Professor Andrea Fanti, a brilliant Head of Internal Medicine, has his life turned upside down when the father of a patient who has died in his ward shoots him in the head. Andrea survives the shooting, but loses his memory of the last twelve years of his life. When he wakes up, he struggles to recognize his colleagues, his family and the man he had become.

Andrea is hospitalized in the Internal Medicine ward, in the hope that over time the place most familiar to him will help him recover his memory. Giulia oversees his rehabilitation, but finds herself dealing with a different man to the one she knew.

Andrea returns to the ward as an assistant to the trainees, who were terrified of him just a few weeks earlier and find it hard to get used to the unexpected role reversal. While he tries to win back his ex-wife, his collaboration with Giulia on the case of a young manager proves to be challenging and full of surprises.

Engaged in following two cases at the same time to prove that he is up to the primary, Doc is in direct competition with the new primary and takes several risks.

Agnese is surprised to find Manuel's mother hospitalized, the child she has in foster care with Davide, and with whom things do not seem to go too well. Agnese will have to question everything she thinks she knows, just when Andrea seems to want to be closer to her than ever.

Dealing with the case of a young tennis phenomenon, Andrea is forced to wonder if it is worth stopping being "Doc" to pursue the primary.

In this special episode, while the investigation conducted by Caruso comes to life and the secrets of the pandemic begin to emerge, Andrea faces a difficult choice: to get back the primary he must take tests, but if he fails, he will never be able to be a doctor again.

While Caruso's tests have the increasingly clear intent to put Doc in difficulty, Cecilia also begins to discover the secret of the team.

Andrea is forced to come to terms with Agnese's illness, but unexpected news from America reawaken his hopes. At the hospital, however, the new head physician is challenged by a case that will force someone to make a terrible compromise. Meanwhile, Lorenzo is entrusted with a patient who has arrived from a nursing home and has been prescribed an overdose of medication.

While a small war breaks out between Doc and the surgeon Valenti because of Carolina, Doc must face the case of a boy with very present parents and is forced to question himself as a father.

February 2020. Doc is determined to keep his team together that is falling apart: Giulia will move to Genoa, Lorenzo will perhaps leave medicine, Gabriel is leaving for Ethiopia and even Elisa no longer seems interested in the department.

While Andrea seems intent on leaving everything, refusing to deal with the difficult case of the nurse Giacomo, a new internist, Damiano Cesconi, and a new infectious disease specialist, Cecilia Tedeschi, arrives in the hospital, but above all a new primary, who seems ready to dismantle the department from the inside.

While our doctors are forced to take care of a patient, the rift between Doc and Carolina widens more and more, and Andrea must deal with himself.

While the doctors are busy solving the delicate case of a deafblind boy, Cecilia makes Doc an unexpected offer, triggering the jealousy of Agnese and Giulia.

The therapy sessions with Enrico seem to have side effects on Doc, who sees his ability to take care of patients called into question. Agnese seizes the opportunity to crush his research into the past, while Giulia is convinced that Andrea should not give up, despite his problems: in fact, his brother Fabio is admitted to the ward.

The arrival of a patient who is particularly important to Giulia intensifies the competition between the interns and Andrea has an opportunity to really get to know them. Meanwhile, he involves the ward in the search for his email account password, which could help him reconstruct a key part of his past, but which someone wants to hide from him at all costs.

Giulia brings Andrea back to the ward for a patient who has asked to be exclusively examined by him and who does not know about his current condition. An error caused by his amnesia puts all the trainees under pressure. Meanwhile, Alba is forced to confront the resentment she feels towards her mother.

A special episode set ten years earlier. Andrea, an enthusiastic doctor who is still together with his family, has an opportunity to make a career jump for the first time. But it is a struggle to hold everything together: suddenly finding himself involved in a rivalry with his colleague Marco, he risks losing sight of who he really is.

Carolina, who is suffering from a mysterious illness, is admitted to the ward, triggering a series of conflicts between Andrea and Agnese that they will have to overcome for their daughter's sake. Meanwhile, a flashy influencer attracts the young trainees' attention and Alba cannot disguise her jealousy towards Riccardo.

In an attempt to return to his role as a father and to help Carolina recover from her illness, Andrea starts to pursue Agnese again. A bad headache creates problems for Gabriel while treating a patient. Elisa and Riccardo have to deal with an aspiring astronaut.

Andrea is confident that he has finally won over Agnese and, feeling romantic, he suggests that a wedding is organised in the ward for a patient in critical condition. Meanwhile, Gabriel makes an unexpected proposal that upsets the balance within the group of interns.

A patient sheds light on a secret about Lorenzo's private life that causes a stir throughout the ward. Meanwhile, Gabriel and Elisa must attempt to reconstruct the life of an elderly inpatient who appears not to remember anything about himself, but repeatedly utters a single word.

After finding the medical file on the patient who died because of a mistake, Andrea tries to reconstruct what happened before the shooting that wiped out his memory. Marco, who was responsible for this death, and Agnese are uncooperative. Alba and Riccardo struggle to rebuild their relationship and things also get complicated between Gabriel and Elisa.

A train accident turns the Internal Medicine ward into an improvised emergency room. All the doctors are required to do their best to deal with the emergency. One of the wounded is a girl who reopens an important chapter in Riccardo's past that the young man had considered closed forever.

The arrival of Elisa's older sister in the hospital, a likeable, charming actress, inexplicably makes the young trainee even more surly and bad-tempered. Andrea continues to delve into the years that amnesia has wiped out, while Agnese cannot mask her jealousy over the growing rapport between Giulia and Andrea.