal, the experimental drug that appears to have caused several deaths. Meanwhile, Gabriel has to explain to his community that he intends to settle in Italy.