Roger returns with his gigantic nose growths in the hopes that Dr. Lee and her colleagues can help before it's too late. Christine has lost her essence due to a large growth on her shoulder. Tiffany has a recurring cyst on her eyelid.

Yaellie, a sweet 9-year-old, has itchy psoriasis on over 90 percent of her body. Matt, a former Marine, has a large recurring lump in his armpit. Twins Tracie and Stacie have numerous matching bumps on their heads that sometimes leak.

James has a large, squishy lump on his forehead; Tanisha has a growth on her arm and itchy scars all over her body; Ed wants his stomach lump removed before his girlfriend gets out of prison; Justin has painful mystery bumps all over his head.

JD is a gentle giant with a pear-shaped mass hanging off of his ear; David has two bumps on his neck and one on his finger that give him pain; Julie hopes Dr. Lee can remove her large back growth so she can return to the sea.

Stephen's large, bulbous nose gets him unwanted attention, and he hopes Dr. Lee can help; Veronica wants to be free of secrets, including the bump on her butt; Marty has a large, 30-year-old growth on his shoulder that he is ready to remove himself.

Roger has enormous growths on his nose that drip pus, attract flies, and are so large that he can barely breathe; Sandra and Jessie are sisters who bonded over their many undiagnosed face bumps.

April is covered in bumps that have disfigured her arms; Genner has flown all the way from the Philippines to have Dr. Lee help with his bumpy nose; Chris suffers from psoriasis that nearly covers his body and a bump on his head.

Jen has substantial growths on her ears that cause her depression, pain, and vertigo. Juliet is under emotional distress because of the bumps all over her neck and chest. Gerald has a mysterious, kiwi-size lump on his middle finger.

John fears the large lump on his neck could become so big that it may eventually suffocate him. Shoshana is depressed because of the big growth on her forehead. Ashley hopes Dr. Lee can provide some relief from her three painful skin conditions.

Ronen's mysterious lump above his knee is one of the largest Dr. Lee has ever seen; Amber suffers from a debilitating skin disease that no one understands; Sandy has a neck lump she calls Tommy; Kristy's eyelid cyst is ruining her life.

Josh has a large knot on his head resulting from a car crash from 18 years ago; Brittney is covered in mysterious bumps; TJ has a hard, curious lump protruding from his side; Luis has a bump on his shoulder and his daughters fear it's dangerous.

Leonard has an alarming bump hanging off of his arm that looks like it's breaking through the skin; Brandon has several lumps on his head that make him fearful for his life; Jess gets a noticeable lump on her butt after falling down the stairs.

Traci's confidence has been destroyed after years of bullying from the bumps on her face; Ravon has a unique dangling growth on his leg; David has a large lump.

Gerard is lumpy, he has nearly a hundred lumps varying in size that coat his entire body. Gina has bloody lesions all over and nobody has been able to help her. Eric has a large bump on his head that he calls his "on/off button."

With pandemic safety protocols in place, Dr. Lee reopens her office. Monica has a large birthmark growing on the side of her face. Jackie has a melon-sized lump on the back of her shoulder. Reginald has large, rare growths on the back of his head.

Joanne has been held back from success because of her forehead growth; Shakisaha split her left earlobe after stretching it with gauges; Mike is a tough guy with a soft bump on his head; Dania's rhinophyma has kept her from enjoying her life.

Half of Mary's body is a size 18 while the other is an 8; Anthony's cyst is in the area called the Triangle of Death; Shane wants to get a lump off his back; Brandi's anxiety may keep her from getting a lump removed from her chest.

Diane has thousands of tumors all over her body that have ruined her life. Will fears his shoulder lump will be ripped open at work. Anthony's daughters force him to get his lump examined; and Kal Elle detests her hideous varicose veins.

Taylore is a beautiful young woman who has unsightly elf-like bumps on her ears; Jose never goes out because of the baseball-sized lump on his head; Ken is covered in painful bumps that make it difficult to do everyday things.

Gerald is back to see Dr. Lee and a hand specialist about a huge, intrusive bump on his middle finger; Vinnie has a large, embarrassing birthmark on his neck; Leta has a lump on the back of her thigh that she has been hiding from her fiancée.

Dr. Sandra Lee treats Heather, who has a huge growth on her leg and fears removing it could leave a keloid scar; Paul has a giant hump on his back.

Dr. Lee tries to provide the help Reginald needs in order to remove two large rare growths on the back of his head; Che'Re has a prominent bump on her face that has put her in a dark place; and Juan has several painful boils on the back of his neck.

Dennis has several giant growths on the back of his head. Juan has a rare condition he hopes Dr. Lee will understand. Natalie searches for answers as to why her body is covered in hundreds of mysterious dark bumps.

Melissa has tried to cover a huge lipoma with a sweatshirt for years; Tyler's fear of cancer has kept him from having his huge head lumps diagnosed; Tahj is covered in painful boils; Amber has ear keloids that have taken control of her life.

Taylor has a large bump at the base of her spine that is far more dangerous than she realizes. John jokes about hip lump, but turns out it's no laughing matter. Noelle had her ears stretched as a teenager, but now wants them repaired.