Lisa has a horn growing out of the back of her head and fears that it could be cancer; Victor has a bulbous lump on his chest; Chuck has a Popeye-shaped bump on his arm; Christian and Jonathan are teenage brothers with matching lumps.

Gabriel has a huge growth on his clavicle but is terrified of surgery. Karen has dealt with painful, scaly feet for 22 years with no diagnosis. Lorne has embarrassing tumors on his face and body and believes this is why he hasn't met "the one" yet.

Ruben is a personal trainer whose head growth has prevented him from seeing clients. Kaitlin has blue marks and scars up and down her arms due to long-term drug use. Adrian was left with a disfiguring bump on her behind after falling down stairs.

Margarita is a matriarch who has been hiding her armpit lump from her family; Kayla is an aspiring musician with a promising career that her painful eczema has brought to a halt; Bradley has a concerning growth that looks like raw meat on his leg.

Tameru is a drag queen, but he has a myriad of cysts that are the real drag. Devon has uneven skin she thinks may be the result of a hysterectomy a decade ago. Amy has large growths all over her head that make her look like a hot mess.

Robert has a small keloid on his ear and a large, snakelike keloid on the back of his head that has been removed and returned three times. Angela has four growths on her head and hides away from those she loves out of embarrassment.

Robert is back to see if Dr. Lee and Dr. Umar can remove his recurring head keloid for good. Justice has small lesions all over her body that get inflamed. Mike has hundreds of lipomas that bring him great discomfort.

Roger has enormous growths on his nose that drip pus, attract flies, and are so large that he can barely breathe; Sandra and Jessie are sisters who bonded over their many undiagnosed face bumps.

Jeremy is a pastor with a hanging growth in an embarrassing location. Evelyn has recurring keloids that have been removed three times and come back bigger each time. Todd has a bump protruding from his forehead that is painful and humiliating.

Roger has a considerable growth on his shoulder that he calls his "second head." Jenna is a bubbly teenager with an even bigger bubble behind her ear. Susan is covered head to toe in bumps that get in the way of her everyday life.

Debra has a large, brainlike growth on the side of her head that feels like a sponge, has crevices and emits an odor. Dusten is a cowboy looking to remove the painful lump on his knee. Ramiro has a bump on his jaw that has already been removed once.

Jason has lost confidence and motivation due to the large growth on his neck. Shawnell has multiple mystery bumps on her head that have destroyed her self-esteem. Jim has a growth protruding off of his nose, making it hard to breathe.

Melissa has tried to cover a huge lipoma with a sweatshirt for years; Tyler's fear of cancer has kept him from having his huge head lumps diagnosed; Tahj is covered in painful boils; Amber has ear keloids that have taken control of her life.

Ronen's mysterious lump above his knee is one of the largest Dr. Lee has ever seen; Amber suffers from a debilitating skin disease that no one understands; Sandy has a neck lump she calls Tommy; Kristy's eyelid cyst is ruining her life.

Half of Mary's body is a size 18 while the other is an 8; Anthony's cyst is in the area called the Triangle of Death; Shane wants to get a lump off his back; Brandi's anxiety may keep her from getting a lump removed from her chest.

Diane has thousands of tumors all over her body that have ruined her life. Will fears his shoulder lump will be ripped open at work. Anthony's daughters force him to get his lump examined; and Kal Elle detests her hideous varicose veins.

Belinda's lump on her neck causes her to basically be immobile; Nicole won't get married until she gets her arm pit lump removed; Adela's chest and back are covered in wisdom spots; Nick foolishly removed a lipoma at home and now needs Dr. Lee's help.

Taylor has a large bump at the base of her spine that is far more dangerous than she realizes. John jokes about hip lump, but turns out it's no laughing matter. Noelle had her ears stretched as a teenager, but now wants them repaired.

April is covered in bumps that have disfigured her arms; Genner has flown all the way from the Philippines to have Dr. Lee help with his bumpy nose; Chris suffers from psoriasis that nearly covers his body and a bump on his head.

Matt has a skin condition that causes tumors to grow all over his body; Yamileth hasn't pursued her dreams because of the lump on her neck; Pat is covered with dark spots from her neck to her abdomen; Jennifer has a unicorn bump on her forehead

Louis is a veteran who is covered in scaly, dry skin that makes him feel like an alligator; Irais's kids are bullied because of the embarrassing growth on her head; Johnny has been living with a stubborn lump on his back for too long.

Amber has hundreds of tumors on her face; Antonio has a mound on his spine and is afraid it might be impossible to remove; sisters Cheri and Janice both suffer from possibly matching lumps; Tatiana has an embarrassing bump on her butt cheek.

Patrick's nose is covered by huge bumps, and he can barely breathe; Aziza and Lauren are friends who bonded over their matching wrist lumps; Joe has a mound in the middle of his forehead that looks like a third eye.

Taylore is a beautiful young woman who has unsightly elf-like bumps on her ears; Jose never goes out because of the baseball-sized lump on his head; Ken is covered in painful bumps that make it difficult to do everyday things.

Barbara's back lump became more noticeable after she lost 131 pounds; Bob has two painful bumps on his back; Hilda's depression is a result of the multitude of bumps on her eyelids; Art has one big bump on his head that he covers up with hats.